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1.发明公开AMPHIPHILIC BLOCK COPOLYMER AND POLYMERIC COMPOSITION COMPRISING THE SAME FOR DRUG DELIVERY 有权两亲嵌段共聚物和含有聚合物组合物用于药物供
公开(公告)号：EP1670838A1
公开(公告)日：2006-06-21
申请号：EP04793450.0
申请日：2004-10-08
申请人： Samyang Corporation
发明人： SEO, Min-Hyo , KIM, Bong-Oh , CHOI, In-Ja , SHIM, Myung-Seob , LEE, Sa-Won , HYUN, Myung-Han , YU, Jung-Il , CHANG, Dong-Hoon , KIM, Jeong-Kyung , YOON, Hye-Jeong
IPC分类号： C08F293/00 , A61K31/77 , A61K47/34
CPC分类号： A61K9/1075 , A61K31/77 , C08F293/00
摘要： The present invention relates to an amphiphilic block copolymer of a hydrophilic block and a hydrophobic block with a terminal hydroxyl group wherein the terminal hydroxyl group of the hydrophobic bock is substituted with a tocopherol or cholesterol group. It also relates to polymeric compositions capable of forming stable micelles in an aqueous solution, comprising the amphiphilic block copolymer and a polylactic acid derivative wherein one or more ends of the polylactic acid are covalently bound to at least one carboxyl group.
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2.发明授权BIODEGRADABLE BRANCHED POLYLACTIDE DERIVATIVESCAPABLE OF FORMING POLYMERIC MICELLES, AND THEIR PREPARATION METHOD AND USE 有权可生物降解的启用支化POLYLACTIDDERIVATE THAT教育聚合物胶束过程用于其与用来生成
公开(公告)号：EP1633797B1
公开(公告)日：2010-01-27
申请号：EP04808305.9
申请日：2004-12-03
申请人： Samyang Corporation
发明人： SEO, Min-Hyo , KIM, Bong-Oh , CHOI, In-Ja , SHIM, Myung-Seob
IPC分类号： C08G63/08 , C08F297/00 , C08G85/00 , C08L67/04
CPC分类号： A61K9/1075 , A61K47/34 , C08G63/08 , C08G63/78 , C08G63/912
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3.发明公开BIODEGRADABLE MULTI-BLOCK POLYMERIC COMPOSITION CAPABLE OF SOL-GEL TRANSITION 有权更可生物降解的嵌段聚合物组合物进行溶胶 - 凝胶转变启用
公开(公告)号：EP1773908A1
公开(公告)日：2007-04-18
申请号：EP05771162.4
申请日：2005-08-01
申请人： Samyang Corporation
发明人： SEO, Min-Hyo , KIM, Bong-Oh , SHIM, Myung-Seob , LEE, Sang-Jun
IPC分类号： C08G63/16 , C08G63/676 , C08G65/332
CPC分类号： C08G65/3344 , A61K9/0019 , A61K9/06 , A61K38/193 , A61K38/212 , A61K38/27 , A61K47/60 , C07K14/56 , C07K14/61 , C08G63/672 , C08G65/3322 , C08G65/3326 , C08G65/3353 , C08G2261/126
摘要： The present invention relates to an ionic multi-block copolymer composition comprising tri-block copolymers having a polypropyleneoxide or polybutyleneoxide block positioned between two polyethyleneoxide blocks and the tri-block copolymers are connected through dicarboxylic acid linkages forming a multi-block copolymer having a weight average molecular weight of more than 40,000 Dalton. The higher weight average molecular weight enables the hydrolgel formed from the multi-block copolymer of the present invention to maintain its gel status for more than several days.
