公开(公告)号：EP3456721A2

公开(公告)日：2019-03-20

申请号：EP18203589.9

申请日：2011-08-04

申请人： Shionogi & Co., Ltd

发明人： SUMINO, Yukihito ,  OKAMOTO, Kazuya ,  MASUI, Moriyasu ,  YAMADA, Daisuke ,  IKARASHI, Fumiya

IPC分类号： C07D498/14 ,  C07D211/94 ,  C07D213/80 ,  A61K31/5365 ,  A61P31/18 ,  A61P43/00

摘要： A process for preparing a compound represented by formula (Y1) or (Y2) [wherein R x is an optionally substituted carbocyclyl lower alkyl, or the like] or a salt thereof, using a novel process for preparing a pyridone derivative represented by formula (X4) [wherein R 1d is hydrogen, halogen, or the like; R 2d is hydrogen, a lower alkyl optionally substituted with substituent E, or the like; R 4d is a lower alkyl optionally substituted with substituent E, or the like; and R 6d is a lower alkyl group optionally substituted with substituent group E].

[Chemical formula 8]

公开(公告)号：EP3127908A3

公开(公告)日：2017-02-15

申请号：EP16190894.2

申请日：2011-08-04

申请人： SHIONOGI & CO., LTD

发明人： SUMINO, Yukihito ,  OKAMOTO, Kazuya ,  MASUI, Moriyasu ,  YAMADA, Daisuke ,  IKARASHI, Fumiya

IPC分类号： C07D498/14 ,  A61K31/5365 ,  A61P31/18 ,  A61P43/00 ,  C07D211/94 ,  C07D213/80

CPC分类号： C07D498/14 ,  A61K31/5365 ,  C07B2200/13 ,  C07D213/80

摘要： A process for preparing a compound represented by formula (Y1) or (Y2) [wherein R x is an optionally substituted carbocyclyl lower alkyl, or the like] or a salt thereof, using a novel process for preparing a pyridone derivative represented by formula (X4) [wherein R 1d is hydrogen, halogen, or the like; R 2d is hydrogen, a lower alkyl optionally substituted with substituent E, or the like; R 4d is a lower alkyl optionally substituted with substituent E, or the like; and R 6d is a lower alkyl group optionally substituted with substituent group E].

摘要翻译： 使用由式（Y1）或（Y2）表示的吡啶酮衍生物的新方法制备式（Y1）或（Y2）[其中R x为任选取代的碳环基低级烷基等）或其盐的方法 X4）[其中R 1d是氢，卤素等; R 2d是氢，任选被取代基E取代的低级烷基等; R 4d是任选被取代基E取代的低级烷基等; R 6d为任选被取代基组E取代的低级烷基等）。

公开(公告)号：EP2602260A1

公开(公告)日：2013-06-12

申请号：EP11814690.1

申请日：2011-08-04

申请人： Shionogi & Co., Ltd.

发明人： SUMINO, Yukihito ,  OKAMOTO, Kazuya ,  MASUI, Moriyasu ,  YAMADA, Daisuke ,  IKARASHI, Fumiya

IPC分类号： C07D498/14 ,  A61K31/5365 ,  A61P31/18 ,  A61P43/00 ,  C07D211/94

CPC分类号： C07D498/14 ,  A61K31/5365 ,  C07B2200/13 ,  C07D213/80

摘要： A process for preparing a compound represented by formula (Y1) or (Y2) [wherein R x is an optionally substituted carbocyclyl lower alkyl, or the like] or a salt thereof, using a novel process for preparing a pyridone derivative represented by formula (X4) [wherein R 1d is hydrogen, halogen, or the like; R 2d is hydrogen, a lower alkyl optionally substituted with substituent E, or the like; R 4d is a lower alkyl optionally substituted with substituent E, or the like; and R 6d is a lower alkyl group optionally substituted with substituent group E, or the like].

公开(公告)号：EP3456721A3

公开(公告)日：2019-03-27

申请号：EP18203589.9

申请日：2011-08-04

申请人： Shionogi & Co., Ltd

发明人： SUMINO, Yukihito ,  OKAMOTO, Kazuya ,  MASUI, Moriyasu ,  YAMADA, Daisuke ,  IKARASHI, Fumiya

IPC分类号： C07D498/14 ,  C07D211/94 ,  C07D213/80 ,  A61K31/5365 ,  A61P31/18 ,  A61P43/00

摘要： A process for preparing a compound represented by formula (Y1) or (Y2) [wherein R x is an optionally substituted carbocyclyl lower alkyl, or the like] or a salt thereof, using a novel process for preparing a pyridone derivative represented by formula (X4) [wherein R 1d is hydrogen, halogen, or the like; R 2d is hydrogen, a lower alkyl optionally substituted with substituent E, or the like; R 4d is a lower alkyl optionally substituted with substituent E, or the like; and R 6d is a lower alkyl group optionally substituted with substituent group E].

