公开(公告)号：EP3812384A1

公开(公告)日：2021-04-28

申请号：EP19822932.0

申请日：2019-06-21

申请人： Shanghai Institute of Materia Medica, Chinese Academy of Sciences ,  Suzhou Vigonvita Life Sciences Co., Ltd. ,  Topharman Shanghai Co., Ltd.

发明人： SHEN, Jingshan ,  HE, Yang ,  WANG, Zhen ,  LI, Jianfeng ,  LIU, Yongjian ,  SUO, Jin ,  TIAN, Guanghui ,  CHEN, Weiming ,  YANG, Feipu ,  WANG, Yu ,  JIANG, Xiangrui ,  ZHANG, Rongxia ,  JIANG, Hualiang

IPC分类号： C07D409/14 ,  C07D409/12

摘要： The present invention relates to a maleate salt of a benzothiophene compound, a crystalline form and use thereof. Specifically, the present invention relates to a compound of formula (I-A), a crystalline form A, a preparation method thereof and a pharmaceutical composition comprising the same, and a use thereof in the preparation of drugs for preventing or treating the central nervous system diseases. The compound of formula (I-A) and the crystalline form A thereof in the present invention have excellent physical and chemical properties, high oral bioavailability, and the best comprehensive properties for preparing into drugs and they are more suitable for making pharmaceutical preparations and more suitable for storage.

公开(公告)号：EP3115361A1

公开(公告)日：2017-01-11

申请号：EP15757771.9

申请日：2015-03-09

申请人： Shanghai Institute Of Materia Medica Chinese Academy of Sciences ,  Suzhou Vigonvita Life Sciences Co., Ltd. ,  Topharman Shandong Co., Ltd.

发明人： JIANG, Hualiang ,  WANG, Zhen ,  LI, Jianfeng ,  ZHANG, Rongxia ,  HE, Yang ,  LIU, Yongjian ,  BI, Minghao ,  LIU, Zheng ,  TIAN, Guanghui ,  CHEN, Weiming ,  YANG, Feipu ,  WU, Chunhui ,  WANG, Yu ,  JIANG, Xiangrui ,  YIN, Jingjing ,  WANG, Guan ,  SHEN, Jingshan

IPC分类号： C07D409/12 ,  C07D471/04 ,  C07D409/14 ,  C07D519/00 ,  C07D495/04 ,  C07D417/12 ,  C07D413/12 ,  A61K31/496 ,  A61K31/519 ,  A61K31/4709 ,  A61K31/517 ,  A61K31/538 ,  A61K31/5415 ,  A61K31/55 ,  A61P25/00 ,  A61P25/18 ,  A61P25/24 ,  A61P25/22

CPC分类号： C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D495/04 ,  C07D519/00

摘要： Provided are heterocyclic compounds represented by formula (I), stereoisomers or pharmaceutically acceptable salts of said compounds, a pharmaceutical composition of said compounds, and an application of said compounds in the preparation of a drug for the prevention and/or treatment of a central nervous system disease.

公开(公告)号：EP3670511A1

公开(公告)日：2020-06-24

申请号：EP18846464.8

申请日：2018-08-14

申请人： Shanghai Institute of Materia Medica, Chinese Academy of Sciences ,  Topharman Shanghai Co., Ltd.

发明人： HE, Yang ,  JIANG, Xiangrui ,  LI, Jianfeng ,  WANG, Yu ,  WANG, Zhen ,  CHEN, Weiming ,  ZHU, Fuqiang ,  WU, Chunhui ,  ZHANG, Rongxia ,  SHEN, Jingshan ,  JIANG, Hualiang

IPC分类号： C07D455/03 ,  A61K31/4375 ,  A61P25/06 ,  A61P25/16 ,  A61P25/18 ,  A61P25/30

摘要： The present invention provides a tetrahydroprotoberberine compound represented by the formula (I), enantiomers, diastereomers, racemates and mixtures thereof, and pharmaceutically acceptable salts, crystalline hydrates and solvates thereof. The invention also provides a method for preparing the compound and the use thereof in the preparation of a medicament for preventing and/or treating central nervous system diseases.

公开(公告)号：EP3650444A1

公开(公告)日：2020-05-13

申请号：EP18827841.0

申请日：2018-07-02

申请人： Shanghai Institute Materia Medica, Chinese Academy Of Sciences ,  Suzhou Vigonvita Life Sciences Co., Ltd. ,  Topharman Shanghai Co., Ltd.

发明人： SHEN, Jingshan ,  HE, Yang ,  CHEN, Weiming ,  LI, Jianfeng ,  TIAN, Guanghui ,  GONG, Xudong ,  WANG, Zhen ,  ZHANG, Rongxia ,  LIU, Yongjian ,  JIANG, Hualiang

IPC分类号： C07D239/32 ,  C07D239/36 ,  A61P15/10 ,  A61K31/506

摘要： The present invention relates to a salt of phenyl pyrimidinone compound, a polymorph thereof and a pharmaceutical composition comprising the same and a use thereof, particularly relates to the hydrochlorate of phenyl pyrimidinone compound of following formula (I-A) and a pharmaceutically acceptable polymorph, solvate, hydrate, co-crystal, anhydrous substance, or amorphous form thereof, a pharmaceutical composition and a pharmaceutical unit dosage comprising the same, the preparing method and use thereof.