公开(公告)号：EP1572960A4

公开(公告)日：2009-03-18

申请号：EP03772003

申请日：2003-07-29

申请人： SENOMYX INC ,  ADLER JON ELLIOT ,  TANG HUIXIAN ,  PRONIN ALEXEY ,  ZOLLER MARK

发明人： ADLER JON ELLIOT ,  TANG HUIXIAN ,  PRONIN ALEXEY ,  ZOLLER MARK

IPC分类号： A61K38/00 ,  C07K14/705 ,  C07H21/04

CPC分类号： C07K14/705 ,  A61K38/00

公开(公告)号：EP1659881A4

公开(公告)日：2013-05-15

申请号：EP04816798

申请日：2004-08-06

申请人： SENOMYX INC

发明人： TACHDJIAN CATHERINE ,  PATRON ANDREW P ,  ADAMSKI-WERNER SARA L ,  BAKIR FARID ,  CHEN QING ,  DARMOHUSODO VINCENT ,  HOBSON STEPHEN TERRENCE ,  LI XIADONG ,  QI MING ,  ROGERS DANIEL HARRY ,  RINNOVA MARKETA ,  SERVANT GUY ,  TANG XIAO-QING ,  ZOLLER MARK ,  WALLACE MARK ,  XING AMY ,  GUBERNATOR KLAUS

IPC分类号： A23L1/226 ,  A61K9/00 ,  A61K47/00 ,  C07C233/65 ,  C07C235/54 ,  C07C275/30 ,  C07C275/34 ,  C07D307/84 ,  C07D317/68 ,  G01N33/566 ,  G01N33/74

CPC分类号： G01N33/543 ,  A23L2/56 ,  A23L27/202 ,  A23L27/203 ,  A23L27/2054 ,  A23L27/88 ,  A23V2002/00 ,  A61K8/4973 ,  A61K8/55 ,  A61K47/22 ,  A61K47/24 ,  C07C233/65 ,  C07C235/54 ,  C07C275/30 ,  C07C275/34 ,  C07D307/84 ,  C07D317/68 ,  C07D405/12 ,  C07F9/65517 ,  G01N33/5041 ,  G01N33/566 ,  G01N33/74 ,  G01N2333/726

摘要： The present invention relates to the discovery that certain non-naturally occurring, non-peptide amide compounds and amide derivatives, such as oxalamides, ureas, and acrylamides, are useful flavor or taste modifiers, such as a flavoring or flavoring agents and flavor or taste enhancer, more particularly, savory (the “umami” taste of monosodium glutamate) or sweet taste modifiers,—savory or sweet flavoring agents and savory or sweet flavor enhancers, for food, beverages, and other comestible or orally administered medicinal products or compositions.

公开(公告)号：EP1934606A4

公开(公告)日：2009-01-21

申请号：EP06816320

申请日：2006-10-04

申请人： SENOMYX INC

发明人： SERVANT GUY ,  BRUST PAUL ,  MOYER BRYAN ,  LU MIN ,  ECHEVERRI FERNANDO ,  DAHAN DAVID ,  ZOLLER MARK ,  WILLIAMS MARK ,  KIMMICH RACHEL ,  KAMDAR POONIT ,  DITSCHUN TANYA ,  PATRON ANDREW

IPC分类号： G01N33/53 ,  C07H21/04 ,  C07K1/00 ,  C07K14/705 ,  C12N15/67

CPC分类号： C07K14/705

摘要： Modified human TRPM8 nucleic acid sequences which are efficiently expressed in human cells and cell-based assays and test kits containing same are provided. These assays identify TRPM8 modulators using cells that express a modified human TRPM8 nucleic acid sequence according to the invention, wherein said sequence has been modified relative to a wild-type human TRPM8 nucleic acid sequence in order to optimize ion channel expression in desired cells. Assays using these modified TRPM8 sequences have been shown to identify compounds that modulate the human TRPM8 ion channel better or comparably to known coolants such as menthol and icilin.