公开(公告)号：EP3239135A4

公开(公告)日：2018-07-11

申请号：EP15871995

申请日：2015-12-28

申请人： SHANGHAI INST MATERIA MEDICA CAS

发明人： SHEN JIANHUA ,  WANG YIPING ,  CHEN XINDE ,  XU WENWEI ,  WANG KAI

IPC分类号： C07D239/52 ,  A61K31/513 ,  A61K31/541 ,  A61P3/10 ,  A61P9/10 ,  A61P27/02 ,  C07D239/48 ,  C07D401/04 ,  C07D403/04 ,  C07D409/04

CPC分类号： C07D239/54 ,  A61K31/513 ,  A61K31/541 ,  C07D239/48 ,  C07D239/52 ,  C07D239/545 ,  C07D239/56 ,  C07D401/04 ,  C07D401/12 ,  C07D403/04 ,  C07D403/06 ,  C07D409/04 ,  C07D413/04

摘要： The present invention relates to pyrimidone compounds used as Lp-PLA 2 inhibitors and pharmaceutical compositions thereof. The structure of the pyrimidone compounds is represented by general formula (I), wherein R 1 , R 2 , R 3 , X, Ar, Y and n are defined as in the specification and claims. The compounds of general formula (I) in the present invention, stereoisomers and pharmaceutically acceptable salts thereof can be used as Lp-PLA 2 inhibitors for preventing, treating and/or ameliorating diseases associated with the activity of Lp-PLA 2 enzyme.