公开(公告)号：EP3456721A2

公开(公告)日：2019-03-20

申请号：EP18203589.9

申请日：2011-08-04

申请人： Shionogi & Co., Ltd

发明人： SUMINO, Yukihito ,  OKAMOTO, Kazuya ,  MASUI, Moriyasu ,  YAMADA, Daisuke ,  IKARASHI, Fumiya

IPC分类号： C07D498/14 ,  C07D211/94 ,  C07D213/80 ,  A61K31/5365 ,  A61P31/18 ,  A61P43/00

摘要： A process for preparing a compound represented by formula (Y1) or (Y2) [wherein R x is an optionally substituted carbocyclyl lower alkyl, or the like] or a salt thereof, using a novel process for preparing a pyridone derivative represented by formula (X4) [wherein R 1d is hydrogen, halogen, or the like; R 2d is hydrogen, a lower alkyl optionally substituted with substituent E, or the like; R 4d is a lower alkyl optionally substituted with substituent E, or the like; and R 6d is a lower alkyl group optionally substituted with substituent group E].

[Chemical formula 8]

公开(公告)号：EP3127908A3

公开(公告)日：2017-02-15

申请号：EP16190894.2

申请日：2011-08-04

申请人： SHIONOGI & CO., LTD

发明人： SUMINO, Yukihito ,  OKAMOTO, Kazuya ,  MASUI, Moriyasu ,  YAMADA, Daisuke ,  IKARASHI, Fumiya

IPC分类号： C07D498/14 ,  A61K31/5365 ,  A61P31/18 ,  A61P43/00 ,  C07D211/94 ,  C07D213/80

CPC分类号： C07D498/14 ,  A61K31/5365 ,  C07B2200/13 ,  C07D213/80

摘要： A process for preparing a compound represented by formula (Y1) or (Y2) [wherein R x is an optionally substituted carbocyclyl lower alkyl, or the like] or a salt thereof, using a novel process for preparing a pyridone derivative represented by formula (X4) [wherein R 1d is hydrogen, halogen, or the like; R 2d is hydrogen, a lower alkyl optionally substituted with substituent E, or the like; R 4d is a lower alkyl optionally substituted with substituent E, or the like; and R 6d is a lower alkyl group optionally substituted with substituent group E].

摘要翻译： 使用由式（Y1）或（Y2）表示的吡啶酮衍生物的新方法制备式（Y1）或（Y2）[其中R x为任选取代的碳环基低级烷基等）或其盐的方法 X4）[其中R 1d是氢，卤素等; R 2d是氢，任选被取代基E取代的低级烷基等; R 4d是任选被取代基E取代的低级烷基等; R 6d为任选被取代基组E取代的低级烷基等）。

公开(公告)号：EP3109235A1

公开(公告)日：2016-12-28

申请号：EP16164003.2

申请日：2010-03-26

申请人： Shionogi & Co., Ltd

发明人： MASUI, Moriyasu ,  AKIYAMA, Toshiyuki ,  SUMINO, Yukihito ,  OKAMATO, Kazuya

IPC分类号： C07D213/80

CPC分类号： C07D498/14 ,  C07D213/80 ,  C07D309/32 ,  C07D309/40 ,  C07D405/06 ,  C07D471/04 ,  C07D471/14

摘要： Process to make pyridone derivatives.

摘要翻译： 工艺，使吡啶酮衍生物。

公开(公告)号：EP2412709B1

公开(公告)日：2016-05-18

申请号：EP10756205.0

申请日：2010-03-26

申请人： Shionogi & Co., Ltd.

发明人： SUMINO, Yukihito ,  OKAMOTO, Kazuya ,  MASUI, Moriyasu ,  AKIYAMA, Toshiyuki

IPC分类号： C07D213/80 ,  C07D309/32 ,  C07D405/06

CPC分类号： C07D498/14 ,  C07D213/80 ,  C07D309/32 ,  C07D309/40 ,  C07D405/06 ,  C07D471/04 ,  C07D471/14

公开(公告)号：EP2602260A1

公开(公告)日：2013-06-12

申请号：EP11814690.1

申请日：2011-08-04

申请人： Shionogi & Co., Ltd.

发明人： SUMINO, Yukihito ,  OKAMOTO, Kazuya ,  MASUI, Moriyasu ,  YAMADA, Daisuke ,  IKARASHI, Fumiya

IPC分类号： C07D498/14 ,  A61K31/5365 ,  A61P31/18 ,  A61P43/00 ,  C07D211/94

CPC分类号： C07D498/14 ,  A61K31/5365 ,  C07B2200/13 ,  C07D213/80

摘要： A process for preparing a compound represented by formula (Y1) or (Y2) [wherein R x is an optionally substituted carbocyclyl lower alkyl, or the like] or a salt thereof, using a novel process for preparing a pyridone derivative represented by formula (X4) [wherein R 1d is hydrogen, halogen, or the like; R 2d is hydrogen, a lower alkyl optionally substituted with substituent E, or the like; R 4d is a lower alkyl optionally substituted with substituent E, or the like; and R 6d is a lower alkyl group optionally substituted with substituent group E, or the like].

