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11 条记录 (耗时 0.018 秒)

    G-protein coupled receptor (HFGAN72X)
    4.
    发明公开
    G-protein coupled receptor (HFGAN72X) 失效
    G蛋白偶联受体（HFGAN72X）

    公开(公告)号：EP1154019A3

    公开(公告)日：2003-05-28

    申请号：EP01203008.6

    申请日：1997-10-27

    申请人： SmithKline Beecham Corporation

    发明人： Bergsma, Derk J. ,  Ellis, Catherine Elizabeth

    IPC分类号： C12N15/12 ,  C07K14/705 ,  A61K38/17 ,  A61K31/70 ,  A61K48/00 ,  C12Q1/68 ,  G01N33/50 ,  G01N33/53 ,  G01N33/68

    CPC分类号： C07K14/705

    摘要： HFGAN72X polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HFGAN72X polypeptides and polynucleotides in the design of protocols for the treatment of infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; ulcers; asthma; allergies; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others and diagnostic assays for such conditions.

    CDNA Clone heoad54 that encodes a human 7 transmembrane receptor
    5.
    发明公开
    CDNA Clone heoad54 that encodes a human 7 transmembrane receptor 失效
    cDNA克隆Heoad54编码人7-跨膜食谱

    公开(公告)号：EP0892051A3

    公开(公告)日：2000-01-05

    申请号：EP98304192.2

    申请日：1998-05-27

    申请人： SMITHKLINE BEECHAM CORPORATION

    发明人： Mooney, Jeffrey L. ,  Bergsma, Derk J. ,  Halsey, Wendy S. ,  Sathe, Ganesh M.

    IPC分类号： C12N15/12 ,  C12N5/10 ,  C07K14/705 ,  C07K16/28 ,  A61K48/00 ,  A61K38/17 ,  C12Q1/68

    CPC分类号： C07K14/705 ,  A61K38/00

    摘要： HEOAD54 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HEOAD54 polypeptides and polynucleotides in the design of protocols for the treatment of infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; ulcers; asthma; allergies; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others, and diagnostic assays for such conditions.

    G-protein coupled receptor (HFGAN72X)
    6.
    发明公开
    G-protein coupled receptor (HFGAN72X) 失效
    G-protein-gekoppelter Rezeptor（HFGAN72X）

    公开(公告)号：EP1154019A2

    公开(公告)日：2001-11-14

    申请号：EP01203008.6

    申请日：1997-10-27

    申请人： SmithKline Beecham Corporation

    发明人： Bergsma, Derk J. ,  Ellis, Catherine Elizabeth

    IPC分类号： C12N15/12 ,  C07K14/705 ,  A61K38/17 ,  A61K31/70 ,  A61K48/00 ,  C12Q1/68 ,  G01N33/50 ,  G01N33/53 ,  G01N33/68

    CPC分类号： C07K14/705

    摘要： HFGAN72X polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HFGAN72X polypeptides and polynucleotides in the design of protocols for the treatment of infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; ulcers; asthma; allergies; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others and diagnostic assays for such conditions.

    摘要翻译： 公开了HFGAN72X多肽和多核苷酸以及通过重组技术产生此类多肽的方法。 还公开了在设计用于治疗感染例如细菌，真菌，原生动物和病毒感染，特别是由HIV-1或HIV-2引起的感染的方案中使用HFGAN72X多肽和多核苷酸的方法; 疼痛; 癌症; 厌食; 贪食症; 哮喘; 帕金森病; 急性心力衰竭 低血压; 高血压; 尿潴留 骨质疏松症; 心绞痛; 心肌梗死; 溃疡; 哮喘; 过敏; 良性前列腺肥大; 以及精神病和神经障碍，包括焦虑，精神分裂症，躁狂抑郁症，del妄，痴呆，严重的精神发育迟滞和运动障碍，如亨廷顿病或Gilles dela Tourett综合征等。

    Novel human 11CB splice variant
    7.
    发明公开
    Novel human 11CB splice variant 失效
    人文11CB剪接变异体

    公开(公告)号：EP0848060A2

    公开(公告)日：1998-06-17

    申请号：EP97309647.2

    申请日：1997-12-01

    申请人： SMITHKLINE BEECHAM CORPORATION

    发明人： Bergsma, Derk J. ,  Ellis, Catherine E.

