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公开(公告)号：EP1663982A1
公开(公告)日：2006-06-07
申请号：EP04769079.7
申请日：2004-07-23
申请人： Sanofi-Aventis
发明人： ARANYI, Péter , BATORI, Sándor , TIMARI , Géza , BOER, Kinga , KAPUI, Zoltán , MIKUS, Endre , URBAN-SZABO , Katalin , GERBER, Katalin , VARGANE SZEREDI, Judit , FINET, Michel
IPC分类号： C07D215/54 , C07D405/12 , C07D409/12 , C07D265/26 , C07C229/60 , A61K31/47 , A61P11/00
CPC分类号： C07D405/12 , C07C229/50 , C07D215/48 , C07D405/14 , C07D409/12 , C07D409/14 , C07D491/04
摘要： Compounds of the general formula (I), and their salts, solvates, isomers (tautomers, desmotrops, optically active isomers) as well as the salts and solvates; are strong adenosine A3 receptor ligands preferably antagonists.
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公开(公告)号：EP1487807A2
公开(公告)日：2004-12-22
申请号：EP03743452.9
申请日：2003-03-04
申请人： Sanofi-Aventis
发明人： ARANYI, Péter , BALAZS, Lászlo , BATA, Imre , BATORI, Sándor , BORONKAY, Eva , BOVY, Philippe , KANAI, Károly , KAPUI, Zoltán , SUSAN, Edit , SZABO, Tibor , NAGY, Lajos, T. , URBAN-SZABO, Katalin , VARGA, Márton
IPC分类号： C07D241/04 , C07D451/14 , C07D401/14 , C07D417/14 , C07D413/14 , C07D207/16 , C07D401/04 , C07D417/04 , C07D413/04 , C07D405/04 , C07D211/58
CPC分类号： C07D451/04 , C07D207/16 , C07D211/58 , C07D401/04 , C07D401/14 , C07D405/06 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D451/14
摘要： The present invention relates to new, potent DPP-IV enzyme inhibitors of the general formula (I), which contain fluorine atoms.
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公开(公告)号：EP1663982B1
公开(公告)日：2007-11-21
申请号：EP04769079.7
申请日：2004-07-23
申请人： Sanofi-Aventis
发明人： ARANYI, Péter , BATORI, Sándor , TIMARI , Géza , BOER, Kinga , KAPUI, Zoltán , MIKUS, Endre , URBAN-SZABO , Katalin , GERBER, Katalin , VARGANE SZEREDI, Judit , FINET, Michel
IPC分类号： C07D215/54 , C07D405/12 , C07D409/12 , C07D265/26 , C07C229/60 , A61K31/47 , A61P11/00
CPC分类号： C07D405/12 , C07C229/50 , C07D215/48 , C07D405/14 , C07D409/12 , C07D409/14 , C07D491/04
摘要： Compounds of the general formula (I), and their salts, solvates, isomers (tautomers, desmotrops, optically active isomers) as well as the salts and solvates; are strong adenosine A3 receptor ligands preferably antagonists.
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4.发明授权AZABICYCLO-OCTANE AND NONANE DERIVATIVES WITH DDP-IV INHIBITING ACTIVITY 有权WITH DDP-IV抑制作用氮杂双环辛烷和壬烷衍生物
公开(公告)号：EP1517907B1
公开(公告)日：2011-01-12
申请号：EP03738355.1
申请日：2003-06-11
申请人： Sanofi-Aventis
发明人： ARANYI, Péter , BALAZS, Lászlo , BATA, Imre , BATORI, Sándor , BORONKAY, Eva , KAPUI, Zoltán , SUSAN, Edit , SZABO, Tibor , T. NAGY, Lajos , URBAN-SZABO, Katalin , VARGA, Márton
IPC分类号： C07D277/06 , C07D207/06 , C07D207/16 , C07D263/04 , C07D263/06
CPC分类号： C07D451/04 , C07D207/06 , C07D207/16 , C07D263/06 , C07D277/06 , C07D451/14
摘要： The present invention relates to the novel compounds of the general formula (I) possessing DPP-IV inhibitory activity. These compounds contain tropane building blocks.
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公开(公告)号：EP1487807B1
公开(公告)日：2009-09-16
申请号：EP03743452.9
申请日：2003-03-04
申请人： Sanofi-Aventis
发明人： ARANYI, Péter , BALAZS, Lászlo , BATA, Imre , BATORI, Sándor , BORONKAY, Eva , BOVY, Philippe , KANAI, Károly , KAPUI, Zoltán , SUSAN, Edit , SZABO, Tibor , NAGY, Lajos, T. , URBAN-SZABO, Katalin , VARGA, Márton
IPC分类号： C07D241/04 , C07D451/14 , C07D401/14 , C07D417/14 , C07D413/14 , C07D207/16 , C07D401/04 , C07D417/04 , C07D413/04 , C07D405/04 , C07D211/58
CPC分类号： C07D451/04 , C07D207/16 , C07D211/58 , C07D401/04 , C07D401/14 , C07D405/06 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D451/14
摘要： The present invention relates to new, potent DPP-IV enzyme inhibitors of the general formula (I), which contain fluorine atoms.
