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1.发明公开
公开(公告)号：EP1692128A1
公开(公告)日：2006-08-23
申请号：EP04811774.1
申请日：2004-11-19
发明人： BHAGWAT, Shripad, S. , SATOH, Yoshitaka , SAKATA, Steven, T. , BUHR, Chris, A. , ALBERS, Ronald , SAPIENZA, John , PLANTEVIN, Veronique , CHAO, Qi , SAHASRABUDHE, Kiran , FERRY, Rachel , NARLA, Rama, K.
IPC分类号： C07D403/04 , C07D401/14 , C07D403/14 , C07D403/12 , A61K31/416 , A61K31/4196
CPC分类号： C07D403/12 , C07D401/14 , C07D403/04 , C07D403/14
摘要： This invention is directed to Indazole Compounds or pharmaceutically acceptable salts, solvates and hydrates thereof. The Indazole Compounds have utility in the treatment or prevention of a wide range of diseases and disorders that are responsive to the inhibition, modulation or regulation of kinases, such as inflammatory diseases, abnormal angiogenesis and diseases related thereto, cancer, atherosclerosis, a cardiovascular disease, a renal disease, an autoimmune condition, macular degeneration, disease-related wasting, an asbestos-related condition, pulmonary hypertension, diabetes, obesity, pain and others. Thus, methods of treating or preventing such diseases and disorders are also disclosed, as are pharmaceutical compositions comprising one or more of the Indazole Compounds. This invention is based, in part, upon the discovery of a novel class of 5-triazolyl substituted indazole molecules that have potent activity with respect to the modulation of protein kinases. Thus, the invention encompasses orally active molecules as well as parenterally active molecules which can be used at lower doses or serum concentrations for treating diseses or disorders associated with protein kinase signal transduction.
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2.发明公开SUBSTITUTED DIAMINOCARBOXAMIDE AND DIAMINOCARBONITRILE PYRIMIDINES, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH 审中-公开取代DIAMINOCARBOXAMID-和DIAMINOCARBONITRILPYRIMIDINE，THEREOF组合物和治疗方法，这些方法
公开(公告)号：EP2699553A1
公开(公告)日：2014-02-26
申请号：EP12718524.7
申请日：2012-04-20
发明人： BENNETT, Brydon, L. , ELSNER, Jan , ERDMAN, Paul , HILGRAF, Robert , LEBRUN, Laurie, Ann , MCCARRICK, Meg , MOGHADDAM, Mehran, F. , NAGY, Mark, A. , NORRIS, Stephen , PAISNER, David, A. , SLOSS, Marianne , ROMANOW, William, J. , SATOH, Yoshitaka , TIKHE, Jayashree , YOON, Won, Hyung , DELGADO, Mercedes
IPC分类号： C07D239/48 , C07D405/02 , C07D401/12 , C07D409/12
CPC分类号： C07D239/48 , A61K31/505 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12
摘要： Provided herein are Diaminopyrimidine Compounds having the following structures: wherein R
1 , R
2 , R
3, and R
4 are as defined herein, compositions comprising an effective amount of a Diaminopyrimidine Compound, and methods for treating or preventing liver fibrotic disorders or a condition treatable or preventable by inhibition of a JNK pathway.-
3.发明授权HALOARYL SUBSTITUTED AMINOPURINES, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH 有权卤代芳基取代氨基嘌呤，THEREOF组合物和治疗方法，这些方法
公开(公告)号：EP2010186B1
公开(公告)日：2012-12-26
申请号：EP07756113.2
申请日：2007-04-25
发明人： ALBERS, Ronald, J. , AYALA, Leticia , CLAREEN, Steven, S. , DELGADO MEDEROS, Maria, Mercedes , HILGRAF, Robert , HEGDE, Sayee,G., c/o Wilson Sonsini Goodrich ... , HUGHES, Kevin , KOIS, Adam , PLANTEVIN-KRENITSKY, Veronique , MCCARRICK, Meg , NADOLNY, Lisa , PALANKI,Moorthy, S.S. , SAHASRAMUDHE, Kiran c/o Wilson Sonsini Goodrich , SAPIENZA, John , SATOH, Yoshitaka , SLOSS, Marianne, K. , SUDBECK, Elise , WRIGHT, Jonathan
CPC分类号： A61K31/52 , C07D473/32
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4.发明授权HALOARYL SUBSTITUTED AMINOPURINES, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH 有权卤代芳基取代氨基嘌呤，THEREOF组合物和治疗方法，这些方法
公开(公告)号：EP1838710B1
公开(公告)日：2009-07-01
申请号：EP06718361.6
申请日：2006-01-13
发明人： ALBERS, Ronald , AYALA, Leticia , CLAREEN, Steven, S. , DELGADO MEDEROS, Maria, M. , HILGRAF, Robert , HEDGE, Sayee , HUGHES, Kevin , KOIS, Adam , PLANTEVIN-KRENITSKY, Veronique , MCCARRICK, Meg , NADOLNY, Lisa , PALANKI, Moorthy , SAHASRABUDHE, Kiran , SAPIENZA, John , SATOH, Yoshitaka , SLOSS, Marian , SUDBECK, Elise , WRIGHT, Jonathan , COLE, Andrew G. , HENDERSON, Ian
IPC分类号： C07D473/00 , C07D473/32 , A61K31/52 , A61P3/00 , A61P9/00
CPC分类号： C07D473/00 , A61K31/52 , C07D473/32
摘要： Provided herein are Aminopurine Compounds having the following structure: (I) wherein R1 , R2 and and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound and methods for treating or preventing cancer, a cardiovascular disease, a renal disease, an autoimmune condition, an inflammatory condition, macular degeneration, ischemia-reperfusion injury, pain and related syndromes, disease-related wasting, an asbestos-related condition, pulmonary hypertension or a condition treatable or preventable by inhibition of the JNK pathway comprising administering an effective amount of an Aminopurine Compound to a patient in need thereof.
