公开(公告)号：EP1181582A2

公开(公告)日：2002-02-27

申请号：EP99974262.0

申请日：1999-11-02

申请人： SPECTRX, Inc.

发明人： LINCOLN, Danny ,  HARRELL, Tim ,  KUMAR, Krishna ,  PAPP, Joseph ,  FARQUHAR, David

IPC分类号： G02B1/00

CPC分类号： G02B6/04 ,  A61B2018/2211

摘要： A fiber optic probe (110) is provided that includes a housing (160), at least one optical fiber (120) disposed within the housing, one end of each of the at least one optical fiber being disposed adjacent an opening in the housing forming a probe face, a binding agent (130) that binds the at least one optical fiber within the housing, and a protective coating (150) sealingly covering the probe face to prevent contaminants from contacting the at least one optical fiber. A method for protecting a fiber optic probe having a housing, at least one optical fiber being disposed adjacent an opening in the housing forming a probe face, and a binding agent that binds the at least one optical fiber within the housing, includes polishing the probe face to create a substantially flat probe face, cleaning the probe face after polishing the probe face and sealing the probe face with a protective coating.

公开(公告)号：EP1173746A1

公开(公告)日：2002-01-23

申请号：EP00917869.0

申请日：2000-03-24

申请人： SPECTRX, Inc.

发明人： ARCHE, Glen, Steven ,  BAMBOT, Shabbir, B. ,  FARQUHAR, David ,  FAUPEL, Mark, L. ,  HARRELL, Tim ,  SANDERS, Walter, R. ,  KIMBRELL, Edward, L.

IPC分类号： G01N21/00

CPC分类号： G01N21/474 ,  A61B5/0059 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0091 ,  A61B5/4312 ,  A61B5/444 ,  A61B5/6843 ,  A61B2562/164 ,  G01N21/21 ,  G01N21/49 ,  G01N21/64

摘要： An apparatus embodying the invention includes a probe head (304) with an interrogation surface that is intended to be positioned adjacent or pushed into contact with a target material or tissue (50). The probe head (304) is constructed to have a plurality of interrogation devices (317) arranged across the face of the interrogation surface. The probe head (304) is also constructed so that the interrogation device can conform to a non-uniform or non-planar surface of the target tissue (50). In some embodiments, the interrogation surface may have a particular shape that conforms to the shape of a target material. In other embodiments, one or more portions of the interrogation surface could be movable with respect to remaining portions so that the interrogation surface can thereby conform to a non-uniform surface. In still other embodiments, a plurality of separately moveable interrogation devices can be arranged across the interrogation surface. During a measurement process, the interrogation surface would be pressed into contact with the uniform surface to cause individual ones of the interrogation devices to move, thereby causing the probe head to conform to the non-uniform surface.

公开(公告)号：EP1229825B1

公开(公告)日：2012-06-20

申请号：EP00980533.4

申请日：2000-11-17

申请人： SpectRx, Inc. ,  Altea Therapeutics Corporation

发明人： FAUPEL, Mark, L. ,  KUMAR, Krishna ,  FARQUHAR, David ,  VREEKE, Mark ,  SMITH, Alan ,  HATCH, Michael ,  WOODS, Teresa

IPC分类号： A61B5/1486

CPC分类号： A61B5/1486

摘要： A tissue interface device (10) suitable for positioning on or about one or more artificial openings in a biological membrane of an organism and for coupling to a monitor and control unit and a vacuum source. The tissue interface device (10) comprises a housing (100), a sensor channel (130), and a sensor (150). The housing (100) defines an orifice (120), the orifice (120) having an open inlet port (122) on the bottom end (102) of the housing (100) and a distal end (124) that is in fluid communication with the sensor channel (130). The orifice (120) is in fluid communication with fluid that flows from the artificial opening formed in the biological membranes. The sensor channel (130) is for coupling to, and fluid communication therewith, the vacuum source. The sensor (150) is positioned in the sensor channel (130) in a flow path of the fluid for sensing a characteristic of the fluid as it flows out from the artificial opening. The sensor generates a sensor signal representative thereof.

公开(公告)号：EP1098589B1

公开(公告)日：2006-02-22

申请号：EP99935678.5

申请日：1999-07-20

申请人： SpectRx, Inc. ,  Altea Therapeutics Corporation

发明人： SMITH, Alan ,  DELCHER, Harry, K. ,  EPPSTEIN, Jonathan, A. ,  FARQUHAR, David ,  HATCH, Michael, R. ,  KUMAR, Krishna, S.

