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1.发明授权ADAMANTANE AND AZABICYCLO-OCTANE AND NONANE DERIVATIVES PROCESS OF THEIR PREPARATION AND THEIR USE AS DPP-IV INHIBITORS 有权金刚烷AZABICYCLOOCTAN-和-NONANDERIVATE，方法及其及其作为DPP-IV抑制剂
公开(公告)号：EP1664031B1
公开(公告)日：2007-12-19
申请号：EP04769087.0
申请日：2004-08-27
申请人： Sanofi-Aventis
发明人： ARÁNYI, Péter , BATA, Imre , BÁTORI, Sándor , BORONKAY, Éva , BOVY, Philippe , KAPUI, Zoltán , SUSÁN, Edit , SZABÓ, Tibor , URBÁN-SZABÓ, Katalin , VARGA, Márton
IPC分类号： C07D403/12 , C07D207/16 , C07D417/12 , C07D413/12 , C07D401/12 , C07D471/04 , C07D409/12 , C07D253/06 , C07D241/20 , C07D213/74 , C07D277/42 , C07D231/38 , C07D261/14 , C07D215/38
CPC分类号： C04B35/632 , C07D207/16 , C07D213/74 , C07D215/38 , C07D221/22 , C07D231/38 , C07D241/20 , C07D253/06 , C07D261/14 , C07D277/42 , C07D401/12 , C07D403/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D451/02 , C07D471/04
摘要： The invention relates to new compounds of the general formula (I), which are strong DPP-IV enzyme inhibitors.
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公开(公告)号：EP1699454A1
公开(公告)日：2006-09-13
申请号：EP04806274.9
申请日：2004-12-15
申请人： Sanofi-Aventis
发明人： ALETRU, Michel , ARÁNYI, Péter , BALOGH, Mária , BÁTORI, Sándor , BENCE, Judit , BOVY, Philippe , KAPUI, Zoltán , MIKUS, Endre , NAMANE, Claudie , PHILIPPO, Christophe , SZABÓ, Tibor , TÖMÖSKÖZI, Zsuzsanna , URBÁN-SZABÓ, Katalin
IPC分类号： A61K31/415 , A61K31/4155 , C07D401/12 , C07D231/16 , C07D471/04 , C07D413/12 , C07D403/12 , C07D417/12 , C07D401/04 , C07D401/14 , C07D409/12 , C07D409/14 , A61P1/14 , A61P25/00
CPC分类号： C07D409/04 , C07D231/16 , C07D231/56 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14
摘要： The present invention relates to the orexin receptor antagonists compounds of the general formula (I) as well as to their isomers, salts and solvates, to the pharmaceutical compositions containing them and to the therapeutic application thereof.
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3.发明公开ADAMANTANE AND AZABICYCLO-OCTANE AND NONANE DERIVATIVES PROCESS OF THEIR PREPARATION AND THEIR USE AS DPP-IV INHIBITORS 有权金刚烷AZABICYCLOOCTAN-和-NONANDERIVATE，方法及其及其作为DPP-IV抑制剂
公开(公告)号：EP1664031A2
公开(公告)日：2006-06-07
申请号：EP04769087.0
申请日：2004-08-27
申请人： Sanofi-Aventis
发明人： ARÁNYI, Péter , BATA, Imre , BÁTORI, Sándor , BORONKAY, Éva , BOVY, Philippe , KAPUI, Zoltán , SUSÁN, Edit , SZABÓ, Tibor , URBÁN-SZABÓ, Katalin , VARGA, Márton
IPC分类号： C07D403/12 , C07D207/16 , C07D417/12 , C07D413/12 , C07D401/12 , C07D471/04 , C07D409/12 , C07D253/06 , C07D241/20 , C07D213/74 , C07D277/42 , C07D231/38 , C07D261/14 , C07D215/38
CPC分类号： C04B35/632 , C07D207/16 , C07D213/74 , C07D215/38 , C07D221/22 , C07D231/38 , C07D241/20 , C07D253/06 , C07D261/14 , C07D277/42 , C07D401/12 , C07D403/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D451/02 , C07D471/04
摘要： The invention relates to new compounds of the general formula (I), which are strong DPP-IV enzyme inhibitors.
