-
公开(公告)号：EP1966151A1
公开(公告)日：2008-09-10
申请号：EP06845064.2
申请日：2006-12-11
申请人： Schering Corporation
发明人： COOPER, Alan , DENG, Yongqi , SHIPPS, Gerald, W., Jr. , SHIH, Neng-yang , ZHU, Hugh , SUN, Robert , KELLY, Joseph , DOLL, Ronald , NAN, Yang , WANG, Tong , DESAI, Jagdish , WANG, James , DONG, Youhao , MADISON, Vincent, S. , XIAO, Li , HRUZA, Alan , SIDDIQUI, M., Arshad , SAMATAR, Ahmed , PALIWAL, Sunil , TSUI, Hon-Chung , CELEBI, Azim, A. , WU, Yiji , BOGA, Sobhana, Babu
IPC分类号： C07D231/56 , C07D403/12 , C07D409/12 , C07D413/12 , C07D417/12 , A61K31/506 , A61K31/427 , A61K31/428 , A61K31/496 , A61P35/00 , C07D417/14 , C07D403/14
CPC分类号： C07D405/14 , C07D231/56 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/14
摘要： Disclosed are the ERK inhibitors of formula 1.0 and the pharmaceutically acceptable salts and solvates thereof. Q is a piperidine or piperazine ring that can have a bridge or a fused ring. The piperidine ring can have a double bond in the ring. All other substitutents are as defined herein. Also disclosed are methods of treating cancer using the compounds of formula 1.0.
-
公开(公告)号：EP1984331B1
公开(公告)日：2010-10-20
申请号：EP07750497.5
申请日：2007-02-13
申请人： Schering Corporation
发明人： DENG, Yongqi , SHIPPS, Gerald, W., Jr. , COOPER, Alan , NAN, Yang , WANG, Tong , SIDDIQUI, M., Arshad , ZHU, Hugh , SUN, Robert , KELLY, Joseph , DOLL, Ronald , DESAI, Jagdish , WANG, James , DONG, Youhao , MADISON, Vincent, S. , XIAO, Li , HRUZA, Alan , SHIH, Neng-yang
IPC分类号： C07D207/16 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D487/08 , A61K31/4025 , A61P35/00
CPC分类号： C07D207/16 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D487/08
摘要： Disclosed are the ERK inhibitors of Formula (1.0): and the pharmaceutically acceptable salts and solvates thereof. Q is a piperidine or piperazine ring that can have a bridge or a fused ring. The piperidine ring can have a double bond in the ring. All other substitutents are as defined herein. Also disclosed are methods of treating cancer using the compounds of Formula (1.0).
-
3.发明公开POLYCYCLIC INDAZOLE DERIVATIVES AND THEIR USE AS ERK INHIBITORS FOR THE TREATMENT OF CANCER 有权多环的吲唑衍生物及其作为ERK抑制剂用于治疗癌症的用途
公开(公告)号：EP2155722A1
公开(公告)日：2010-02-24
申请号：EP08768067.4
申请日：2008-06-04
申请人： Schering Corporation
发明人： COOPER, Alan , DENG, Yongqi , SHIPPS, Gerald, W., Jr. , SHIH, Neng-Yang , ZHU, Hugh , KELLY, Joseph , DOLL, Ronald , NAN, Yang , DESAI, Jagdish , WANG, James , PALIWAL, Sunil , TSUI, Hon-Chung , BOGA, Sobhana, Babu , ALHASSAN, Abdul-Basit , GAO, Xiaolei , ZHU, Liang , PATEL, Mehul
IPC分类号： C07D401/14 , C07D403/14 , C07D407/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D491/056 , A61K31/4245 , A61K31/444 , A61K31/506 , A61P35/00
CPC分类号： C07D401/14 , C07D403/14 , C07D407/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D491/056
摘要： Disclosed are the ERK inhibitors of formula 1.0: (Chemical formula should be inserted here as it appears on abstract in paper form) and the pharmaceutically acceptable salts, esters and solvates thereof. Q is a piperidine or piperazine ring that can have a bridge or a fused ring. The piperidine ring can have a double bond in the ring. All other substitutents are as defined herein. Also disclosed are methods of treating cancer using the compounds of formula 1.0.
-
4.发明授权
公开(公告)号：EP1313725B1
公开(公告)日：2007-04-11
申请号：EP01968188.1
申请日：2001-08-28
发明人： NJOROGE, F., George , VIBULBHAN, Bancha , COOPER, Alan, B. , GUZI, Timothy , RANE, Dinanath, F. , MINOR, Keith, P. , DOLL, Ronald, J. , GIRIJAVALLABHAN, Viyyoor, Moopil , SANTHANAM, Bama , PINTO, Patrick, A. , ZHU, Hugh, Y. , KEERTIKAR, Kartik, M. , ALVAREZ, Carmen, S. , BALDWIN, John, J. , LI, Ge , HUANG, Chia-Yu , JAMES, Ray, A. , BISHOP, Robert, W. , WANG, James , DESAI, Jagdish, A.
