专利检索 ap:("SYMEX CORP.") AND inv:"MAHER, JAMES, F." 第 1 页

1.

发明公开
METHODS FOR DIAGNOSTING HUMAN INFLUENZA AND 4-POSITION MODIFIED CHROMOGENIC N-ACETYLNEURAMINIC ACID SUBSTRATES FOR USE THEREIN 失效
标题翻译：用于诊断人类流感和4位改性的色氨酸N-乙酰氨基酸基质的方法

公开(公告)号：EP0507854A4

公开(公告)日：1992-10-21

申请号：EP91902414

申请日：1990-12-27

申请人： SYMEX CORP.

发明人： TURNER, GREGORY, A. , MAHER, JAMES, F. , CLINKSCALES, C., WORTH , ROARK, MICHAEL, C.

IPC分类号： C07H13/04 , C07H15/04 , C07H15/203 , C07H17/02 , C07H17/04 , C07H17/075 , C12Q1/34 , G01N33/52 , C07H17/00

CPC分类号： C07H13/04 , C07H15/04 , C07H15/203 , C07H17/02 , C07H17/075 , C12Q1/34 , G01N33/52 , G01N2333/11 , G01N2333/924

摘要： Chromogenic derivatives of N-acetylneuraminic acid modified in the 4-position by eliminating the hydroxyl group, by replacing the hydroxyl group with fluorine, or by replacing the hydrogen of the hydroxyl group with methyl are used as substrates in colorimetric assays for human influenza neuraminidase activity in clinical specimens for the purpose of selectively diagnosing influenza infection. The substrates may exhibit different reactivity with the different types of influenza neuraminidases, thus enabling one to discern the specific type of influenza infection and prescribe appropriate treatment and/or supportive therapy therefor.