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1.发明公开
公开(公告)号：EP3336078A1
公开(公告)日：2018-06-20
申请号：EP17200696.7
申请日：2004-02-09
发明人： Lu, Xian-Ping , Li, Zhibin , Xie, Aihua , Li, Boyu , Ning, Zhiqiang , Shan, Song , Deng, Tuo , Hu, Weiming , Shi, Leming
IPC分类号： C07D213/56 , C07C233/51 , C07C237/42 , A61K31/4406 , A61K31/165 , A61P17/06 , A61P35/00
CPC分类号： C07D213/56 , A61P17/06 , A61P35/00 , C07C233/51 , C07C237/42
摘要： The present invention is related to the preparation and pharmaceutical use of novel benzamide derivatives as defined in the specification of formula (I) as histone deacetylase inhibitors (HDACI), their preparations and the methods of using these compounds or their pharmaceutically acceptable salt in the treatment of cell proliferative diseases, e.g. cancer and psoriasis.
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2.发明公开Histone deacetylase inhibitors of novel benzamide derivatives with potent differentiation and anti-proliferation acivity 有权具有强效分化和抗增殖活性的新型苯甲酰胺衍生物的组蛋白脱乙酰酶抑制剂
公开(公告)号：EP2860174A2
公开(公告)日：2015-04-15
申请号：EP14166931.7
申请日：2004-02-09
发明人： Lu, Xian-Ping , Li, Zhibin , Xie, Aihua , Li, Boyu , Ning, Zhiqiang , Shan, Song , Deng, Tuo , Hu, Weiming
IPC分类号： C07D213/56 , C07C233/51 , C07C237/42 , A61K31/4406 , A61K31/165 , A61P17/06 , A61P35/00
CPC分类号： C07D213/56 , A61P17/06 , A61P35/00 , C07C233/51 , C07C237/42
摘要： The present invention is related to the preparation and pharmaceutical use of novel benzamide derivatives as defined in the specification of formula (I) as histone deacetylase inhibitors (HDACI), their preparations and the methods of using these compounds or their pharmaceutically acceptable salt in the treatment of cell proliferative diseases, e.g. cancer and psoriasis.
摘要翻译： 本发明涉及如式（I）说明书中定义的新型苯甲酰胺衍生物作为组蛋白脱乙酰酶抑制剂（HDACI）的制备和药物用途，其制备方法和在治疗中使用这些化合物或其药学上可接受的盐的方法 的细胞增殖性疾病，例如 癌症和牛皮癣。
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3.发明公开Histone deacetylase inhibitors of novel benzamide derivatives with potent differentiation and anti-proliferation acivity 有权Neue Benzamidderivate als Histondeacetylaseinhibitoren mit potenter Differenzierungs- und Anti-Proliferationsaktivität
公开(公告)号：EP2860174A3
公开(公告)日：2015-07-08
申请号：EP14166931.7
申请日：2004-02-09
发明人： Lu, Xian-Ping , Li, Zhibin , Xie, Aihua , Li, Boyu , Ning, Zhiqiang , Shan, Song , Deng, Tuo , Hu, Weiming
IPC分类号： C07D213/56 , C07C233/51 , C07C237/42 , A61K31/4406 , A61K31/165 , A61P17/06 , A61P35/00
CPC分类号： C07D213/56 , A61P17/06 , A61P35/00 , C07C233/51 , C07C237/42
摘要： The present invention is related to the preparation and pharmaceutical use of novel benzamide derivatives as defined in the specification of formula (I) as histone deacetylase inhibitors (HDACI), their preparations and the methods of using these compounds or their pharmaceutically acceptable salt in the treatment of cell proliferative diseases, e.g. cancer and psoriasis.
摘要翻译： 本发明涉及式（I）的说明书中所定义的新型苯甲酰胺衍生物作为组蛋白脱乙酰酶抑制剂（HDACI）的制备和药物应用，其制备方法以及在治疗中使用这些化合物或其药学上可接受的盐的方法 的细胞增殖性疾病，例如 癌症和牛皮癣。
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4.发明授权Benzamide Derivative as Histone Deacetylase Inhibitor with Potent Differentiation and Anti-Proliferation Activity 有权苯甲酰胺衍生物作为具有有效分化和抗增殖活性的组蛋白脱乙酰酶抑制剂
公开(公告)号：EP2860174B1
公开(公告)日：2017-11-29
申请号：EP14166931.7
申请日：2004-02-09
发明人： Lu, Xian-Ping , Li, Zhibin , Xie, Aihua , Li, Boyu , Ning, Zhiqiang , Shan, Song , Deng, Tuo , Hu, Weiming , Shi, Leming
IPC分类号： C07D213/56 , C07C233/51 , C07C237/42 , A61K31/4406 , A61K31/165 , A61P17/06 , A61P35/00
CPC分类号： C07D213/56 , A61P17/06 , A61P35/00 , C07C233/51 , C07C237/42
摘要： The present invention is related to the preparation and pharmaceutical use of novel benzamide derivatives as defined in the specification of formula (I) as histone deacetylase inhibitors (HDACI), their preparations and the methods of using these compounds or their pharmaceutically acceptable salt in the treatment of cell proliferative diseases, e.g. cancer and psoriasis.
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