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公开(公告)号：EP2167470B1
公开(公告)日：2011-03-16
申请号：EP08762666.9
申请日：2008-06-02
申请人： Sanofi-Aventis
发明人： SUSÁN, Edit , BOÉR, Kinga , KAPUI, Zoltán , TIMÁRI, Géza , BÁTORI, Sándor , SZLÁVIK, Zoltán , MIKUS, Endre , VARGÁNÉ SZEREDI, Judit , FINET, Michel , URBÁN SZABÓ, Katalin , SZABÓ, Tibor
IPC分类号： C07D215/58 , C07D471/04 , C07F7/22 , A61K31/4745 , A61P11/06 , A61P29/00
CPC分类号： C07D471/04
摘要： The present invention relates to the adenosine A3 receptor ligands of the general formula (I), within them favourably to the antagonists, to their salts, solvates,
N -oxides and isomers, to the pharmaceutical compositions containing the compounds of the general formula (I), their salts, solvates,
N -oxides and isomers, to the use of the compounds of the general formula (I), their salts, solvates,
N -oxides and isomers, to the preparation of the compounds of the general formula (I), their salts, solvates,
N -oxides and isomers, as well as to the new intermediates of the general formula (II), (VI), (XI), (XII) and (XV), and to the preparation thereof.-
公开(公告)号：EP2167470A1
公开(公告)日：2010-03-31
申请号：EP08762666.9
申请日：2008-06-02
申请人： Sanofi-Aventis
发明人： SUSÁN, Edit , BOÉR, Kinga , KAPUI, Zoltán , TÍMÁRI, Géza , BÁTORI, Sándor , SZLÁVIK, Zoltán , MIKUS, Endre , VARGÁNÉ SZEREDI, Judit , FINET, Michel , URBÁN SZABÓ, Katalin , SZABÓ, Tibor
IPC分类号： C07D215/58 , C07D471/04 , C07F7/22 , A61K31/4745 , A61P11/06 , A61P29/00
CPC分类号： C07D471/04
摘要： The present invention relates to the adenosine A3 receptor ligands of the general formula (I), within them favourably to the antagonists, to their salts, solvates,
N -oxides and isomers, to the pharmaceutical compositions containing the compounds of the general formula (I), their salts, solvates,
N -oxides and isomers, to the use of the compounds of the general formula (I), their salts, solvates,
N -oxides and isomers, to the preparation of the compounds of the general formula (I), their salts, solvates,
N -oxides and isomers, as well as to the new intermediates of the general formula (II), (VI), (XI), (XII) and (XV), and to the preparation thereof.-
公开(公告)号：EP1663982B1
公开(公告)日：2007-11-21
申请号：EP04769079.7
申请日：2004-07-23
申请人： Sanofi-Aventis
发明人： ARANYI, Péter , BATORI, Sándor , TIMARI , Géza , BOER, Kinga , KAPUI, Zoltán , MIKUS, Endre , URBAN-SZABO , Katalin , GERBER, Katalin , VARGANE SZEREDI, Judit , FINET, Michel
IPC分类号： C07D215/54 , C07D405/12 , C07D409/12 , C07D265/26 , C07C229/60 , A61K31/47 , A61P11/00
CPC分类号： C07D405/12 , C07C229/50 , C07D215/48 , C07D405/14 , C07D409/12 , C07D409/14 , C07D491/04
摘要： Compounds of the general formula (I), and their salts, solvates, isomers (tautomers, desmotrops, optically active isomers) as well as the salts and solvates; are strong adenosine A3 receptor ligands preferably antagonists.
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公开(公告)号：EP1718632B1
公开(公告)日：2009-04-22
申请号：EP05708501.1
申请日：2005-02-08
申请人： Sanofi-Aventis
发明人： ARANYI, Péter , BALOGH, Mária , BATORI, Sándor , BENCE, Judit , FINET, Michel , KAPUI, Zoltán , PHILIPPO, Christophe , SZAB , Tibor , SZLAVIK, Zoltán , TÖMÖSKÖZI, Zsuzsanna , URBAN-SZABO , Katalin , VENIER, Olivier
IPC分类号： C07D401/04 , C07D401/06 , C07D239/42 , C07D401/12 , C07D401/14 , C07D409/04 , C07D409/12 , C07D409/14 , C07D407/04 , C07D407/12 , C07D413/06 , A61K31/505 , A61K31/506 , A61K31/5377 , A61P3/00
CPC分类号： C07D401/14 , C07D239/42 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/06
摘要： The present invention relates to the orexin receptor antagonists of the general formula (I), which are selective to orexin I receptors. (I) -wherein Ar stands for phenyl group or a 5- or 6-membered heterocyclic ring containing 1-3 identical or different heteroatoms or methylenedioxyphenyl group -these groups may optionally be substituted with one or more identical or different C1.4 alkyl group, halogen atom, hydroxyl group, C1-4 alkoxy group, trihalogenomethyl group, NHC1.4 alkyl, -N(CI-4 alkyl)2 or -NHC(=0)-C1-4 alkyl group,
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公开(公告)号：EP1663982A1
公开(公告)日：2006-06-07
申请号：EP04769079.7
申请日：2004-07-23
申请人： Sanofi-Aventis
发明人： ARANYI, Péter , BATORI, Sándor , TIMARI , Géza , BOER, Kinga , KAPUI, Zoltán , MIKUS, Endre , URBAN-SZABO , Katalin , GERBER, Katalin , VARGANE SZEREDI, Judit , FINET, Michel
IPC分类号： C07D215/54 , C07D405/12 , C07D409/12 , C07D265/26 , C07C229/60 , A61K31/47 , A61P11/00
CPC分类号： C07D405/12 , C07C229/50 , C07D215/48 , C07D405/14 , C07D409/12 , C07D409/14 , C07D491/04
摘要： Compounds of the general formula (I), and their salts, solvates, isomers (tautomers, desmotrops, optically active isomers) as well as the salts and solvates; are strong adenosine A3 receptor ligands preferably antagonists.
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公开(公告)号：EP1718632A1
公开(公告)日：2006-11-08
申请号：EP05708501.1
申请日：2005-02-08
申请人： Sanofi-Aventis
发明人： ARANYI, Péter , BALOGH, Mária , BATORI, Sándor , BENCE, Judit , FINET, Michel , KAPUI, Zoltán , PHILIPPO, Christophe , SZAB , Tibor , SZLAVIK, Zoltán , TÖMÖSKÖZI, Zsuzsanna , URBAN-SZABO , Katalin , VENIER, Olivier
IPC分类号： C07D401/04 , C07D401/06 , C07D239/42 , C07D401/12 , C07D401/14 , C07D409/04 , C07D409/12 , C07D409/14 , C07D407/04 , C07D407/12 , C07D413/06 , A61K31/505 , A61K31/506 , A61K31/5377 , A61P3/00
CPC分类号： C07D401/14 , C07D239/42 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/06
摘要： The present invention relates to the orexin receptor antagonists of the general formula (I), which are selective to orexin I receptors. (I) -wherein Ar stands for phenyl group or a 5- or 6-membered heterocyclic ring containing 1-3 identical or different heteroatoms or methylenedioxyphenyl group -these groups may optionally be substituted with one or more identical or different C1.4 alkyl group, halogen atom, hydroxyl group, C1-4 alkoxy group, trihalogenomethyl group, NHC1.4 alkyl, -N(CI-4 alkyl)2 or -NHC(=0)-C1-4 alkyl group,
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