公开(公告)号：EP2680873A2

公开(公告)日：2014-01-08

申请号：EP12751994.0

申请日：2012-03-02

申请人： Seachaid Pharmaceuticals, Inc.

发明人： JAMES, Kenneth, Duke, Jr. ,  LAUDEMAN, Christopher, Patrick ,  MALKAR, Navdeep, Balkrishna ,  RADHAKRISHNAN, Balasingham

IPC分类号： A61K38/12

CPC分类号： C07K7/64 ,  A61K38/00 ,  A61K38/04 ,  A61K38/08 ,  A61K38/12 ,  C07K7/00 ,  C07K7/50 ,  C07K7/54 ,  C07K7/56 ,  C07K7/60

摘要： The invention features echinocandin class compounds. The compounds can be useful for the treatment of fungal infections.

公开(公告)号：EP2470190A1

公开(公告)日：2012-07-04

申请号：EP10812617.8

申请日：2010-08-26

申请人： Seachaid Pharmaceuticals, Inc.

发明人： JAMES, Kenneth, Duke ,  LAUDEMAN, Christopher, Patrick

IPC分类号： A61K38/00

CPC分类号： C07K7/56 ,  A61K38/00 ,  A61K47/60

摘要： The invention features echinocandin class compounds that have been modified to (i) have activity against one or more fungal species or genera; (ii) have increased aqueous solubility; (iii) have an increased therapeutic index; (iv) be suitable for topical administration; and/or (v) be suitable for oral administration. The echinocandin class compounds of the invention include, for example, a PEG, alkyl-PEG, aryl-PEG, alkaryl-PEG, PEG-alkyl, PEG-aryl, or PEG-alkaryl substituent.

摘要翻译： 本发明的特征是棘白菌素类化合物已被修饰成（i）具有针对一种或多种真菌物种或属的活性; （ii）具有增加的水溶性; （iii）治疗指数增加; （iv）适合局部给药; 和/或（v）适合口服给药。 本发明的棘白菌素类化合物包括例如PEG，烷基-PEG，芳基-PEG，烷芳基-PEG，PEG-烷基，PEG-芳基或PEG-烷芳基取代基。