公开(公告)号：EP4317439A1

公开(公告)日：2024-02-07

申请号：EP22781256.7

申请日：2022-03-31

申请人： Shionogi & Co., Ltd ,  OSAKA UNIVERSITY

发明人： YOSHIDA, Tetsuya ,  YOSHIKAWA, Mai ,  HARUNA, Miya ,  NAGIRA, Morio ,  TAKAHASHI, Koji ,  HAYASHIDA, Marina ,  MIWA, Hiroto ,  SONODA, Yudai ,  OHKURA, Naganari ,  SAKAGUCHI, Shimon ,  WADA, Hisashi

IPC分类号： C12N15/62 ,  A61K35/17 ,  A61P35/00 ,  C07K14/725 ,  C07K16/28 ,  C07K19/00 ,  C12N5/10 ,  C12N15/12 ,  C12N15/13 ,  C12N15/63

摘要： The chimeric antigen receptor that recognizes CCR8 as an antigen of the present invention has cytotoxic activity against CCR8-expressing cells by being expressed in effector cells.

公开(公告)号：EP4428239A1

公开(公告)日：2024-09-11

申请号：EP22887213.1

申请日：2022-10-31

申请人： Shionogi & Co., Ltd

发明人： YOSHIKAWA, Mai ,  ONODA, Junji ,  NAKAMORI, Daiki ,  TAKAHASHI, Tatsuya ,  KASAI, Erika

IPC分类号： C12N15/13 ,  A61K39/395 ,  A61P17/04 ,  A61P25/04 ,  A61P29/00 ,  A61P29/02 ,  C07K16/18 ,  C07K16/28 ,  C12N15/63

CPC分类号： A61K39/395 ,  A61P17/04 ,  A61P25/04 ,  A61P29/00 ,  A61P29/02 ,  C07K16/00 ,  C07K16/18 ,  C07K16/28 ,  C12N15/63

摘要： Objective of the present invention is to provide a novel Nav1.7 monoclonal antibody. It discloses a Nav1.7 monoclonal antibody or its antibody fragment, having specific six CDRs or specific heavy chain variable regions/light chain variable regions. The monoclonal antibody and the like can be used for treating or preventing pain, pruritus and so on.