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公开(公告)号：EP1296715B2
公开(公告)日：2015-12-23
申请号：EP01960390.1
申请日：2001-06-27
发明人： BOUTRIAU, Dominique , CAPIAU, Carine , DESMONS, Pierre, Michel , LEMOINE, Dominique , POOLMAN, Jan
IPC分类号： A61K39/395 , A61K39/102 , A61K39/116 , A61K39/29 , A61K39/295
CPC分类号： A61K39/102 , A61K2039/545 , A61K2039/6037 , Y02A50/466 , Y02A50/484
摘要： A multi-valent vaccine composition is described comprising a whole-cell pertussis component, tetanus toxoid, diphtheria toxoid, and a low dose of a conjugate of the capsular polysaccharide of H. influenzae b.
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公开(公告)号：EP1163000A2
公开(公告)日：2001-12-19
申请号：EP00912626.9
申请日：2000-03-17
发明人： CAPIAU, Carine , DESCHAMPS, Marguerite , DESMONS, Pierre, Michel , LAFERRIERE, Craig, Antony, Joseph , POOLMAN, Jan , PRIEELS, Jean-Paul
IPC分类号： A61K39/385 , A61K39/39 , A61K39/02 , A61K39/005 , A61K39/116 , A61P31/04
CPC分类号： A61K47/4833 , A61K39/092 , A61K39/095 , A61K39/102 , A61K39/12 , A61K39/155 , A61K47/646 , A61K2039/55505 , A61K2039/55572 , A61K2039/6037 , A61K2039/6068 , A61K2039/6075 , A61K2039/70 , Y02A50/414 , Y02A50/484 , Y10S424/831
摘要： The present invention relates to the field of bacterial polysaccharide antigen vaccines. Streptococcus pneumoniae, and optionally a Th1-inducing adjuvant.
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3.发明公开
公开(公告)号：EP1254234A1
公开(公告)日：2002-11-06
申请号：EP01913816.3
申请日：2001-02-13
IPC分类号： C12N15/31 , C07K14/285 , A61K39/102
CPC分类号： C07K14/285 , A61K39/00
摘要： This invention relates to recombinant bacterial outer membrane proteins comprising one or more LB1(f) peptides from surface-exposed loop 3 of MOMP P5 of non-typeable H. influenzae. Polynucleotides encoding these recombinant proteins are also covered. The invention also relates to a method of isolating the recombinant proteins and a vaccine composition for use in the treatment of Haemophilus influenzae infection.
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公开(公告)号：EP1296715B1
公开(公告)日：2011-11-23
申请号：EP01960390.1
申请日：2001-06-27
发明人： BOUTRIAU, Dominique , CAPIAU, Carine , DESMONS, Pierre, Michel , LEMOINE, Dominique , POOLMAN, Jan
IPC分类号： A61K39/395 , A61K39/102 , A61K39/116 , A61K39/29 , A61K39/295
CPC分类号： A61K39/102 , A61K2039/545 , A61K2039/6037 , Y02A50/466 , Y02A50/484
摘要： A multi-valent vaccine composition is described comprising a whole-cell pertussis component, tetanus toxoid, diphtheria toxoid, and a low dose of a conjugate of the capsular polysaccharide of H. influenzae b.
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5.发明授权HYPERBLEBBING BACTERIAL STRAINS AND USE THEREOF FOR PRODUCTION OF VACCINES 有权“HYPERBLEBBING”细菌菌株及其用于疫苗生产
公开(公告)号：EP1357938B8
公开(公告)日：2009-09-09
申请号：EP02700219.5
申请日：2002-02-08
发明人： BERTHET, Francois-Xavier Jacques , DENOEL, PHilippe , NEYT, Cecile Anne , POOLMAN, Jan , THONNARD, Joelle
IPC分类号： A61K39/095
CPC分类号： C07K14/285 , A61K2039/52 , C07K14/195 , C07K14/22 , C12N1/20 , Y02A50/484
摘要： The present invention relates to the field of, engineered Gram-negative bacterial strains that have outer-membrane vesicle shedding properties, and vaccine compositions comprising these bacteria or vesicles. The present invention provides a hyperblebbing Gram-negative bacterium which has been genetically modified by either or both processes selected from a group consisting of: down- regulation of expression of one or more tol genes; and mutation of one or more gene(s) encoding a protein comprising a peptidoglycan-associated site to attenuate the peptidoglycan-binding activity of the protein(s).
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公开(公告)号：EP1296715A2
公开(公告)日：2003-04-02
申请号：EP01960390.1
申请日：2001-06-27
发明人： BOUTRIAU, Dominique , CAPIAU, Carine , DESMONS, Pierre, Michel , LEMOINE, Dominique , POOLMAN, Jan
IPC分类号： A61K39/395 , A61K39/102 , A61K39/116 , A61K39/29 , A61K39/295
CPC分类号： A61K39/102 , A61K2039/545 , A61K2039/6037 , Y02A50/466 , Y02A50/484
摘要： A multi-valent vaccine composition is described comprising a whole-cell pertussis component, tetanus toxoid, diphtheria toxoid, and a low dose of a conjugate of the capsular polysaccharide of H. influenzae b.
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