公开(公告)号：EP3127908A2

公开(公告)日：2017-02-08

申请号：EP16190894.2

申请日：2011-08-04

申请人： SHIONOGI & CO., LTD

发明人： SUMINO, Yukihito ,  OKAMOTO, Kazuya ,  MASUI, Moriyasu ,  YAMADA, Daisuke ,  IKARASHI, Fumiya

IPC分类号： C07D498/14 ,  A61K31/5365 ,  A61P31/18 ,  A61P43/00 ,  C07D211/94 ,  C07D213/80

CPC分类号： C07D498/14 ,  A61K31/5365 ,  C07B2200/13 ,  C07D213/80

摘要： A process for preparing a compound represented by formula (Y1) or (Y2) [wherein R x is an optionally substituted carbocyclyl lower alkyl, or the like] or a salt thereof, using a novel process for preparing a pyridone derivative represented by formula (X4) [wherein R 1d is hydrogen, halogen, or the like; R 2d is hydrogen, a lower alkyl optionally substituted with substituent E, or the like; R 4d is a lower alkyl optionally substituted with substituent E, or the like; and R 6d is a lower alkyl group optionally substituted with substituent group E].

摘要翻译： （Y1）或（Y2）[其中Rx为任选取代的碳环基低级烷基等]代表的化合物或其盐的方法，或其盐，采用制备式（X4）代表的吡啶酮衍生物 ）[其中R1d是氢，卤素等; R2d是氢，任选被取代基E取代的低级烷基等; R4d是任选被取代基E取代的低级烷基，等等; 和R6d是任选被取代基E取代的低级烷基]。

公开(公告)号：EP2602260B1

公开(公告)日：2016-09-28

申请号：EP11814690.1

申请日：2011-08-04

申请人： Shionogi & Co., Ltd.

发明人： SUMINO, Yukihito ,  OKAMOTO, Kazuya ,  MASUI, Moriyasu ,  YAMADA, Daisuke ,  IKARASHI, Fumiya

IPC分类号： C07D498/14 ,  C07D211/94 ,  C07D213/80

CPC分类号： C07D498/14 ,  A61K31/5365 ,  C07B2200/13 ,  C07D213/80

摘要： A process for preparing a compound represented by formula (Y1) or (Y2) [wherein R x is an optionally substituted carbocyclyl lower alkyl, or the like] or a salt thereof, using a novel process for preparing a pyridone derivative represented by formula (X4) [wherein R 1d is hydrogen, halogen, or the like; R 2d is hydrogen, a lower alkyl optionally substituted with substituent E, or the like; R 4d is a lower alkyl optionally substituted with substituent E, or the like; and R 6d is a lower alkyl group optionally substituted with substituent group E, or the like].

公开(公告)号：EP3456721A3

公开(公告)日：2019-03-27

申请号：EP18203589.9

申请日：2011-08-04

申请人： Shionogi & Co., Ltd

发明人： SUMINO, Yukihito ,  OKAMOTO, Kazuya ,  MASUI, Moriyasu ,  YAMADA, Daisuke ,  IKARASHI, Fumiya

IPC分类号： C07D498/14 ,  C07D211/94 ,  C07D213/80 ,  A61K31/5365 ,  A61P31/18 ,  A61P43/00

摘要： A process for preparing a compound represented by formula (Y1) or (Y2) [wherein R x is an optionally substituted carbocyclyl lower alkyl, or the like] or a salt thereof, using a novel process for preparing a pyridone derivative represented by formula (X4) [wherein R 1d is hydrogen, halogen, or the like; R 2d is hydrogen, a lower alkyl optionally substituted with substituent E, or the like; R 4d is a lower alkyl optionally substituted with substituent E, or the like; and R 6d is a lower alkyl group optionally substituted with substituent group E].

[Chemical formula 8]

公开(公告)号：EP3127908B1

公开(公告)日：2018-11-28

申请号：EP16190894.2

申请日：2011-08-04

申请人： SHIONOGI & CO., LTD

发明人： SUMINO, Yukihito ,  OKAMOTO, Kazuya ,  MASUI, Moriyasu ,  YAMADA, Daisuke ,  IKARASHI, Fumiya

IPC分类号： C07D498/14

CPC分类号： C07D498/14 ,  A61K31/5365 ,  A61P31/18 ,  A61P43/00 ,  C07B2200/13 ,  C07D211/94 ,  C07D213/80

摘要： A process for preparing a compound represented by formula (Y1) or (Y2) [wherein R x is an optionally substituted carbocyclyl lower alkyl, or the like] or a salt thereof, using a novel process for preparing a pyridone derivative represented by formula (X4) [wherein R 1d is hydrogen, halogen, or the like; R 2d is hydrogen, a lower alkyl optionally substituted with substituent E, or the like; R 4d is a lower alkyl optionally substituted with substituent E, or the like; and R 6d is a lower alkyl group optionally substituted with substituent group E, or the like].

公开(公告)号：EP2412709A1

公开(公告)日：2012-02-01

申请号：EP10756205.0

申请日：2010-03-26

申请人： Shionogi & Co., Ltd.

发明人： SUMINO, Yukihito ,  OKAMOTO, Kazuya ,  MASUI, Moriyasu ,  AKIYAMA, Toshiyuki

IPC分类号： C07D213/80 ,  C07D309/32 ,  C07D405/06

CPC分类号： C07D498/14 ,  C07D213/80 ,  C07D309/32 ,  C07D309/40 ,  C07D405/06 ,  C07D471/04 ,  C07D471/14

摘要： The present invention provides a pyrone derivative and a pyridone derivative, which are novel intermediates for synthesizing an anti-influenza drug, a method of producing the same, and a method of using the same.

摘要翻译： 本发明提供作为合成抗流感药物的新中间体的吡喃酮衍生物和吡啶酮衍生物及其制造方法及其使用方法。