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公开(公告)号：EP1718632B1
公开(公告)日：2009-04-22
申请号：EP05708501.1
申请日：2005-02-08
申请人： Sanofi-Aventis
发明人： ARANYI, Péter , BALOGH, Mária , BATORI, Sándor , BENCE, Judit , FINET, Michel , KAPUI, Zoltán , PHILIPPO, Christophe , SZAB , Tibor , SZLAVIK, Zoltán , TÖMÖSKÖZI, Zsuzsanna , URBAN-SZABO , Katalin , VENIER, Olivier
IPC分类号： C07D401/04 , C07D401/06 , C07D239/42 , C07D401/12 , C07D401/14 , C07D409/04 , C07D409/12 , C07D409/14 , C07D407/04 , C07D407/12 , C07D413/06 , A61K31/505 , A61K31/506 , A61K31/5377 , A61P3/00
CPC分类号： C07D401/14 , C07D239/42 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/06
摘要： The present invention relates to the orexin receptor antagonists of the general formula (I), which are selective to orexin I receptors. (I) -wherein Ar stands for phenyl group or a 5- or 6-membered heterocyclic ring containing 1-3 identical or different heteroatoms or methylenedioxyphenyl group -these groups may optionally be substituted with one or more identical or different C1.4 alkyl group, halogen atom, hydroxyl group, C1-4 alkoxy group, trihalogenomethyl group, NHC1.4 alkyl, -N(CI-4 alkyl)2 or -NHC(=0)-C1-4 alkyl group,
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7.发明公开AZABICYCLO-OCTANE AND NONANE DERIVATIVES WITH DDP-IV INHIBITING ACTIVITY 有权WITH DDP-IV抑制作用氮杂双环辛烷和壬烷衍生物
公开(公告)号：EP1517907A2
公开(公告)日：2005-03-30
申请号：EP03738355.1
申请日：2003-06-11
申请人： Sanofi-Aventis
发明人： ARANYI, Péter , BALAZS, Lászlo , BATA, Imre , BATORI, Sándor , BORONKAY, Eva , KAPUI, Zoltán , SUSAN, Edit , SZABO, Tibor , T. NAGY, Lajos , URBAN-SZABO, Katalin , VARGA, Márton
IPC分类号： C07D451/04 , C07D451/14 , A61K31/46 , A61P3/10 , C07D277/06 , C07D207/06 , C07D207/16 , C07D263/04 , C07D263/06
CPC分类号： C07D451/04 , C07D207/06 , C07D207/16 , C07D263/06 , C07D277/06 , C07D451/14
摘要： The present invention relates to the novel compounds of the general formula (I) possessing DPP-IV inhibitory activity. These compounds contain tropane building blocks.
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公开(公告)号：EP1718632A1
公开(公告)日：2006-11-08
申请号：EP05708501.1
申请日：2005-02-08
申请人： Sanofi-Aventis
发明人： ARANYI, Péter , BALOGH, Mária , BATORI, Sándor , BENCE, Judit , FINET, Michel , KAPUI, Zoltán , PHILIPPO, Christophe , SZAB , Tibor , SZLAVIK, Zoltán , TÖMÖSKÖZI, Zsuzsanna , URBAN-SZABO , Katalin , VENIER, Olivier
IPC分类号： C07D401/04 , C07D401/06 , C07D239/42 , C07D401/12 , C07D401/14 , C07D409/04 , C07D409/12 , C07D409/14 , C07D407/04 , C07D407/12 , C07D413/06 , A61K31/505 , A61K31/506 , A61K31/5377 , A61P3/00
CPC分类号： C07D401/14 , C07D239/42 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/06
摘要： The present invention relates to the orexin receptor antagonists of the general formula (I), which are selective to orexin I receptors. (I) -wherein Ar stands for phenyl group or a 5- or 6-membered heterocyclic ring containing 1-3 identical or different heteroatoms or methylenedioxyphenyl group -these groups may optionally be substituted with one or more identical or different C1.4 alkyl group, halogen atom, hydroxyl group, C1-4 alkoxy group, trihalogenomethyl group, NHC1.4 alkyl, -N(CI-4 alkyl)2 or -NHC(=0)-C1-4 alkyl group,
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