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5.发明公开HALOARYL SUBSTITUTED AMINOPURINES, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH 有权卤代取代的氨基酸，其组合物及其治疗方法
公开(公告)号：EP2010186A1
公开(公告)日：2009-01-07
申请号：EP07756113.2
申请日：2007-04-25
发明人： ALBERS, Ronald, J. , AYALA, Leticia , CLAREEN, Steven, S. , DELGADO MEDEROS, Maria, Mercedes , HILGRAF, Robert , HEGDE, Sayee, G. , HUGHES, Kevin , KOIS, Adam , PLANTEVIN-KRENITSKY, Veronique , MCCARRICK, Meg , NADOLNY, Lisa , PALANKI,Moorthy, S.S. , SAHASRAMUDHE, Kiran , SAPIENZA, John , SATOH, Yoshitaka , SLOSS, Marianne, K. , SUDBECK, Elise , WRIGHT, Jonathan
CPC分类号： A61K31/52 , C07D473/32
摘要： Provided herein are Aminopurine Compounds having the following structure (I), wherein R1, R2 and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine. Compound and methods for treating or preventing cancer, a cardiovascular disease, a renal disease, an autoimmune condition, an inflammatory condition, macular degeneration, ischemia-reperfusion injury, pain and related syndromes, disease-related wasting, an asbestos-related condition, pulmonary hypertension or a condition treatable or preventable by inhibition of the JNK pathway comprising administering an effective amount of an Aminopurine Compound to a patient in need thereof.
摘要翻译： 本文提供具有以下结构（I）的氨嘌呤化合物，其中R 1，R 2和R 3如本文所定义，包含有效量的氨基嘌呤的组合物。 用于治疗或预防癌症，心血管疾病，肾脏疾病，自身免疫病症，炎性病症，黄斑变性，缺血 - 再灌注损伤，疼痛和相关综合征，疾病相关性消耗，石棉相关病症，肺部疾病 高血压或通过抑制JNK途径可治疗或可预防的病症，所述方法包括向有需要的患者施用有效量的氨嘌呤化合物。
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公开(公告)号：EP2344494B1
公开(公告)日：2016-04-20
申请号：EP09789271.5
申请日：2009-09-08
发明人： BAHMANYAR, Sogole , BATES, R.J. , BLEASE, Kate , CALABRESE, Andrew, Antony , DANIEL, Thomas, Oran , DELGADO, Mercedes , ELSNER, Jan , ERDMAN, Paul , FAHR, Bruce , FERGUSON, Gregory , LEE, Branden , NADOLNY, Lisa , PACKARD, Garrick , PAPA, Patrick , PLANTEVIN-KRENITSKY, Veronique , RIGGS, Jennifer , ROHANE, Patricia , SANKAR, Sabita , SAPIENZA, John , SATOH, Yoshitaka , SLOAN, Victor , STEVENS, Randall , TEHRANI, Lida , TIKHE, Jayashree , TORRES, Eduardo , WALLACE, Andrew , WHITEFIELD, Brandon, Wade , ZHAO, Jingjing
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00 , A61P5/00 , A61P25/00 , A61P9/00 , A61P19/00 , A61P29/00
CPC分类号： C07D471/04 , C07D519/00
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公开(公告)号：EP2344494A1
公开(公告)日：2011-07-20
申请号：EP09789271.5
申请日：2009-09-08
发明人： BAHMANYAR, Sogole , BATES, R.J. , BLEASE, Kate , CALABRESE, Andrew, Antony , DANIEL, Thomas, Oran , DELGADO, Mercedes , ELSNER, Jan , ERDMAN, Paul , FAHR, Bruce , FERGUSON, Gregory , LEE, Branden , NADOLNY, Lisa , PACKARD, Garrick , PAPA, Patrick , PLANTEVIN-KRENITSKY, Veronique , RIGGS, Jennifer , ROHANE, Patricia , SANKAR, Sabita , SAPIENZA, John , SATOH, Yoshitaka , SLOAN, Victor , STEVENS, Randall , TEHRANI, Lida , TIKHE, Jayashree , TORRES, Eduardo , WALLACE, Andrew , WHITEFIELD, Brandon, Wade , ZHAO, Jingjing
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00 , A61P5/00 , A61P25/00 , A61P9/00 , A61P19/00 , A61P29/00
CPC分类号： C07D471/04 , C07D519/00
摘要： Provided herein are Heteroaryl Compounds of formula (I): wherein R
1 and R
