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公开(公告)号：EP3736268A1
公开(公告)日：2020-11-11
申请号：EP20178220.8
申请日：2014-12-19
发明人： CASHION, Daniel Kurt , MORTENSEN, Deborah , HUANG, Dehua , TORRES, Eduardo , PARNES, Jason , SAPIENZA, John , HANSEN, Joshua , LEFTHERIS, Katerina , CORREA, Matthew , DELGADO, Maria Mercedes , RAHEJA, Raj , PAPA, Patrick , BAHMANYAR, Sogole , HEGDE, Sayee , NORRIS, Stephen Tyson , PLANTEVIN-KRENITSKY, Veronique , CALABRESE, Andrew Antony , CATHERS, Brian Edwin , WHITEFIELD, Brandon Wade , BENNETT, Brydon
IPC分类号： C07D239/48 , C07D403/06 , A61K31/506 , A61P3/00 , A61P11/00 , A61P11/06 , A61P17/00 , A61P19/00 , A61P21/00 , A61P37/06 , C07D405/14 , A61K31/505 , A61K31/5377 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04
摘要： The invention provides a method for preparing a compound of formula (I):
comprising contacting a compound of formula (Ia)
or a compound of formula (Ic)
with R 1 -L-NH 2 , in an organic solvent, in the presence of a base, under conditions as defined herein. Also provided are reaction intermediates involved in said method as defined herein.-
2.发明授权HALOARYL SUBSTITUTED AMINOPURINES, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH 有权卤代芳基取代氨基嘌呤，THEREOF组合物和治疗方法，这些方法
公开(公告)号：EP2010186B1
公开(公告)日：2012-12-26
申请号：EP07756113.2
申请日：2007-04-25
发明人： ALBERS, Ronald, J. , AYALA, Leticia , CLAREEN, Steven, S. , DELGADO MEDEROS, Maria, Mercedes , HILGRAF, Robert , HEGDE, Sayee,G., c/o Wilson Sonsini Goodrich ... , HUGHES, Kevin , KOIS, Adam , PLANTEVIN-KRENITSKY, Veronique , MCCARRICK, Meg , NADOLNY, Lisa , PALANKI,Moorthy, S.S. , SAHASRAMUDHE, Kiran c/o Wilson Sonsini Goodrich , SAPIENZA, John , SATOH, Yoshitaka , SLOSS, Marianne, K. , SUDBECK, Elise , WRIGHT, Jonathan
CPC分类号： A61K31/52 , C07D473/32
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3.发明授权HALOARYL SUBSTITUTED AMINOPURINES, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH 有权卤代芳基取代氨基嘌呤，THEREOF组合物和治疗方法，这些方法
公开(公告)号：EP1838710B1
公开(公告)日：2009-07-01
申请号：EP06718361.6
申请日：2006-01-13
发明人： ALBERS, Ronald , AYALA, Leticia , CLAREEN, Steven, S. , DELGADO MEDEROS, Maria, M. , HILGRAF, Robert , HEDGE, Sayee , HUGHES, Kevin , KOIS, Adam , PLANTEVIN-KRENITSKY, Veronique , MCCARRICK, Meg , NADOLNY, Lisa , PALANKI, Moorthy , SAHASRABUDHE, Kiran , SAPIENZA, John , SATOH, Yoshitaka , SLOSS, Marian , SUDBECK, Elise , WRIGHT, Jonathan , COLE, Andrew G. , HENDERSON, Ian
IPC分类号： C07D473/00 , C07D473/32 , A61K31/52 , A61P3/00 , A61P9/00
CPC分类号： C07D473/00 , A61K31/52 , C07D473/32
摘要： Provided herein are Aminopurine Compounds having the following structure: (I) wherein R1 , R2 and and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound and methods for treating or preventing cancer, a cardiovascular disease, a renal disease, an autoimmune condition, an inflammatory condition, macular degeneration, ischemia-reperfusion injury, pain and related syndromes, disease-related wasting, an asbestos-related condition, pulmonary hypertension or a condition treatable or preventable by inhibition of the JNK pathway comprising administering an effective amount of an Aminopurine Compound to a patient in need thereof.
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4.发明公开HALOARYL SUBSTITUTED AMINOPURINES, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH 有权卤代取代的氨基酸，其组合物及其治疗方法
公开(公告)号：EP2010186A1
公开(公告)日：2009-01-07
申请号：EP07756113.2
申请日：2007-04-25
发明人： ALBERS, Ronald, J. , AYALA, Leticia , CLAREEN, Steven, S. , DELGADO MEDEROS, Maria, Mercedes , HILGRAF, Robert , HEGDE, Sayee, G. , HUGHES, Kevin , KOIS, Adam , PLANTEVIN-KRENITSKY, Veronique , MCCARRICK, Meg , NADOLNY, Lisa , PALANKI,Moorthy, S.S. , SAHASRAMUDHE, Kiran , SAPIENZA, John , SATOH, Yoshitaka , SLOSS, Marianne, K. , SUDBECK, Elise , WRIGHT, Jonathan
CPC分类号： A61K31/52 , C07D473/32
摘要： Provided herein are Aminopurine Compounds having the following structure (I), wherein R1, R2 and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine. Compound and methods for treating or preventing cancer, a cardiovascular disease, a renal disease, an autoimmune condition, an inflammatory condition, macular degeneration, ischemia-reperfusion injury, pain and related syndromes, disease-related wasting, an asbestos-related condition, pulmonary hypertension or a condition treatable or preventable by inhibition of the JNK pathway comprising administering an effective amount of an Aminopurine Compound to a patient in need thereof.
