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    PROCESS FOR THE PREPARATION OF ESTERS OF 1-SUBSTITUTED-3-FLUOROALKYL-PYRAZOLE-4-CARBOXYLIC ACIDS
    1.
    发明授权
    PROCESS FOR THE PREPARATION OF ESTERS OF 1-SUBSTITUTED-3-FLUOROALKYL-PYRAZOLE-4-CARBOXYLIC ACIDS 有权

    公开(公告)号：EP2595962B1

    公开(公告)日：2018-07-11

    申请号：EP11737935.4

    申请日：2011-07-22

    申请人： SOLVAY SA

    发明人： BRAUN, Max Josef ,  JAUNZEMS, Janis

    IPC分类号： C07D231/14

    CPC分类号： C07D231/14

    摘要： A process for the manufacture of an ester or the respective free acid of a 1-substituted-3-fluoroalkyl-pyrazole-4-carboxylic acid of formula (I), wherein in such formula (I), Y is H, F or an alkyl group having from 1 to 12 carbon atoms which is optionally substituted by at least one halogen atom, an aralkyl group or an aryl group; R1 is H or an organic residue; R2 is H or an organic residue. Such process comprises submitting a compound of formula (II) to a reduction reaction, wherein in such formula (II), Y is the same as defined for formula (I); X is Cl, Br or I; R1′ is H or an organic residue; and R2′ is H or an organic residue.

    PROCESS FOR THE PREPARATION OF PYRAZOLE-4-CARBOXAMIDES
    2.
    发明公开
    PROCESS FOR THE PREPARATION OF PYRAZOLE-4-CARBOXAMIDES 审中-公开
    制备吡唑-4-羧酰胺的方法

    公开(公告)号：EP3174857A1

    公开(公告)日：2017-06-07

    申请号：EP15745446.3

    申请日：2015-07-29

    申请人： Solvay SA

    发明人： BRAUN, Max Josef

    IPC分类号： C07D231/14

    CPC分类号： C07D231/14

    摘要： The invention concerns a process for the manufacture of pyrazole-4-carboxamides, in particular, of 3-difluoromethyl-1-methyl-1 H-pyrazole-4-carboxamides which are useful as pharmaceuticals and agrochemicals. The carboxamides are prepared from the corresponding pyzole-4-carboxylic acid esters and appropriate amine in the presence of a Lewis acid. Alternatively, the reaction is performed in the presence of a Lewis acid and a base.

    摘要翻译： 本发明涉及制备可用作药物和农业化学品的吡唑-4-甲酰胺，特别是3-二氟甲基-1-甲基-1H-吡唑-4-甲酰胺的方法。 该酰胺由路易斯酸存在下由相应的吡唑-4-羧酸酯和适当的胺制备。 或者，该反应在路易斯酸和碱存在下进行。

    PROCESS FOR THE MANUFACTURE OF FLUOROMETHOXYMALONIC ACID DERIVATIVES
    4.
    发明公开
    PROCESS FOR THE MANUFACTURE OF FLUOROMETHOXYMALONIC ACID DERIVATIVES 有权
    用于制造氟代甲氧基丙二酸衍生物的方法

    公开(公告)号：EP2673256A1

    公开(公告)日：2013-12-18

    申请号：EP12702050.1

    申请日：2012-02-07

    申请人： Solvay SA

    发明人： BRAUN, Max Josef ,  CLAASSEN, Uta

    IPC分类号： C07C67/307 ,  C07C69/708 ,  C07C41/22

    CPC分类号： C07C67/287 ,  C07C41/01 ,  C07C67/307 ,  C07C69/708

    摘要： Process for the manufacture of a compound of formula R1OOC-CH(OCH2F)-COOR, (I) or R3HNOC-CH(OCH2F)-CONHR4(II) wherein R1, R2, R3, R4 are equal or different from each other and are independently selected from H; an alkyl group having from 1 to 10 carbon atoms which is optionally substituted by at least one halogen atom; an aralkyl group; or an aryl group, comprising reacting a compound of formula R1OOC-CH(OCH2X)-COOR2 (III) or R3HNOC-CH(OCH2X)-CONHR4(IV) wherein X is a leaving group that can be substituted by nucleophilic substitution, and wherein R1, R2, R3, R4 have the same meaning as above, with at least one source of nucleophilic fluorine.

    摘要翻译： 制备式R1OOC-CH（OCH2F）-COOR，（I）或R3HNOC-CH（OCH2F）-CONHR4（II）的化合物的方法，其中R1，R2，R3，R4彼此相同或不同且为 独立地选自H; 具有1至10个碳原子的烷基，其任选被至少一个卤素原子取代; 芳烷基; （OCH 2 X）-COOR 2（III）或R 3 HNOC-CH（OCH 2 X）-CONHR 4（IV）的化合物进行反应，其中X是可以被亲核取代取代的离去基团，并且其中 R1，R2，R3，R4具有与上述相同的含义，与至少一种亲核性氟来源。

    PROCESS FOR THE PREPARATION OF ESTERS OF 1-SUBSTITUTED-3-FLUOROALKYL-PYRAZOLE-4-CARBOXYLIC ACIDS
    5.
    发明公开
    PROCESS FOR THE PREPARATION OF ESTERS OF 1-SUBSTITUTED-3-FLUOROALKYL-PYRAZOLE-4-CARBOXYLIC ACIDS 有权
    用于生产选自酯1-取代-3-氟代烷基吡唑-4-羧酸

    公开(公告)号：EP2595962A1

    公开(公告)日：2013-05-29

    申请号：EP11737935.4

    申请日：2011-07-22

    申请人： SOLVAY SA

    发明人： BRAUN, Max Josef ,  JAUNZEMS, Janis

    IPC分类号： C07D231/14

    CPC分类号： C07D231/14

    摘要： A process for the manufacture of an ester or the respective free acid of a 1-substituted-3-fluoroalkyl-pyrazole-4-carboxylic acid of formula (I), wherein in such formula (I), Y is H, F or an alkyl group having from 1 to 12 carbon atoms which is optionally substituted by at least one halogen atom, an aralkyl group or an aryl group; R1 is H or an organic residue; R2 is H or an organic residue. Such process comprises submitting a compound of formula (II) to a reduction reaction, wherein in such formula (II), Y is the same as defined for formula (I); X is Cl, Br or I; R1′ is H or an organic residue; and R2′ is H or an organic residue.