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公开(公告)号：EP2167470B1
公开(公告)日：2011-03-16
申请号：EP08762666.9
申请日：2008-06-02
申请人： Sanofi-Aventis
发明人： SUSÁN, Edit , BOÉR, Kinga , KAPUI, Zoltán , TIMÁRI, Géza , BÁTORI, Sándor , SZLÁVIK, Zoltán , MIKUS, Endre , VARGÁNÉ SZEREDI, Judit , FINET, Michel , URBÁN SZABÓ, Katalin , SZABÓ, Tibor
IPC分类号： C07D215/58 , C07D471/04 , C07F7/22 , A61K31/4745 , A61P11/06 , A61P29/00
CPC分类号： C07D471/04
摘要： The present invention relates to the adenosine A3 receptor ligands of the general formula (I), within them favourably to the antagonists, to their salts, solvates,
N -oxides and isomers, to the pharmaceutical compositions containing the compounds of the general formula (I), their salts, solvates,
N -oxides and isomers, to the use of the compounds of the general formula (I), their salts, solvates,
N -oxides and isomers, to the preparation of the compounds of the general formula (I), their salts, solvates,
N -oxides and isomers, as well as to the new intermediates of the general formula (II), (VI), (XI), (XII) and (XV), and to the preparation thereof.-
公开(公告)号：EP1931627A1
公开(公告)日：2008-06-18
申请号：EP06795035.2
申请日：2006-09-19
申请人： Sanofi-Aventis
发明人： PAPPNÉ BEHR, Ágnes , KAPUI, Zoltán , ARÁNYI, Péter , BÁTORI, Sándor , BARTÁNÉ BODOR, Veronika , VARGA, Márton , FERENCZY, György , MIKUS, Endre , URBÁN-SZABÓ, Katalin , VARGÁNÉ SZEREDI, Judit , SZABÓ, Tibor , WALCZ, Erszébet
IPC分类号： C07C323/63 , C07C233/35 , A61K31/4965
CPC分类号： C07C323/60 , C07D209/30 , C07D233/84 , C07D235/28 , C07D239/34 , C07D239/38 , C07D241/44 , C07D257/04 , C07D263/58 , C07D271/113 , C07D277/16 , C07D277/70 , C07D401/04 , C07D405/04 , C07D413/04 , C07D471/04 , C07D513/04
摘要： The present invention relates to the CCR3 receptor ligands of the general formula (I), within them favourably to antagonists and to the salts, solvates and isomers thereof, to the pharmaceutical compositions containing them, to the use of the compounds of the general formula (I) and their salts, solvates and isomers, to the preparation of the compounds of the general formula (I) and their salts, solvates and isomers and to the new intermediates of the general formula (III).
摘要翻译： 本发明涉及通式（I）的CCR3受体配体，在其中有利地涉及拮抗剂及其盐，溶剂化物和异构体，含有它们的药物组合物，涉及通式 I）化合物及其盐，溶剂合物和异构体用于制备通式（I）化合物及其盐，溶剂化物和异构体以及通式（III）的新中间体。
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公开(公告)号：EP2167470A1
公开(公告)日：2010-03-31
申请号：EP08762666.9
申请日：2008-06-02
申请人： Sanofi-Aventis
发明人： SUSÁN, Edit , BOÉR, Kinga , KAPUI, Zoltán , TÍMÁRI, Géza , BÁTORI, Sándor , SZLÁVIK, Zoltán , MIKUS, Endre , VARGÁNÉ SZEREDI, Judit , FINET, Michel , URBÁN SZABÓ, Katalin , SZABÓ, Tibor
IPC分类号： C07D215/58 , C07D471/04 , C07F7/22 , A61K31/4745 , A61P11/06 , A61P29/00
CPC分类号： C07D471/04
摘要： The present invention relates to the adenosine A3 receptor ligands of the general formula (I), within them favourably to the antagonists, to their salts, solvates,
N -oxides and isomers, to the pharmaceutical compositions containing the compounds of the general formula (I), their salts, solvates,
N -oxides and isomers, to the use of the compounds of the general formula (I), their salts, solvates,
N -oxides and isomers, to the preparation of the compounds of the general formula (I), their salts, solvates,
N -oxides and isomers, as well as to the new intermediates of the general formula (II), (VI), (XI), (XII) and (XV), and to the preparation thereof.-
公开(公告)号：EP1699454B1
公开(公告)日：2009-08-05
申请号：EP04806274.9
申请日：2004-12-15
申请人： Sanofi-Aventis
发明人： ALETRU, Michel , ARÁNYI, Péter , BALOGH, Mária , BÁTORI, Sándor , BENCE, Judit , BOVY, Philippe , KAPUI, Zoltán , MIKUS, Endre , NAMANE, Claudie , PHILIPPO, Christophe , SZABÓ, Tibor , TÖMÖSKÖZI, Zsuzsanna , URBÁN-SZABÓ, Katalin
IPC分类号： A61K31/415 , A61K31/4155 , C07D401/12 , C07D231/16 , C07D471/04 , C07D413/12 , C07D403/12 , C07D417/12 , C07D401/04 , C07D401/14 , C07D409/12 , C07D409/14 , A61P1/14 , A61P25/00
CPC分类号： C07D409/04 , C07D231/16 , C07D231/56 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14
摘要： The present invention relates to the orexin receptor antagonists compounds of the general formula (I) as well as to their isomers, salts and solvates, to the pharmaceutical compositions containing them and to the therapeutic application thereof.