IPC分类号： C07D401/06 , C07D401/04 , C07D401/14 , C07D221/16 , A61K31/435 , A61P35/00
CPC分类号： C07D231/12 , C07D221/16 , C07D233/56 , C07D249/08 , C07D401/04 , C07D401/06 , C07D401/14
摘要： The present invention discloses novel tricyclic compounds represented by the formula (1.0), a prodrug thereof, or a pharmaceutically acceptable salt or solvate of the compound or of said prodrug useful for inhibiting farnesyl protein transferase. Also disclosed are pharmaceutical compositions comprising such compounds their preparation as well as methods of using them to treat proliferative diseases such as cancer.
-
公开(公告)号：EP1966151B1
公开(公告)日：2011-10-05
申请号：EP06845064.2
申请日：2006-12-11
申请人： Schering Corporation
发明人： COOPER, Alan , DENG, Yongqi , SHIPPS, Gerald, W., Jr. , SHIH, Neng-yang , ZHU, Hugh , SUN, Robert , KELLY, Joseph , DOLL, Ronald , NAN, Yang , WANG, Tong , DESAI, Jagdish , WANG, James , DONG, Youhao , MADISON, Vincent, S. , XIAO, Li , HRUZA, Alan , SIDDIQUI, M., Arshad , SAMATAR, Ahmed , PALIWAL, Sunil , TSUI, Hon-Chung , CELEBI, Azim, A. , WU, Yiji , BOGA, Sobhana, Babu
IPC分类号： C07D231/56 , C07D403/12 , C07D409/12 , C07D413/12 , C07D417/12 , A61K31/506 , A61K31/427 , A61K31/428 , A61K31/496 , A61P35/00 , C07D417/14 , C07D403/14
CPC分类号： C07D405/14 , C07D231/56 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/14
摘要： Disclosed are the ERK inhibitors of formula 1.0 and the pharmaceutically acceptable salts and solvates thereof. Q is a piperidine or piperazine ring that can have a bridge or a fused ring. The piperidine ring can have a double bond in the ring. All other substitutents are as defined herein. Also disclosed are methods of treating cancer using the compounds of formula 1.0.
-
公开(公告)号：EP1984331A1
公开(公告)日：2008-10-29
申请号：EP07750497.5
申请日：2007-02-13
申请人： Schering Corporation
发明人： DENG, Yongqi , SHIPPS, Gerald, W., Jr. , COOPER, Alan , NAN, Yang , WANG, Tong , SIDDIQUI, M., Arshad , ZHU, Hugh , SUN, Robert , KELLY, Joseph , DOLL, Ronald , DESAI, Jagdish , WANG, James , DONG, Youhao , MADISON, Vincent, S. , XIAO, Li , HRUZA, Alan , SHIH, Neng-yang
IPC分类号： C07D207/16 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D487/08 , A61K31/4025 , A61P35/00
CPC分类号： C07D207/16 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D487/08
摘要： Disclosed are the ERK inhibitors of Formula (1.0): and the pharmaceutically acceptable salts and solvates thereof. Q is a piperidine or piperazine ring that can have a bridge or a fused ring. The piperidine ring can have a double bond in the ring. All other substitutents are as defined herein. Also disclosed are methods of treating cancer using the compounds of Formula (1.0).
-
7.发明公开
公开(公告)号：EP1313725A1
公开(公告)日：2003-05-28
申请号：EP01968188.1
申请日：2001-08-28
发明人： NJOROGE, F., George , VIBULBHAN, Bancha , COOPER, Alan, B. , GUZI, Timothy , RANE, Dinanath, F. , MINOR, Keith, P. , DOLL, Ronald, J. , GIRIJAVALLABHAN, Viyyoor, Moopil , SANTHANAM, Bama , PINTO, Patrick, A. , ZHU, Hugh, Y. , KEERTIKAR, Kartik, M. , ALVAREZ, Carmen, S. , BALDWIN, John, J. , LI, Ge , HUANG, Chia-Yu , JAMES, Ray, A. , BISHOP, Robert, W. , WANG, James , DESAI, Jagdish, A.
IPC分类号： C07D401/06 , C07D401/04 , C07D401/14 , C07D221/16 , A61K31/435 , A61P35/00
CPC分类号： C07D231/12 , C07D221/16 , C07D233/56 , C07D249/08 , C07D401/04 , C07D401/06 , C07D401/14
摘要： The present invention discloses novel tricyclic compounds represented by the formula (1.0), a prodrug thereof, or a pharmaceutically acceptable salt or solvate of the compound or of said prodrug useful for inhibiting farnesyl protein transferase. Also disclosed are pharmaceutical compositions comprising such compounds their preparation as well as methods of using them to treat proliferative diseases such as cancer.
-
公开(公告)号：EP0760822A1
公开(公告)日：1997-03-12
申请号：EP95918288.0
申请日：1995-05-01
申请人： SCHERING CORPORATION
发明人： COOPER, Alan B. , SAKSENA, Anil , RANE, Dinanath F. , JAO, Edwin , GIRIJAVALLABHAN, Viyyoor M. , GANGULY, Ashit , DESAI, Jagdish A. , WANG, James
摘要： Compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, X1, X2, X3, X4, X5, X6, X7, and X8, as set forth herein are described. These compounds are useful as agents in the treatment of fungal infections.
-
-
-
-
-
-
-
搜索结果
8 条记录 (耗时 0.03 秒)