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4.发明公开BIODEGRADABLE BRANCHED POLYLACTIDE DERIVATIVESCAPABLE OF FORMING POLYMERIC MICELLES, AND THEIR PREPARATION METHOD AND USE 有权可生物降解的启用支化POLYLACTIDDERIVATE THAT教育聚合物胶束过程用于其与用来生成
公开(公告)号：EP1633797A1
公开(公告)日：2006-03-15
申请号：EP04808305.9
申请日：2004-12-03
申请人： Samyang Corporation
发明人： SEO, Min-Hyo , KIM, Bong-Oh , CHOI, In-Ja , SHIM, Myung-Seob
IPC分类号： C08G63/08 , C08F297/00 , C08G85/00 , C08L67/04
CPC分类号： A61K9/1075 , A61K47/34 , C08G63/08 , C08G63/78 , C08G63/912
摘要： The present invention relates to a biodegradable branched polylactic acid derivative of formula 1, and preparation method and use thereof: 1-(R-X)n wherein each of X, R, I and n is defined as in the detailed description.
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公开(公告)号：EP1978975A1
公开(公告)日：2008-10-15
申请号：EP07701070.0
申请日：2007-02-01
申请人： Samyang Corporation
发明人： CHOI, In-Ja , SEO, Min-Hyo , KIM, Bong-Oh , SHIM, Myung-Seob
IPC分类号： A61K31/765 , A61P41/00
CPC分类号： A61K31/765 , A61L26/0019 , A61L26/0076 , A61L26/008 , A61L31/06 , A61L31/145 , C08L71/02
摘要： There is provided in the present invention a composition for inhibiting adhesion comprising polymers that are dissolved in an aqueous solution and have temperature sensitivity showing a sol-gel phase transition dependant upon temperature, wherein the polymer solution in a sol state becomes a gel state by body temperature and is thus stably coated within tissues whereby it functions as a membrane inhibiting adhesion and as time lapses, it is degraded into low molecular weight surfactants and bio-degradable single molecular substances whereby they can be absorbed into body and the degraded products can bring about secondary adhesion inhibiting effects.
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6.发明授权PH RESPONSIVE BIODEGRADABLE POLYLACTIC ACID DERIVATIVES FORMING POLYMERIC MICELLES AND USES THEREOF FOR POORLY WATER SOLUBLE DRUG DELIVERY 有权pH响应的生物可降解POLYMILCHSÄUREDERIVATE，使聚合物胶束和它们用于供应不良水溶性的药物
公开(公告)号：EP1448710B1
公开(公告)日：2007-03-28
申请号：EP02788877.5
申请日：2002-10-17
申请人： Samyang Corporation
发明人： SEO, Min-Hyo , KIM, Bong-Oh , CHOI, In-Ja , SHIM, Myung-Seob
CPC分类号： C08G63/78 , A61K9/1075 , C08G63/06
摘要： Polylactic acid derivatives capable of forming micelles in an aqueous solution with a pH of 4 or above, having one terminal carboxyl group. The polylactic acid derivatives may be applied as a drug delivery system in various forms since poorly water soluble drugs can be entrapped inside the micelles.
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7.发明公开PH RESPONSIVE BIODEGRADABLE POLYLACTIC ACID DERIVATIVES FORMING POLYMERIC MICELLES AND USES THEREOF FOR POORLY WATER SOLUBLE DRUG DELIVERY 有权pH响应的生物可降解POLYMILCHSÄUREDERIVATEWHICH MAKE聚合物胶束和它们用于供应不良水溶性的药物
公开(公告)号：EP1448710A1
公开(公告)日：2004-08-25
申请号：EP02788877.5
申请日：2002-10-17
申请人： Samyang Corporation
发明人： SEO, Min-Hyo , KIM, Bong-Oh , CHOI, In-Ja , SHIM, Myung-Seob
CPC分类号： C08G63/78 , A61K9/1075 , C08G63/06
摘要： Polylactic acid derivatives capable of forming micelles in an aqueous solution with a pH of 4 or above, having one terminal carboxyl group. The polylactic acid derivatives may be applied as a drug delivery system in various forms since poorly water soluble drugs can be entrapped inside the micelles.
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