公开(公告)号：EP1976513A4

公开(公告)日：2012-04-18

申请号：EP07716419

申请日：2007-01-05

申请人： SEPRACOR INC

发明人： SHAO LIMING ,  WANG FENGJIANG ,  MALCOLM SCOTT CHRISTOPHER ,  HEWITT MICHAEL CHARLES ,  BUSH LARRY R ,  MA JIANGUO ,  VARNEY MARK A ,  CAMPBELL UNA ,  ENGEL SHARON RAE ,  HARDY LARRY WENDELL ,  KOCH PATRICK ,  CAMPBELL JOHN E

IPC分类号： A61K31/381 ,  A61K31/335

CPC分类号： C07D333/20 ,  C07C211/17 ,  C07C211/29 ,  C07C211/40 ,  C07C215/42 ,  C07C215/44 ,  C07C217/52 ,  C07C217/74 ,  C07C323/32 ,  C07C2601/02 ,  C07C2601/08 ,  C07C2601/10 ,  C07C2601/14 ,  C07C2601/16 ,  C07C2602/08 ,  C07D207/06 ,  C07D207/08 ,  C07D211/14 ,  C07D211/16 ,  C07D265/14 ,  C07D277/28 ,  C07D295/06 ,  C07D307/52 ,  C07D317/58 ,  C07D317/72 ,  C07D319/06 ,  C07D491/056

摘要： The invention relates to novel cyclohexylamine derivatives and their use in the treatment and/or prevention of central nervous system (CNS) disorders, such as depression, anxiety, schizophrenia and sleep disorder as well as methods for their synthesis. The invention also relates to pharmaceutical compositions containing the compounds of the invention, as well as methods of inhibiting reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine from the synaptic cleft and methods of modulating one or more monoamine transporter.

公开(公告)号：EP2154962A4

公开(公告)日：2012-08-15

申请号：EP08756635

申请日：2008-06-02

申请人： SEPRACOR INC

发明人： SHAO LIMING ,  WANG FENGJIANG ,  MALCOLM SCOTT CHRISTOPHER ,  HEWITT MICHAEL CHARLES ,  MA JIANGUO ,  RIBE SETH ,  VARNEY MARK A ,  CAMPBELL UNA ,  ENGEL SHARON RAE ,  HARDY LARRY WENDELL ,  KOCH PATRICK ,  SCHREIBER RUDY ,  SPEAR KERRY L

IPC分类号： C07C215/42 ,  A61P25/24 ,  A61P25/28 ,  C07C217/52

CPC分类号： C07C215/42 ,  A61K31/135 ,  A61P25/24 ,  A61P25/28 ,  C07B2200/07 ,  C07C217/52 ,  C07C217/76 ,  C07C2601/14

摘要： Phenyl-substituted cyclohexylamine derivatives and method for their synthesis and characterization are disclosed. Use of these compounds to treat/prevent neurological disorders as well as methods for their synthesis are set forth herein. Exemplary compounds of the invention inhibit reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine (e.g. from the synaptic cleft) and modulate one or more monoamine transporter. Pharmaceutical formulations incorporating compounds of the invention are also provided.

公开(公告)号：EP1978961A4

公开(公告)日：2010-10-27

申请号：EP06848050

申请日：2006-12-21

申请人： SEPRACOR INC

发明人： SHAO LIMING ,  WANG FENGJIANG ,  MALCOLM SCOTT CHRISTOPHER ,  HEWITT MICHAEL CHARLES ,  BUSH LARRY R ,  VARNEY MARK ,  CAMPBELL UNA ,  ENGEL SHARON RAE ,  HARDY LARRY WENDELL ,  KOCH PATRICK ,  MA JIANGUO

IPC分类号： C07D215/12 ,  A01N43/42 ,  A61K31/47 ,  C07C211/30 ,  C07C211/40 ,  C07C215/44 ,  C07C217/74

CPC分类号： C07C211/40 ,  C07C17/16 ,  C07C17/35 ,  C07C45/38 ,  C07C45/52 ,  C07C45/63 ,  C07C45/67 ,  C07C45/68 ,  C07C45/74 ,  C07C211/29 ,  C07C211/30 ,  C07C211/42 ,  C07C215/44 ,  C07C217/74 ,  C07C2601/14 ,  C07C2602/10 ,  C07D215/12 ,  C07C25/22 ,  C07C22/04 ,  C07C47/453 ,  C07C49/67 ,  C07C49/697 ,  C07C49/255 ,  C07C49/755 ,  C07C49/683