公开(公告)号：EP0259160A2

公开(公告)日：1988-03-09

申请号：EP87307781.2

申请日：1987-09-03

申请人： Schering Biotech Corporation

发明人： Zurawski, Gerard ,  Zurawski, Sandra Marvo

IPC分类号： C12N15/00 ,  C12P21/02 ,  C07H21/04

CPC分类号： C07K14/545

摘要： Synthetic human interleukin-1α genes are provided whose codons are selected from those preferred by bacteria. High expression levels are obtained in an E. coli expression system for both native interleukin-1α and several mutant interleukin-1α's.

摘要翻译： 提供合成人白细胞介素-1α基因，其密码子选自细菌优选的那些。 在用于天然白细胞介素-1α和几种突变白细胞介素-1α的大肠杆菌表达系统中获得高表达水平。

公开(公告)号：EP0481536A1

公开(公告)日：1992-04-22

申请号：EP91122275.0

申请日：1987-09-03

申请人： Schering Biotech Corporation

发明人： Zurawski, Gerard ,  Zurawski, Sandra Marvo

IPC分类号： C12N15/25 ,  C12P21/02 ,  C07K13/00

CPC分类号： C07K14/545

摘要： Synthetic human interleukin-1α genes are provided whose codons are selected from those preferred by bacteria. High expression levels are obtained in an E. coli expression system for both native interleukin-1α and several mutant interleukin-1α's.

摘要翻译： 提供合成人白细胞介素-1α基因，其密码子选自细菌优选的那些。 在用于天然白细胞介素-1α和几种突变白细胞介素-1α的大肠杆菌表达系统中获得高表达水平。

公开(公告)号：EP0259160A3

公开(公告)日：1988-11-30

申请号：EP87307781

申请日：1987-09-03

申请人： Schering Biotech Corporation

发明人： Zurawski, Gerard ,  Zurawski, Sandra Marvo

IPC分类号： C12N15/00 ,  C12P21/02 ,  C07H21/04

CPC分类号： C07K14/545

摘要： Synthetic human interleukin-1α genes are provided whose codons are selected from those preferred by bacteria. High expression levels are obtained in an E. coli expression system for both native interleukin-1α and several mutant interleukin-1α's.