    IPC分类号： C12N15/12 ,  C12N15/86 ,  C12N5/10 ,  C07K14/72 ,  C07K16/18 ,  C12Q1/68 ,  A61K31/70 ,  A61K38/17 ,  A61K48/00 ,  G01N33/50 ,  G01N33/68

    CPC分类号： C07K14/721 ,  A61K38/00 ,  C07K14/723

    摘要： Human 11cb splice variant polypeptides and DNA (RNA) encoding such an 11cb splice variant and a procedure for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing such an 11cb splice variant for the treatment of infections, such as bacterial, fungal, protozoan and viral infections, particularly infection caused by HIV-1 or HIV-2; pain; cancers; anorexia; bulimia; asthma; Parkinson's disease; both acute and congestive heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; ulcers; allergies; benign prostatic hypertrophy and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia or severe mental retardation; dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others. Antagonists against such an 11cb splice variant and their use as a therapeutic to treat infections, such as bacterial, fungal, protozoan and viral infections, particularly infaction caused by HIV-1 or HIV-2; pain; cancers; anorexia; bulimia; asthma; Parkinson's disease; both acute and congestive heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; ulcers; allergies; benign prostatic hypertrophy and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia or severe mental retardation; and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others, are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the 11cb splice variant and for detecting altered levels of the polypeptide in a host.

    Novel human 11CB splice variant
    8.
    发明公开
    Novel human 11CB splice variant 失效
    人道11CB拼接变体

    公开(公告)号：EP0848060A3

    公开(公告)日：2000-02-02

    申请号：EP97309647.2

    申请日：1997-12-01

    申请人： SMITHKLINE BEECHAM CORPORATION

    发明人： Bergsma, Derk J. ,  Ellis, Catherine E.

    IPC分类号： C12N15/12 ,  C12N15/85 ,  C12N5/10 ,  C12N1/21 ,  C07K14/72 ,  C07K16/28 ,  C12Q1/68 ,  A61K31/70 ,  A61K38/17 ,  A61K48/00 ,  G01N33/50 ,  G01N33/68

    CPC分类号： C07K14/721 ,  A61K38/00 ,  C07K14/723

    摘要： Human 11cb splice variant polypeptides and DNA (RNA) encoding such an 11cb splice variant and a procedure for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing such an 11cb splice variant for the treatment of infections, such as bacterial, fungal, protozoan and viral infections, particularly infection caused by HIV-1 or HIV-2; pain; cancers; anorexia; bulimia; asthma; Parkinson's disease; both acute and congestive heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; ulcers; allergies; benign prostatic hypertrophy and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia or severe mental retardation; dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others. Antagonists against such an 11cb splice variant and their use as a therapeutic to treat infections, such as bacterial, fungal, protozoan and viral infections, particularly infaction caused by HIV-1 or HIV-2; pain; cancers; anorexia; bulimia; asthma; Parkinson's disease; both acute and congestive heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; ulcers; allergies; benign prostatic hypertrophy and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia or severe mental retardation; and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others, are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the 11cb splice variant and for detecting altered levels of the polypeptide in a host.

    摘要翻译： 公开了人11cb剪接变体多肽和编码这种11cb剪接变体的DNA（RNA）和通过重组技术产生此类多肽的方法。 还公开了利用这种11cb剪接变体用于治疗诸如细菌，真菌，原生动物和病毒感染，特别是由HIV-1或HIV-2引起的感染的感染的方法。 疼痛; 癌症; 厌食; 贪食症; 哮喘; 帕金森病; 急性和充血性心力衰竭; 低血压; 高血压; 尿潴留 骨质疏松症; 心绞痛; 心肌梗死; 溃疡; 过敏; 良性前列腺肥大和精神病和神经障碍，包括焦虑，精神分裂症，躁狂抑郁，del妄，痴呆或严重智力迟钝; 运动障碍，如亨廷顿舞蹈症或吉列斯·达拉图雷特综合征等。 对抗这种11cb剪接变体的拮抗剂及其用作治疗性感染的用途，例如细菌，真菌，原生动物和病毒感染，特别是由HIV-1或HIV-2引起的疾病; 疼痛; 癌症; 厌食; 贪食症; 哮喘; 帕金森病; 急性和充血性心力衰竭; 低血压; 高血压; 尿潴留 骨质疏松症; 心绞痛; 心肌梗死; 溃疡; 过敏; 良性前列腺肥大和精神病和神经障碍，包括焦虑，精神分裂症，躁狂抑郁，del妄，痴呆或严重智力迟钝; 以及运动障碍，如亨廷顿舞蹈病（Gilles dela Tourett）综合征等。 还公开了用于检测与核酸序列中的突变和多肽的改变的浓度相关的疾病的诊断测定。 还公开了用于检测编码11cb剪接变体的多核苷酸中的突变并用于检测宿主中多肽的改变水平的诊断测定法。

