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    ANTI-MUC1 ANTIBODY
    2.
    发明公开
    ANTI-MUC1 ANTIBODY 有权
    抗MUC1-ANTIKÖRPER

    公开(公告)号：EP2351777A1

    公开(公告)日：2011-08-03

    申请号：EP09823638.3

    申请日：2009-10-28

    申请人： Shionogi&Co., Ltd. ,  National University Corporation Hokkaido University

    发明人： NISHIMURA, Shin-Ichiro ,  HINOU, Hiroshi ,  NUMATA, Yoshito ,  ONODA, Junji ,  NAITO, Shoichi ,  OHYABU, Naoki

    IPC分类号： C07K16/30 ,  A61K38/00 ,  A61K39/395 ,  A61K49/00 ,  A61P35/00 ,  A61P43/00 ,  C12N15/13

    CPC分类号： C07K16/00 ,  A61K38/00 ,  A61K2039/505 ,  C07K16/3092 ,  C07K2317/34 ,  C07K2317/732 ,  C07K2317/94

    摘要： An object of the present invention is to provide an antibody which does not bind to a normal cell, and is specific for a cancer cell. The object was solved by the finding by the present inventors that an antibody obtained by immunizing an animal using a 2, 3ST glycopeptide as an antigen unexpectedly recognizes a sugar chain specific for a cancer specifically and remarkably, and consequently, can recognize and kill a cancer cell expressing MUC1 having such a cancer cell-specific sugar chain. The present invention provides, for example, an antibody, an antigen-binding fragment thereof or a MUC1-binding molecule, in which specificity for a cancer-associated structure of MUC1 is 100-fold or more as compared with that for a normal tissue-associated structure of MUC1.

    摘要翻译： 本发明的目的是提供一种不与正常细胞结合并且对癌细胞特异的抗体。 该目的解决了这一发现由本发明人，通过使用2，3ST糖肽作为抗原出乎意料识别特异于癌症的糖链特异性并显着，并因此免疫动物获得的抗体，可以识别并杀死癌细胞 表达具有这种癌细胞特异性糖链的MUC1的细胞。 本发明提供了，例如，抗体，其抗原结合片段或MUC1结合分子，其中作为与用于正常组织 - 相比特异性MUC1的与癌症相关的结构是100倍或更多 MUC1的相关结构。

    COLLAGEN NEOEPITOPE ANTIBODY
    5.
    发明公开
    COLLAGEN NEOEPITOPE ANTIBODY 审中-公开
    胶原NEOEPITOP-ANTIKÖRPER

    公开(公告)号：EP2479190A1

    公开(公告)日：2012-07-25

    申请号：EP10817241.2

    申请日：2010-09-16

    申请人： Shionogi Co., Ltd.

    发明人： NUMATA, Yoshito ,  YAMAUCHI, Akira ,  ONODA, Junji ,  YAMANE, Shoji ,  MAEDA, Tomoko

    IPC分类号： C07K16/18 ,  C12Q1/37 ,  G01N33/53 ,  G01N33/577

    CPC分类号： G01N33/6887 ,  C07K16/18 ,  C07K2317/34 ,  G01N2333/78

    摘要： The present invention provides a novel monoclonal antibody that is specific for a C-terminal neoepitope of a collagen fragment and has substantially equal binding affinity whether proline contained in the neoepitope is in a non-hydroxylated form or in a hydroxylated form, and an immunoassay, a measurement method, a kit and the like using the antibody. The antibody allows for quantification of a collagen fragment generated by digestion of a biological sample with a collagenase present in the sample, regardless of the presence or absence of a hydroxylated form of proline in the neoepitope.

    摘要翻译： 本发明提供了一种对胶原片段的C末端新表皮特异的新型单克隆抗体，并且具有与新表皮中所含的脯氨酸呈非羟基化形式或羟基化形式的免疫测定法相当的结合亲和力， 使用该抗体的测定方法，试剂盒等。 抗体允许通过用存在于样品中的胶原酶消化生物样品而产生的胶原片段进行定量，而不管新表皮中是否存在羟基化形式的脯氨酸。

    MONOCLONAL ANTIBODY HAVING NEUTRALIZING ACTIVITY AGAINST MMP13
    8.
    发明公开
    MONOCLONAL ANTIBODY HAVING NEUTRALIZING ACTIVITY AGAINST MMP13 审中-公开
    MONOKLONALER ANTIKORPER MIT中性粒细胞

    公开(公告)号：EP2186894A1

    公开(公告)日：2010-05-19

    申请号：EP08790943.8

    申请日：2008-07-08

    申请人： Shionogi&Co., Ltd.

    发明人： NAITO, Shoichi ,  ONODA, Junji ,  YAMAUCHI, Akira ,  NUMATA, Yoshito ,  KISHINO, Junji

    IPC分类号： C12N15/09 ,  A61K39/395 ,  A61P19/02 ,  C07K16/40 ,  C12N5/10 ,  C12P21/08 ,  G01N33/573

    CPC分类号： G01N33/573 ,  C07K16/40 ,  C07K2317/76 ,  G01N2333/8146

    摘要： A neutralizing monoclonal antibody specifically reacting with MMP13, a method of neutralizing enzyme activity of MMP13 and an immunological measuring method each using the antibody, as well as a diagnostic agent and a pharmaceutical composition containing the antibody, are provided. Various antibodies to MMP13 have been hitherto obtained, but an antibody having neutralizing activity against MMP13 has not been obtained. The present inventors intensively studied, as a result, found out a neutralizing antibody having specificity for MMP13, resulting in completion of the present invention.

    摘要翻译： 提供了与MMP13特异性反应的中和单克隆抗体，中和MMP13的酶活性的方法和各自使用该抗体的免疫学测定方法，以及含有抗体的诊断剂和药物组合物。 迄今为止已经获得了MMP13的各种抗体，但是尚未获得具有针对MMP13的中和活性的抗体。 本发明人深入研究了结果，发现了对MMP13具有特异性的中和抗体，从而完成了本发明。