公开(公告)号：EP0849361B1

公开(公告)日：2005-08-10

申请号：EP97310216.3

申请日：1997-12-17

申请人： SMITHKLINE BEECHAM CORPORATION ,  SmithKline Beecham plc ,  The Board of Regents, The University of Texas System

发明人： Bergsma, Derk J. ,  Brooks, David P. ,  Gellai, Miklos ,  Yanagisawa, Masashi ,  Wilson, Shelagh, c/o SmithKline Beecham Pharm.

IPC分类号： C12N15/12 ,  C07K14/47 ,  C07K16/28 ,  A61K39/395 ,  A61K38/17

CPC分类号： C07K14/575 ,  A61K38/00 ,  C07K16/26

公开(公告)号：EP0849361A3

公开(公告)日：2000-04-19

申请号：EP97310216.3

申请日：1997-12-17

申请人： SMITHKLINE BEECHAM CORPORATION ,  SMITHKLINE BEECHAM PLC

发明人： Bergsma, Derk J. ,  Brooks, David P. ,  Gellai, Miklos ,  Yanagisawa, Masashi ,  Wilson, Shelagh, c/o SmithKline Beecham Pharm.

IPC分类号： C12N15/12 ,  C07K14/47 ,  C07K16/28 ,  A61K39/395 ,  A61K38/17

CPC分类号： C07K14/575 ,  A61K38/00 ,  C07K16/26

摘要： Polypeptides of HFGAN72 receptor ligands and polynucleotides encoding the polypeptides are provided. Methods of using these polypeptides to diagnose diseases relating to the under- or over-expression of HFGAN72 receptor ligands are also provided. In addition, methods of identifying agonists or antagonists of the interaction of HFGAN72 receptor ligands with the HFGAN72 receptor are provided. Methods of treatment by administering the identified agonists or antagonists to patients in need thereof are further disclosed.

公开(公告)号：EP0849361A2

公开(公告)日：1998-06-24

申请号：EP97310216.3

申请日：1997-12-17

申请人： SMITHKLINE BEECHAM CORPORATION ,  SMITHKLINE BEECHAM PLC

发明人： Bergsma, Derk J. ,  Brooks, David P. ,  Gellai, Miklos ,  Yanagisawa, Masashi ,  Wilson, Shelagh, c/o SmithKline Beecham Pharm

IPC分类号： C12N15/12 ,  C07K14/47 ,  C07K16/28 ,  A61K39/395 ,  A61K38/17

CPC分类号： C07K14/575 ,  A61K38/00 ,  C07K16/26

摘要： Polypeptides of HFGAN72 receptor ligands and polynucleotides encoding the polypeptides are provided. Methods of using these polypeptides to diagnose diseases relating to the under- or over-expression of HFGAN72 receptor ligands are also provided. In addition, methods of identifying agonists or antagonists of the interaction of HFGAN72 receptor ligands with the HFGAN72 receptor are provided. Methods of treatment by administering the identified agonists or antagonists to patients in need thereof are further disclosed.

摘要翻译： 提供HFGAN72受体配体的多肽和编码多肽的多核苷酸。 还提供了使用这些多肽诊断与HFGAN72受体配体的低表达或过度表达有关的疾病的方法。 另外，提供了识别HFGAN72受体配体与HFGAN72受体相互作用的激动剂或拮抗剂的方法。 进一步公开了通过将所鉴定的激动剂或拮抗剂给予需要的患者的治疗方法。