    CDNA Clone heoad54 that encodes a human 7 transmembrane receptor
    9.
    发明公开
    CDNA Clone heoad54 that encodes a human 7 transmembrane receptor 失效
    CDNA Klon Heoad54 derfüreinen menschlichen 7-Transmembranrezeptur kodiert

    公开(公告)号：EP0892051A2

    公开(公告)日：1999-01-20

    申请号：EP98304192.2

    申请日：1998-05-27

    申请人： SMITHKLINE BEECHAM CORPORATION

    发明人： Mooney, Jeffrey L. ,  Bergsma, Derk J. ,  Halsey, Wendy S. ,  Sathe, Ganesh M.

    IPC分类号： C12N15/12 ,  C12N5/10 ,  C07K14/705 ,  C07K16/28 ,  A61K48/00 ,  A61K38/17 ,  C12Q1/68

    CPC分类号： C07K14/705 ,  A61K38/00

    摘要： HEOAD54 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HEOAD54 polypeptides and polynucleotides in the design of protocols for the treatment of infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; ulcers; asthma; allergies; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others, and diagnostic assays for such conditions.

    摘要翻译： 公开了HEOAD54多肽和多核苷酸以及通过重组技术产生此类多肽的方法。 还公开了在设计用于治疗感染例如细菌，真菌，原生动物和病毒感染，特别是由HIV-1或HIV-2引起的感染的方案中使用HEOAD54多肽和多核苷酸的方法; 疼痛; 癌症; 厌食; 贪食症; 哮喘; 帕金森病; 急性心力衰竭 低血压; 高血压; 尿潴留 骨质疏松症; 心绞痛; 心肌梗死; 溃疡; 哮喘; 过敏; 良性前列腺肥大; 以及精神病和神经障碍，包括焦虑，精神分裂症，躁狂抑郁，del妄，痴呆，严重的精神发育迟滞和运动障碍，如亨廷顿病或Gilles dela Tourett综合征等，以及这些病症的诊断测定。

    CDNA clone HNFDY20 that encodes a novel human 7-transmembrane receptor
    10.
    发明公开
    CDNA clone HNFDY20 that encodes a novel human 7-transmembrane receptor 失效
    HNFDY20 cDNS Klon，dasfüreinen neuen menschlichen 7-Transmembran-Rezeptor kodiert

    公开(公告)号：EP0866126A1

    公开(公告)日：1998-09-23

    申请号：EP98301122.2

    申请日：1998-02-16

    申请人： SMITHKLINE BEECHAM CORPORATION

    发明人： Bergsma, Derk J. ,  Sathe, Ganesh M. ,  Fuetterer, Wendy S. ,  Mao, Joyce Y.

    IPC分类号： C12N15/12 ,  C07K14/705 ,  A61K38/17 ,  G01N33/74 ,  C12Q1/68 ,  C07K16/28 ,  C12N15/11 ,  A61K48/00

    CPC分类号： C07K14/705 ,  A61K38/00 ,  A61K48/00

    摘要： HNFDY20 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HNFDY20 polypeptides and polynucleotides in the design of protocols for the treatment of infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; ulcers; asthma; allergies; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others and diagnostic assays for such conditions.

    摘要翻译： HNFDY20多肽和多核苷酸以及通过重组技术产生此类多肽的方法。 还公开了在设计用于治疗感染例如细菌，真菌，原生动物和病毒感染，特别是由HIV-1或HIV-2引起的感染的方案中使用HNFDY20多肽和多核苷酸的方法; 疼痛; 癌症; 厌食; 贪食症; 哮喘; 帕金森病; 急性心力衰竭 低血压; 高血压; 尿潴留 骨质疏松症; 心绞痛; 心肌梗死; 溃疡; 哮喘; 过敏; 良性前列腺肥大; 以及精神病和神经障碍，包括焦虑，精神分裂症，躁狂抑郁症，del妄，痴呆，严重的精神发育迟滞和运动障碍，如亨廷顿病或Gilles dela Tourett综合征等。