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公开(公告)号：EP1490047B1
公开(公告)日：2009-12-30
申请号：EP03719457.8
申请日：2003-03-26
发明人： THOMPSON, Scott, K. , FRAZEE, James, S. , KALLANDER, Lara, S. , MA, Chum , MARINO, Joseph, P. , NEEB, Michael, J. , BHAT, Ajita
IPC分类号： A61K31/34 , A61K31/38 , A61K31/40 , C07D209/14 , C07D209/16 , C07D307/81 , C07D333/58 , C07D407/12 , A61P9/00
CPC分类号： C07D307/81 , C07D307/79 , C07D407/12
摘要： Disclosed is a compound of having the formula: (I) pharmaceutically acceptable salts or solvates thereof and pharmaceutical compositions containing the same, wherein the structural variables are as defined herein. The compounds, salts and solvates of this invention are useful as LXR agonists.
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公开(公告)号：EP1954133A2
公开(公告)日：2008-08-13
申请号：EP06840048.0
申请日：2006-11-29
发明人： FRAZEE, James, S. , JOHNSON, Latisha, C. , HAMMOND, Marlys , KALLANDER, Lara, S. , STOY, Patrick , THOMPSON, Scott, Kevin , WASHBURN, David, G.
IPC分类号： A01N43/00 , A61K31/397 , A61K31/407
CPC分类号： C07D401/12 , C07D207/12 , C07D207/14 , C07D207/48 , C07D401/04 , C07D403/06 , C07D405/06 , C07D405/12 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/06 , C07D417/06
摘要： The present invention relates to a compotind represented by the following formula I or a pharmaceutically acceptable salt thereof; wherein R1, R2, and y are defined herein. The present invention further relates to compositions that include the compound of the present invention as well as a method of treating a patient from endometreosis or uterine fibroids.
摘要翻译： 本发明涉及由下式I表示的化合物或其药学上可接受的盐; 其中R1，R2和y如本文所定义。 本发明还涉及包含本发明化合物的组合物以及治疗患有子宫内膜异位症或子宫肌瘤的患者的方法。
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公开(公告)号：EP1497270A1
公开(公告)日：2005-01-19
申请号：EP03716872.1
申请日：2003-03-26
发明人： THOMPSON, Scott, K. , FRAZEE, James, S. , KALLANDER, Lara, S. , MA, Chun,Apartment 3G , MARINO, Joseph, P. , NEEB, Michael, J. , WANG, Ning
IPC分类号： C07D265/30 , C07D295/06 , C07D211/06 , C07D241/04 , C07D207/08 , C07C233/05 , C07C311/15 , A61K31/535 , A61K31/165 , A61K31/445 , A61K31/495 , A61K31/40 , A61K31/395 , A61K31/55 , A61K31/18 , A61K31/16
CPC分类号： C07D213/40 , C07C235/34 , C07C235/46 , C07C311/51 , C07D205/04 , C07D207/09 , C07D213/38 , C07D223/04 , C07D233/24 , C07D233/64 , C07D249/08 , C07D261/08 , C07D271/10 , C07D277/28 , C07D295/13 , C07D295/185 , C07D295/192 , C07D307/14 , C07D307/52 , C07D333/20 , C07D333/38
摘要： Disclosed is a compound having the formula (I) pharmaceutically acceptable salts or solvates thereof and pharmaceutical compositions containing the same, wherein the structural variables are as defined herein. The compounds, salts and solvates of this invention are useful as LXR agonists.
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公开(公告)号：EP1490047A2
公开(公告)日：2004-12-29
申请号：EP03719457.8
申请日：2003-03-26
发明人： THOMPSON, Scott, K. , FRAZEE, James, S. , KALLANDER, Lara, S. , MA, Chum , MARINO, Joseph, P. , NEEB, Michael, J. , BHAT, Ajita
IPC分类号： A61K31/34 , A61K31/38 , A61K31/40 , C07D209/14 , C07D209/16 , C07D307/81 , C07D333/58
CPC分类号： C07D307/81 , C07D307/79 , C07D407/12
摘要： Disclosed is a compound of having the formula: (I) pharmaceutically acceptable salts or solvates thereof and pharmaceutical compositions containing the same, wherein the structural variables are as defined herein. The compounds, salts and solvates of this invention are useful as LXR agonists.
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5.发明公开ACID AND ESTER COMPOUNDS AND METHODS OF USING THE SAME 审中-公开Sereure- UND ESTERVERBINDUNGEN UND VERFAHREN ZU DEREN ANWENDUNG
公开(公告)号：EP1487776A1
公开(公告)日：2004-12-22
申请号：EP03718068.4
申请日：2003-03-26
IPC分类号： C07C205/00 , C07C229/00 , C07C69/76 , C07C51/23 , C07C213/00 , C07C43/00 , C09B11/02
CPC分类号： C07D213/38 , C07B2200/07 , C07C45/515 , C07C47/24 , C07C217/18 , C07C217/22 , C07C217/36 , C07C217/58 , C07C2601/08
摘要： Disclosed is a compound of having the formula (II-A), pharmaceutically acceptable salts or solvates thereof and pharmaceutical compositions containing the same, wherein the structural variables are as defined herein. The compounds, salts and solvates of this invention are useful as LXR agonists.
