公开(公告)号：EP1718632B1

公开(公告)日：2009-04-22

申请号：EP05708501.1

申请日：2005-02-08

申请人： Sanofi-Aventis

发明人： ARANYI, Péter ,  BALOGH, Mária ,  BATORI, Sándor ,  BENCE, Judit ,  FINET, Michel ,  KAPUI, Zoltán ,  PHILIPPO, Christophe ,  SZAB , Tibor ,  SZLAVIK, Zoltán ,  TÖMÖSKÖZI, Zsuzsanna ,  URBAN-SZABO , Katalin ,  VENIER, Olivier

IPC分类号： C07D401/04 ,  C07D401/06 ,  C07D239/42 ,  C07D401/12 ,  C07D401/14 ,  C07D409/04 ,  C07D409/12 ,  C07D409/14 ,  C07D407/04 ,  C07D407/12 ,  C07D413/06 ,  A61K31/505 ,  A61K31/506 ,  A61K31/5377 ,  A61P3/00

CPC分类号： C07D401/14 ,  C07D239/42 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D405/04 ,  C07D405/12 ,  C07D409/04 ,  C07D409/12 ,  C07D409/14 ,  C07D413/06

摘要： The present invention relates to the orexin receptor antagonists of the general formula (I), which are selective to orexin I receptors. (I) -wherein Ar stands for phenyl group or a 5- or 6-membered heterocyclic ring containing 1-3 identical or different heteroatoms or methylenedioxyphenyl group -these groups may optionally be substituted with one or more identical or different C1.4 alkyl group, halogen atom, hydroxyl group, C1-4 alkoxy group, trihalogenomethyl group, NHC1.4 alkyl, -N(CI-4 alkyl)2 or -NHC(=0)-C1-4 alkyl group,

公开(公告)号：EP1718632A1

公开(公告)日：2006-11-08

申请号：EP05708501.1

申请日：2005-02-08

申请人： Sanofi-Aventis

发明人： ARANYI, Péter ,  BALOGH, Mária ,  BATORI, Sándor ,  BENCE, Judit ,  FINET, Michel ,  KAPUI, Zoltán ,  PHILIPPO, Christophe ,  SZAB , Tibor ,  SZLAVIK, Zoltán ,  TÖMÖSKÖZI, Zsuzsanna ,  URBAN-SZABO , Katalin ,  VENIER, Olivier

IPC分类号： C07D401/04 ,  C07D401/06 ,  C07D239/42 ,  C07D401/12 ,  C07D401/14 ,  C07D409/04 ,  C07D409/12 ,  C07D409/14 ,  C07D407/04 ,  C07D407/12 ,  C07D413/06 ,  A61K31/505 ,  A61K31/506 ,  A61K31/5377 ,  A61P3/00

CPC分类号： C07D401/14 ,  C07D239/42 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D405/04 ,  C07D405/12 ,  C07D409/04 ,  C07D409/12 ,  C07D409/14 ,  C07D413/06

摘要： The present invention relates to the orexin receptor antagonists of the general formula (I), which are selective to orexin I receptors. (I) -wherein Ar stands for phenyl group or a 5- or 6-membered heterocyclic ring containing 1-3 identical or different heteroatoms or methylenedioxyphenyl group -these groups may optionally be substituted with one or more identical or different C1.4 alkyl group, halogen atom, hydroxyl group, C1-4 alkoxy group, trihalogenomethyl group, NHC1.4 alkyl, -N(CI-4 alkyl)2 or -NHC(=0)-C1-4 alkyl group,