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1.发明授权New seco-D steroids active on the cardiovascular system, processes for their preparation and pharmaceutical compositions containing them 失效在心血管系统的活性开环 - D-类固醇，它们的制备方法和含有它们的药物组合物
公开(公告)号：EP0825177B1
公开(公告)日：2000-04-05
申请号：EP97111643.9
申请日：1997-07-09
发明人： Gobbini, Mauro , De Munari, Sergio , Fedrizzi, Giorgio , Ferrari, Patrizia , Melloni, Piero , Santagostino, Marco , Torri, Marco
IPC分类号： C07C251/58 , C07C281/18 , A61K31/15 , A61K31/155
CPC分类号： C07C281/18 , C07C251/58 , C07C2603/26
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2.发明公开Improved process for the preparation of 3 beta, 14 beta-dihydroxyethialnaldehyde 失效改进的制备3β，14β-二羟基乙二醛的方法
公开(公告)号：EP0684256A2
公开(公告)日：1995-11-29
申请号：EP95830069.1
申请日：1995-03-03
发明人： Gobbini, Mauro , Torri, Marco
CPC分类号： C07J71/0005 , C07J3/00 , C07J3/005 , C07J5/0015 , C07J15/00 , C07J19/00
摘要： A process for producing 3β, 14β-dihydroxyethianaldehyde is disclosed wherein the oxidation of the lactone ring of digitoxigenin-3-acetate is conducted with an alkaline periodate in the presence of a catalytic amount of ruthenium tetroxide obtained in situ by reacting RuO 2 hydrate or RuCl 3 with the alkaline periodate.
摘要翻译： 公开了一种生产3β，14β-二羟基乙醛的方法，其中在碱性高碘酸盐存在下，在催化量的四氧化钌存在下，通过使RuO 2水合物或RuCl 3与原地获得的氧化钌 碱性高碘酸盐。
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3.发明公开Digitoxigenin and dihydrodigitoxigenin 3beta-derivatives and pharmaceutical compositions comprising same for the treatment of cardiovascular disorders 失效洋地黄毒苷和dihydrodigitoxigenin 3-β衍生物及其用于心血管疾病的治疗药物组合物。
公开(公告)号：EP0576913A3
公开(公告)日：1995-04-19
申请号：EP93109610.1
申请日：1993-06-16
发明人： Melloni, Piero , Bernardi, Luigi , Ferrari, Patrizia , Gobbini, Mauro , Torri, Marco , Valentino, Loredana
CPC分类号： C07J19/00 , C07J31/003 , C07J41/0055 , C07J41/0088 , C07J43/003
摘要： Digitoxigenin and dihydrodigitoxigenin 3β-derivatives, a process for their preparation and pharmaceutical compositions containing same for the treatment of cardiovascular disorders such as heart failure and hypertension are disclosed.
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4.发明授权Seco-D steroids active in the cardiovascular system and pharmaceutical compositions containing same 失效在心血管系统的活性开环 - D-类固醇和含有它们的药物组合物
公开(公告)号：EP0742214B1
公开(公告)日：1999-06-16
申请号：EP96830206.7
申请日：1996-04-11
IPC分类号： C07D307/42 , C07D307/46 , C07D307/54 , C07D307/52 , A61K31/58
CPC分类号： C07D307/42 , C07D307/46 , C07D307/52 , C07D307/54
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5.发明授权New cyclopentanperhydrophenanthren-17beta-(hydroxy or alkoxy)-17alpha-(aryl or heterocyclyl)-3beta-derivatives active on the cardiovascular system, processes for their preparation and pharmaceutical compositions containing same 失效新作用于心脏的Zyklopentaperhydrophenanthrene-17-β-（羟基或烷氧基）-17-α-（芳基或杂环基）-3-β衍生物，它们的制备方法和药物制剂的方法及其
公开(公告)号：EP0590489B1
公开(公告)日：1996-12-11
申请号：EP93115247.4
申请日：1993-09-22
发明人： Gobbini, Mauro , Ferrandi, Mara , Frigerio, Marco , Melloni, Piero , Torri, Marco , Valentino, Loredana
CPC分类号： C07J31/003 , C07J1/0011 , C07J17/00 , C07J33/002 , C07J41/0088 , C07J43/003 , C07J51/00
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6.发明公开
公开(公告)号：EP0742214A1