[Chemical formula 8]

公开(公告)号：EP3127908B1

公开(公告)日：2018-11-28

申请号：EP16190894.2

申请日：2011-08-04

申请人： SHIONOGI & CO., LTD

发明人： SUMINO, Yukihito ,  OKAMOTO, Kazuya ,  MASUI, Moriyasu ,  YAMADA, Daisuke ,  IKARASHI, Fumiya

IPC分类号： C07D498/14

CPC分类号： C07D498/14 ,  A61K31/5365 ,  A61P31/18 ,  A61P43/00 ,  C07B2200/13 ,  C07D211/94 ,  C07D213/80

摘要： A process for preparing a compound represented by formula (Y1) or (Y2) [wherein R x is an optionally substituted carbocyclyl lower alkyl, or the like] or a salt thereof, using a novel process for preparing a pyridone derivative represented by formula (X4) [wherein R 1d is hydrogen, halogen, or the like; R 2d is hydrogen, a lower alkyl optionally substituted with substituent E, or the like; R 4d is a lower alkyl optionally substituted with substituent E, or the like; and R 6d is a lower alkyl group optionally substituted with substituent group E, or the like].

公开(公告)号：EP3150573A1

公开(公告)日：2017-04-05

申请号：EP15799305.6

申请日：2015-05-28

申请人： Shionogi & Co., Ltd.

发明人： TADANO, Genta ,  IKARASHI, Fumiya ,  OKAMOTO, Kazuya ,  MAKI, Toshikatsu ,  HAGIHARA,Motoyuki

IPC分类号： C07C45/49 ,  C07C49/794 ,  C07D239/94 ,  C07D403/12 ,  C07D413/12 ,  C07B61/00

CPC分类号： C07D403/12 ,  C07B61/00 ,  C07B2200/13 ,  C07C45/49 ,  C07C49/794 ,  C07C321/04 ,  C07D239/94 ,  C07D295/03 ,  C07D413/12

摘要： The present invention relates to a Sonogashira-Carbonylation reaction using two types of gas, as well as novel crystals which can control a heat of the said reaction and the process of producing the same. In addition, the present invention relates to a ligand (additive) to prevent the deactivation of a palladium catalyst.

摘要翻译： 本发明涉及使用两种类型的气体的Sonogashira-羰基化反应，以及可控制所述反应的热的新型晶体及其生产方法。 此外，本发明涉及防止钯催化剂失活的配体（添加剂）。

公开(公告)号：EP3127908A2

公开(公告)日：2017-02-08

申请号：EP16190894.2

申请日：2011-08-04

申请人： SHIONOGI & CO., LTD

发明人： SUMINO, Yukihito ,  OKAMOTO, Kazuya ,  MASUI, Moriyasu ,  YAMADA, Daisuke ,  IKARASHI, Fumiya

IPC分类号： C07D498/14 ,  A61K31/5365 ,  A61P31/18 ,  A61P43/00 ,  C07D211/94 ,  C07D213/80

CPC分类号： C07D498/14 ,  A61K31/5365 ,  C07B2200/13 ,  C07D213/80

摘要： A process for preparing a compound represented by formula (Y1) or (Y2) [wherein R x is an optionally substituted carbocyclyl lower alkyl, or the like] or a salt thereof, using a novel process for preparing a pyridone derivative represented by formula (X4) [wherein R 1d is hydrogen, halogen, or the like; R 2d is hydrogen, a lower alkyl optionally substituted with substituent E, or the like; R 4d is a lower alkyl optionally substituted with substituent E, or the like; and R 6d is a lower alkyl group optionally substituted with substituent group E].

摘要翻译： （Y1）或（Y2）[其中Rx为任选取代的碳环基低级烷基等]代表的化合物或其盐的方法，或其盐，采用制备式（X4）代表的吡啶酮衍生物 ）[其中R1d是氢，卤素等; R2d是氢，任选被取代基E取代的低级烷基等; R4d是任选被取代基E取代的低级烷基，等等; 和R6d是任选被取代基E取代的低级烷基]。

公开(公告)号：EP2602260B1

公开(公告)日：2016-09-28

申请号：EP11814690.1

申请日：2011-08-04

申请人： Shionogi & Co., Ltd.

发明人： SUMINO, Yukihito ,  OKAMOTO, Kazuya ,  MASUI, Moriyasu ,  YAMADA, Daisuke ,  IKARASHI, Fumiya

IPC分类号： C07D498/14 ,  C07D211/94 ,  C07D213/80

CPC分类号： C07D498/14 ,  A61K31/5365 ,  C07B2200/13 ,  C07D213/80

摘要： A process for preparing a compound represented by formula (Y1) or (Y2) [wherein R x is an optionally substituted carbocyclyl lower alkyl, or the like] or a salt thereof, using a novel process for preparing a pyridone derivative represented by formula (X4) [wherein R 1d is hydrogen, halogen, or the like; R 2d is hydrogen, a lower alkyl optionally substituted with substituent E, or the like; R 4d is a lower alkyl optionally substituted with substituent E, or the like; and R 6d is a lower alkyl group optionally substituted with substituent group E, or the like].