摘要翻译： 公开了具有下式的化合物：其药学上可接受的盐或溶剂化物和含有该化合物的药物组合物，其中结构变量如本文所定义。 本发明的化合物，盐和溶剂化物可用作LXR激动剂。
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公开(公告)号：EP1871379A2
公开(公告)日：2008-01-02
申请号：EP06750349.0
申请日：2006-04-14
发明人： JONES, David, G. , KALDOR, Istvan , LIANG, Xi , TURNBULL, Philip, Stewart , HAMMOND, Marlys , KALLANDER, Lara, S. , THOMPSON, Scott, Kevin , WASHBURN, David
IPC分类号： A61K31/535 , A61K31/38 , A61K31/335 , A61K31/445 , A61K31/44 , A61K31/275 , C07D211/72 , C07D211/56 , C07D265/30 , C07D279/12 , C07D307/02 , C07D333/22 , C07C255/50
CPC分类号： C07C255/58 , C07D205/04 , C07D213/38 , C07D277/04 , C07D295/185 , C07D307/52 , C07D333/20
摘要： The present invention relates to a compound represented by the following formula (I) or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof, or a combination thereof; wherein R°, R1, R1', R2, R2', R3 and n are defined herein. The present invention further relates to a method of treating a patient from endometreosis or uterine fibroids.
摘要翻译： 本发明涉及由下式（I）表示的化合物或其药学上可接受的盐，或其药学上可接受的溶剂化物，或其组合; 其中R 0，R 1，R 1'，R 2，R 2'，R 3和n如本文所定义。 本发明还涉及治疗子宫内膜异位症或子宫肌瘤患者的方法。
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公开(公告)号：EP1575495A2
公开(公告)日：2005-09-21
申请号：EP03745638.1
申请日：2003-03-26
发明人： THOMPSON, Scott, K. , FRAZEE, James, S. , KALLANDER, Lara, S. , MA, Chun , MARINO, Joseph, P. , NEEB, Michael, J. , BHAT, Ajita , MCATEE, John, Jeffrey , STAVENGER, Robert, A.
IPC分类号： A61K6/00
CPC分类号： C07C311/29 , C07C217/18 , C07C217/20 , C07C217/22 , C07C217/36 , C07C219/22 , C07C229/34 , C07C233/25 , C07C271/28 , C07C275/34 , C07C291/02 , C07C309/73 , C07C311/08 , C07C311/09 , C07C311/21 , C07C323/32 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07D211/34 , C07D211/60 , C07D213/38 , C07D213/64 , C07D213/74 , C07D231/14 , C07D233/64 , C07D239/42 , C07D249/08 , C07D257/04 , C07D295/096 , C07D295/125 , C07D295/185 , C07D307/66 , C07D307/68 , C07D317/58 , C07D317/68 , C07D319/18 , C07D333/20
摘要： Disclosed is a compound having the formula (I) pharmaceutically acceptable salts or solvates thereof and pharmaceutical compositions containing the same, wherein the structural variables are as defined herein. The compounds, salts and solvates of this invention are useful as LXR agonists.
摘要翻译： 公开了具有下式的化合物：其药学上可接受的盐或溶剂合物和含有该化合物的药物组合物，其中结构变量如本文所定义。 本发明的化合物，盐和溶剂化物可用作LXR激动剂。
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公开(公告)号：EP1434772A1
公开(公告)日：2004-07-07
申请号：EP02801058.5
申请日：2002-10-11
IPC分类号： C07D401/04 , C07D403/04 , A61K31/4192 , A61P19/02 , A61P29/00 , A61P35/00
CPC分类号： C07D401/04 , A61K31/4192 , A61K31/4439 , A61K31/4725 , A61K31/506 , C07D249/06
摘要： Disclosed are compounds of formula (I) wherein the formula variables are as defined herein. The compounds of this invention are non-peptide, reversible inhibitors of type 2 methionine aminopeptidase. Also disclosed is the use of such compounds in treating conditions mediated by angiogenesis, such as cancer, haemangioma, proliferative retinopathy, rheumatoid arthritis, atherosclerotic neovascularization, psoriasis, ocular neovascularization and obesity.
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公开(公告)号：EP1274424A1
公开(公告)日：2003-01-15
申请号：EP01926914.1
申请日：2001-04-12
IPC分类号： A61K31/41 , A61K31/44 , C07C211/00 , C07C315/00 , C07D303/00 , C07D307/00
CPC分类号： C07D401/04 , A61K31/4192 , A61K31/4439 , C07C211/48 , C07C323/09 , C07D249/04 , C07D249/06 , C07D403/04 , C07D405/04 , C07D405/12 , C07D409/04
摘要： Compounds of this invention are non-peptide, reversible inhibitors of type 2 methionine aminopeptidase, useful in treating conditions mediated by angiogenesis, such as cancer, haemangioma, proliferative retinophathy, rheumatoid arthritis, atherosclerotic neovascularization, psoriasis, ocular neovascularization and obesity.
摘要翻译： 本发明的化合物是用于治疗由血管生成介导的病症如癌症，血管瘤，增生性视网膜病，类风湿性关节炎，动脉粥样硬化新血管形成，牛皮癣，眼新血管形成和肥胖症的2型甲硫氨酸氨肽酶的非肽可逆抑制剂。
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