摘要翻译： 本文提供具有以下结构（I）的氨嘌呤化合物，其中R 1，R 2和R 3如本文所定义，包含有效量的氨基嘌呤的组合物。 用于治疗或预防癌症，心血管疾病，肾脏疾病，自身免疫病症，炎性病症，黄斑变性，缺血 - 再灌注损伤，疼痛和相关综合征，疾病相关性消耗，石棉相关病症，肺部疾病 高血压或通过抑制JNK途径可治疗或可预防的病症，所述方法包括向有需要的患者施用有效量的氨嘌呤化合物。
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5.发明公开SUBSTITUTED DIAMINOPYRIMIDYL COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH 审中-公开替代品DIAMINOPYRIMIDYLVERBINDUNGEN，ZUSAMMENSETZUNGEN DAVON UND BEHANDLUNGSVERFAHREN DAMIT
公开(公告)号：EP3082819A1
公开(公告)日：2016-10-26
申请号：EP14871136.9
申请日：2014-12-19
发明人： CASHION, Daniel , MORTENSEN, Deborah , HUANG, Dehua , TORRES, Eduardo , PARNES, Jason , SAPIENZA, John , HANSEN, Joshua , LEFTHERIS, Katerina , CORREA, Matthew , DELGADO, Maria, Mercedes , RAHEJA, Raj , PAPA, Patrick , BAHMANYAR, Sogole , HEGDE, Sayee , NORRIS, Stephen Tyson , PLANTEVIN-KRENITSKY, Veronique , CALABRESE, Andrew, Antony , CATHERS, Brian, Edwin , WHITEFIELD, Brandon, Wade , BENNETT, Brydon
IPC分类号： A61K31/506 , C07D239/48
CPC分类号： C07D239/48 , A61K31/505 , A61K31/506 , A61K31/5377 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04
摘要： Provided herein are diaminopyrimidyl Compounds having the following structures: wherein X, L, R1, and R2 are as defined herein, compositions comprising an effective amount of a Diaminopyrimidyl Compound, and methods for treating or preventing PKC-theta-mediated disorders, or a condition treatable or preventable by inhibition of a kinase, for example, PKC-theta.
摘要翻译： 本文提供具有以下结构的二氨基嘧啶化合物：其中X，L，R 1和R 2如本文所定义，包含有效量的二氨基嘧啶基化合物的组合物，以及治疗或预防PKC-θ介导的病症的方法或病症 可通过抑制激酶例如PKC-θ治疗或预防。
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公开(公告)号：EP2344494B1
公开(公告)日：2016-04-20
申请号：EP09789271.5
申请日：2009-09-08
发明人： BAHMANYAR, Sogole , BATES, R.J. , BLEASE, Kate , CALABRESE, Andrew, Antony , DANIEL, Thomas, Oran , DELGADO, Mercedes , ELSNER, Jan , ERDMAN, Paul , FAHR, Bruce , FERGUSON, Gregory , LEE, Branden , NADOLNY, Lisa , PACKARD, Garrick , PAPA, Patrick , PLANTEVIN-KRENITSKY, Veronique , RIGGS, Jennifer , ROHANE, Patricia , SANKAR, Sabita , SAPIENZA, John , SATOH, Yoshitaka , SLOAN, Victor , STEVENS, Randall , TEHRANI, Lida , TIKHE, Jayashree , TORRES, Eduardo , WALLACE, Andrew , WHITEFIELD, Brandon, Wade , ZHAO, Jingjing
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00 , A61P5/00 , A61P25/00 , A61P9/00 , A61P19/00 , A61P29/00
CPC分类号： C07D471/04 , C07D519/00
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公开(公告)号：EP2344494A1
公开(公告)日：2011-07-20
申请号：EP09789271.5
申请日：2009-09-08
发明人： BAHMANYAR, Sogole , BATES, R.J. , BLEASE, Kate , CALABRESE, Andrew, Antony , DANIEL, Thomas, Oran , DELGADO, Mercedes , ELSNER, Jan , ERDMAN, Paul , FAHR, Bruce , FERGUSON, Gregory , LEE, Branden , NADOLNY, Lisa , PACKARD, Garrick , PAPA, Patrick , PLANTEVIN-KRENITSKY, Veronique , RIGGS, Jennifer , ROHANE, Patricia , SANKAR, Sabita , SAPIENZA, John , SATOH, Yoshitaka , SLOAN, Victor , STEVENS, Randall , TEHRANI, Lida , TIKHE, Jayashree , TORRES, Eduardo , WALLACE, Andrew , WHITEFIELD, Brandon, Wade , ZHAO, Jingjing
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00 , A61P5/00 , A61P25/00 , A61P9/00 , A61P19/00 , A61P29/00
CPC分类号： C07D471/04 , C07D519/00
摘要： Provided herein are Heteroaryl Compounds of formula (I): wherein R
1 and R
2 are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing inflammatory conditions or cancer, and conditions treatable or preventable by inhibition of a kinase or a kinase pathway comprising administering an effective amount of a Heteroaryl Compound to a subject in need thereof.
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