2 are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing inflammatory conditions or cancer, and conditions treatable or preventable by inhibition of a kinase or a kinase pathway comprising administering an effective amount of a Heteroaryl Compound to a subject in need thereof.-
8.发明公开
公开(公告)号：EP4328223A3
公开(公告)日：2024-11-06
申请号：EP23205984.0
申请日：2012-04-20
发明人： BENNETT, Brydon , ELSNER, Jan , ERDMAN, Paul , HILGRAF, Robert , LEBRUN, Laurie Ann , MCCARRICK, Meg , MOGHADDAM, Mehran , NAGY, Mark A. , NORRIS, Stephen , PAISNER, David A. , SLOSS, Marianne , ROMANOW, William J. , SATOH, Yoshitaka , TIKHE, Jayashree , YOON, Won Hyung , DELGADO, Maria Mercedes
IPC分类号： C07D239/48 , C07D405/02 , C07D401/12 , C07D409/12
摘要： Provided herein is a compound of formula (I)
or a pharmaceutically acceptable salt, tautomer, stereoisomer, enantiomer, isotopologue, or prodrug thereof, wherein R 1 and R 2 are as defined herein. Also provided are methods and reaction intermediates for preparing said compound.-
9.发明授权ANILINOPYRIMIDINE DERIVATIVES AS JNK PATHWAY INHIBITORS AND COMPOSITIONS AND METHODS RELATED THERETO 有权苯胺嘧啶衍生物作为“JNK通路抑制剂”组合物和相关技术
公开(公告)号：EP1349840B1
公开(公告)日：2009-03-11
申请号：EP01996103.6
申请日：2001-12-05
发明人： KOIS, Adam , MACFARLANE, Karen, J. , SATOH, Yoshitaka , BHAGWAT, Shripad, S. , PARNES, Jason, S. , PALANKI, Moorthy, S., S. , ERDMAN, Paul, E.
IPC分类号： C07D239/00
CPC分类号： C07D239/42 , A61K31/496 , A61K31/505 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D487/08 , C07D491/10 , A61K2300/00
摘要： Compounds having activity as inhibitors of the JNK pathway are disclosed. The compounds of this invention are anilinopyrimidine derivatives having the following structure: (I) wherein R1 through R6 are as defined herein. Such compounds have utility in the treatment of a wide range of conditions that are responsive to inhibition of the JNK pathway. Thus, methods of treating such conditions are also disclosed, as are pharmaceutical compositions containing one or more compounds of the above compounds.
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公开(公告)号：EP1618093A2
公开(公告)日：2006-01-25
申请号：EP04750298.4
申请日：2004-04-16
发明人： BHAGWAT, Shripad, S. , SATOH, Yoshitaka , SAKATA, Steven, T. , BUHR, Chris, A. , ALBERS, Ronald , SAPIENZA, John , PLANTEVIN, Veronique , CHAO, Qi , SAHASRABUDHE, Kiran , FERRI, Rachel
IPC分类号： C07D231/56 , C07D401/12 , C07D409/12 , C07D403/12 , C07D403/04 , C07D405/14 , C07D405/12 , C07D413/12 , C07D409/14 , C07D401/14 , C07D403/14 , C07D401/04 , A61K31/416 , A61P19/00 , C07D405/04
CPC分类号： C07D403/06 , A61K31/416 , C07D231/56 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/12
摘要： This invention is generally directed to Indazole Derivatives having the following structure (I) or pharmaceutically acceptable salt thereof, wherein R1, R2 and A are as defined herein. Such compounds have utility in the treatment of a wide range of diseases and disorders that are responsive to JNK inhibition, such as an inflammatory disease or disorder. Thus, methods of treating such diseases and disorders are also disclosed, as are pharmaceutical compositions containing one or more compounds of the above compounds.
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