公开(公告)日：1996-11-13
申请号：EP96830206.7
申请日：1996-04-11
IPC分类号： C07D307/42 , C07D307/46 , C07D307/54 , C07D307/52 , A61K31/58
CPC分类号： C07D307/42 , C07D307/46 , C07D307/52 , C07D307/54
摘要： Seco-D steroid derivatives having the formula
wherein R, R 1 , R 2 and R 3 have the meanings specified in the specification, useful as cardiovascular agents and pharmaceutical compositions containing same, are disclosed.摘要翻译： 公开了具有式CHEM的山-D类固醇衍生物，其中R 1，R 2，R 2和R 3具有本说明书中规定的含义，可用作心血管药物和含有它们的药物组合物。
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7.发明公开New cyclopentanperhydrophenanthren-17beta-(hydroxy or alkoxy)-17alpha-(aryl or heterocyclyl)-3beta-derivatives active on the cardiovascular system, processes for their preparation and pharmaceutical compositions containing same 失效在血管系统中活化的新的环戊二烯二氢萘基-17BETA-（羟基或烷氧基）-17ALPHA-（芳基或杂环基）-3BETA衍生物，其制备和其含有药物组合物的方法
公开(公告)号：EP0590489A3
公开(公告)日：1994-06-29
申请号：EP93115247.4
申请日：1993-09-22
发明人： Gobbini, Mauro , Ferrandi, Mara , Frigerio, Marco , Melloni, Piero , Torri, Marco , Valentino, Loredana
CPC分类号： C07J31/003 , C07J1/0011 , C07J17/00 , C07J33/002 , C07J41/0088 , C07J43/003 , C07J51/00
摘要： Cyclopentanperhydrophenanthren-17-(hydroxy or alkoxy)-17-(aryl or heterocyclyl)-3β-derivatives of general formula (I):
wherein:
the symbol means that the hydrogen in position 5 can have an a or configuration; the symbol represents either a single or a double bond;
and X, R, R 1 and R 2 have the meanings given in the description; a process for producing same and their use for the preparation of a medicament for the treatment of cardiavascular disorders such as heart failure and hypertension is disclosed.-
8.发明授权Digitoxigenin and dihydrodigitoxigenin 3beta-derivatives and pharmaceutical compositions comprising same for the treatment of hypertension. 失效用于治疗高血压的洋地黄毒苷和dihydrodigitoxigenin 3-β衍生物及其药物组合物
公开(公告)号：EP0576913B1
公开(公告)日：1997-09-03
申请号：EP93109610.1
申请日：1993-06-16
发明人： Melloni, Piero , Bernardi, Luigi , Ferrari, Patrizia , Gobbini, Mauro , Torri, Marco , Valentino, Loredana
CPC分类号： C07J19/00 , C07J31/003 , C07J41/0055 , C07J41/0088 , C07J43/003
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9.发明公开Improved process for the preparation of 3 beta, 14 beta-dihydroxyethialnaldehyde 失效3-β，14-β-Dihydroxyethialnaldehyde的制备的改进方法。
公开(公告)号：EP0684256A3
公开(公告)日：1996-07-10
申请号：EP95830069.1
申请日：1995-03-03
发明人： Gobbini, Mauro , Torri, Marco
CPC分类号： C07J71/0005 , C07J3/00 , C07J3/005 , C07J5/0015 , C07J15/00 , C07J19/00
摘要： A process for producing 3β, 14β-dihydroxyethianaldehyde is disclosed wherein the oxidation of the lactone ring of digitoxigenin-3-acetate is conducted with an alkaline periodate in the presence of a catalytic amount of ruthenium tetroxide obtained in situ by reacting RuO 2 hydrate or RuCl 3 with the alkaline periodate.
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10.发明授权Improved process for the preparation of 3 beta, 14 beta-dihydroxyethialnaldehyde 失效改进的制备3β，14β-二羟基乙二醛的方法
公开(公告)号：EP0684256B1
公开(公告)日：1998-05-13
申请号：EP95830069.1
申请日：1995-03-03
发明人： Gobbini, Mauro , Torri, Marco
CPC分类号： C07J71/0005 , C07J3/00 , C07J3/005 , C07J5/0015 , C07J15/00 , C07J19/00
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