IPC分类号： A61B5/00

CPC分类号： A61B5/412 ,  A61B5/00 ,  A61B5/14514 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150099 ,  A61B5/150221 ,  A61B5/150358 ,  A61B5/150969 ,  A61B5/155 ,  A61B5/157 ,  A61B2017/00172

摘要： A fluid collection and sensor device for placement over at least one artificial opening made in a biological membrane for measuring a characteristic of a biological fluid collected from the tissue through the at least one artificial opening. The device comprises a sensor (110) positioned in a flow path (105) of the biological fluid for contacting a quantity of the biological fluid and generating an indication of a characteristic of the biological fluid. According to one aspect of the invention, a waste fluid storage element (120), such as a reservoir, is positioned in the device (100) to collect the biological fluid after it has made contact with the sensor (110). According to another aspect of the invention, various surfaces of the fluid flow path (105) of the fluid collection and sensor device (100) are treated with an agent to limit or minimize clotting, aggregation or sepsis of the biological fluid, blockage or clogging of the flow path (105) or degradation of the sensor (110). According to still another aspect of the invention, various configurations of a fluid sensor and collection device (100) are provided that are designed to ensure that measurements are made on independent fluid samples.

公开(公告)号：EP1229825A1

公开(公告)日：2002-08-14

申请号：EP00980533.4

申请日：2000-11-17

申请人： SPECTRX, Inc. ,  Altea Technologies, Inc.

发明人： FAUPEL, Mark, L. ,  KUMAR, Krishna ,  FARQUHAR, David ,  VREEKE, Mark ,  SMITH, Alan ,  HATCH, Michael ,  WOODS, Teresa

IPC分类号： A61B5/00

CPC分类号： A61B5/1486

摘要： A tissue interface device (10) suitable for positioning on or about one or more artificial openings in a biological membrane of an organism and for coupling to a monitor and control unit and a vacuum source. The tissue interface device (10) comprises a housing (100), a sensor channel (130), and a sensor (150). The housing (100) defines an orifice (120), the orifice (120) having an open inlet port (122) on the bottom end (102) of the housing (100) and a distal end (124) that is in fluid communication with the sensor channel (130). The orifice (120) is in fluid communication with fluid that flows from the artificial opening formed in the biological membranes. The sensor channel (130) is for coupling to, and fluid communication therewith, the vacuum source. The sensor (150) is positioned in the sensor channel (130) in a flow path of the fluid for sensing a characteristic of the fluid as it flows out from the artificial opening. The sensor generates a sensor signal representative thereof.

公开(公告)号：EP1098589A1

公开(公告)日：2001-05-16

申请号：EP99935678.5

申请日：1999-07-20

申请人： SPECTRX, Inc.

发明人： SMITH, Alan ,  DELCHER, Harry, K. ,  EPPSTEIN, Jonathan, A. ,  FARQUHAR, David ,  HATCH, Michael, R. ,  KUMAR, Krishna, S.

IPC分类号： A61B5/00

CPC分类号： A61B5/412 ,  A61B5/00 ,  A61B5/14514 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150099 ,  A61B5/150221 ,  A61B5/150358 ,  A61B5/150969 ,  A61B5/155 ,  A61B5/157 ,  A61B2017/00172

摘要： A fluid collection and sensor device for placement over at least one artificial opening made in a biological membrane for measuring a characteristic of a biological fluid collected from the tissue through the at least one artificial opening. The device comprises a sensor (110) positioned in a flow path (105) of the biological fluid for contacting a quantity of the biological fluid and generating an indication of a characteristic of the biological fluid. According to one aspect of the invention, a waste fluid storage element (120), such as a reservoir, is positioned in the device (100) to collect the biological fluid after it has made contact with the sensor (110). According to another aspect of the invention, various surfaces of the fluid flow path (105) of the fluid collection and sensor device (100) are treated with an agent to limit or minimize clotting, aggregation or sepsis of the biological fluid, blockage or clogging of the flow path (105) or degradation of the sensor (110). According to still another aspect of the invention, various configurations of a fluid sensor and collection device (100) are provided that are designed to ensure that measurements are made on independent fluid samples.