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公开(公告)号：EP1940777A1
公开(公告)日：2008-07-09
申请号：EP06795037.8
申请日：2006-09-19
申请人： Sanofi-Aventis
发明人： PAPPNÉ BEHR, Ágnes , KAPUI, Zoltán , ARÁNYI, Péter , BÁTORI, Sándor , BARTÁNÉ BODOR, Veronika , VARGA, Márton , MIKUS, Endre , URBÁN-SZABÓ, Katalin , VARGÁNÉ SZEREDI, Judit , SZABÓ, Tibor , SUSÁN, Edit , KOVÁCS, Marianna , T. NAGY, Lajos
IPC分类号： C07C233/40 , A61K31/165 , A61P37/00
CPC分类号： C07C233/36 , C07D263/58 , C07D277/68 , C07D277/82
摘要： The present invention relates to the CCR3 receptor ligands of the general formula (I), within them favourably to antagonists and to the salts, solvates and isomers thereof, to the pharmaceutical compositions containing them, to the use of the compounds of the general formula (I) and their salts, solvates and isomers and to the preparation of the compounds of the general formula (I) and their salts, solvates and isomers and to the new intermediates of the general formula (XX) and (XXI).
摘要翻译： 本发明涉及通式（I）的CCR3受体配体，在其中有利地涉及拮抗剂及其盐，溶剂化物和异构体，含有它们的药物组合物，涉及通式 I）化合物及其盐，溶剂化物和异构体以及制备通式（I）化合物及其盐，溶剂化物和异构体以及通式（XX）和（XXI）的新中间体。
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公开(公告)号：EP1940776A2
公开(公告)日：2008-07-09
申请号：EP06795038.6
申请日：2006-09-21
申请人： Sanofi-Aventis
发明人： PAPPNÉ BEHR, Ágnes , KAPUI, Zoltán , ARÁNYI, Péter , BÁTORI, Sándor , BARTÁNÉ BODOR, Veronika , VARGA, Márton , MIKUS, Endre , URBÁN-SZABÓ, Katalin , VARGÁNE SZEREDI, Judit , SZABÓ, Tibor , SUSÁN, Edit , KOVÁCS, Marianna , T. NAGY, Lajos
IPC分类号： C07C233/35 , C07C323/63 , A61K31/4965
CPC分类号： C07C233/78 , C07C233/40 , C07D235/28 , C07D263/58
摘要： The present invention relates to the CCR3 receptor ligands of the general formula (I), within them favourably to antagonists and to the salts, solvates and isomers thereof, to the pharmaceutical compositions containing them, to the use of the compounds of the general formula (I) and their salts, solvates and isomers and to the preparation of the compounds of the general formula (I) and their salts, solvates and isomers.
摘要翻译： 本发明涉及通式（I）的CCR3受体配体，在其中有利地涉及拮抗剂及其盐，溶剂化物和异构体，含有它们的药物组合物，涉及通式 I）及其盐，溶剂合物和异构体，以及制备通式（I）化合物及其盐，溶剂合物和异构体。
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