公开(公告)号：EP2770992A1

公开(公告)日：2014-09-03

申请号：EP12844191.2

申请日：2012-10-25

申请人： Stein, Emily A. ,  Swanson, Christina D. ,  Evans, Michael A. ,  Venkateswara-Rao, Kondapavulur T.

发明人： Stein, Emily A. ,  Swanson, Christina D. ,  Evans, Michael A. ,  Venkateswara-Rao, Kondapavulur T.

IPC分类号： A61K31/401 ,  A61K31/405 ,  A61K31/704 ,  A61P9/02

CPC分类号： A61K31/7048 ,  A61K9/0012 ,  A61K31/401 ,  A61K31/405 ,  A61K31/4166 ,  A61K31/55 ,  A61K33/14 ,  A61K38/1787 ,  A61K45/06 ,  A61M25/0084 ,  A61M25/10 ,  A61M2025/0086 ,  A61M2025/1093 ,  A61K2300/00

摘要： Agents, methods, and devices for affecting nerve function are described. One embodiment of an agent includes a cardiac glycoside, an ACE inhibitor, and an NSAID. The agent may be delivered locally in a site-specific manner to a targeted nerve or portion of a nerve. For example, the agent may be delivered locally to the renal nerves to impair their function and treat hypertension. One embodiment of a delivery device includes one or more needle housings supported by a balloon. A delivery needle is slidably disposed within a needle lumen of each needle housing.

公开(公告)号：EP3246035A1

公开(公告)日：2017-11-22

申请号：EP17154220.2

申请日：2011-01-26

申请人： Evans, Michael A. ,  Venkateswara-Rao, Kondapavulur T. ,  Stein, Emily A.

发明人： Evans, Michael A. ,  Venkateswara-Rao, Kondapavulur T. ,  Stein, Emily A.

IPC分类号： A61K31/7048 ,  A61K31/198 ,  A61K31/55 ,  A61K45/06 ,  A61M25/06 ,  A61M25/00 ,  A61K39/00 ,  A61P9/12

CPC分类号： A61M25/0084 ,  A61B5/0215 ,  A61B5/4094 ,  A61B5/4839 ,  A61B2017/22054 ,  A61B2017/22061 ,  A61B2017/22067 ,  A61B2090/378 ,  A61B2090/3784 ,  A61K31/198 ,  A61K31/55 ,  A61K31/7048 ,  A61K45/06 ,  A61M25/04 ,  A61M2025/0086 ,  A61M2025/0087 ,  A61M2025/1047 ,  A61K2300/00

摘要： Various delivery devices are described to deliver an agent locally to the renal nerves. The delivery devices are positioned in the renal artery and penetrate into the wall of the renal artery to deliver the agent to the renal nerves. The delivery devices may be used to deliver the agent according to longitudinal position, radial position, and depth of the renal nerves relative to the renal artery. In addition, various methods are described to denervate, modulate, or otherwise affect the renal nerves and other neural tissue. Also, various agents are described to denerve, modulate, or otherwise affect the renal nerves and other neural tissue.

摘要翻译： 描述了各种递送装置以将药剂局部递送至肾神经。 输送装置位于肾动脉中并渗入肾动脉的壁中以将药剂递送至肾神经。 递送装置可以用于根据肾神经相对于肾动脉的纵向位置，径向位置和深度递送药剂。 另外，描述了各种方法去除神经，调节或以其他方式影响肾神经和其他神经组织。 而且，描述了各种试剂去神经，调节或以其他方式影响肾神经和其他神经组织。

公开(公告)号：EP2528649A1

公开(公告)日：2012-12-05

申请号：EP11703963.6

申请日：2011-01-26

申请人： Evans, Michael A. ,  Venkateswara-Rao, Kondapavulur T. ,  Stein, Emily A.

发明人： Evans, Michael A. ,  Venkateswara-Rao, Kondapavulur T. ,  Stein, Emily A.

IPC分类号： A61M25/06 ,  A61M25/00

CPC分类号： A61M25/0084 ,  A61B5/0215 ,  A61B5/4094 ,  A61B5/4839 ,  A61B2017/22054 ,  A61B2017/22061 ,  A61B2017/22067 ,  A61B2090/378 ,  A61B2090/3784 ,  A61K31/198 ,  A61K31/55 ,  A61K31/7048 ,  A61K45/06 ,  A61M25/04 ,  A61M2025/0086 ,  A61M2025/0087 ,  A61M2025/1047 ,  A61K2300/00

摘要： Various delivery devices are described to deliver an agent locally to the renal nerves. The delivery devices are positioned in the renal artery and penetrate into the wall of the renal artery to deliver the agent to the renal nerves. The delivery devices may be used to deliver the agent according to longitudinal position, radial position, and depth of the renal nerves relative to the renal artery. In addition, various methods are described to denervate, modulate, or otherwise affect the renal nerves and other neural tissue. Also, various agents are described to denerve, modulate, or otherwise affect the renal nerves and other neural tissue.

公开(公告)号：EP0836430A1

公开(公告)日：1998-04-22

申请号：EP95938830.0

申请日：1995-10-11

申请人： Dubrul, Will R. ,  Evans, Michael A.

发明人： Dubrul, Will R. ,  Evans, Michael A.

IPC分类号： A61B17 ,  A61M29 ,  A61B19 ,  A61F2

CPC分类号： A61M25/104 ,  A61B17/22 ,  A61B17/22012 ,  A61B90/39 ,  A61B2017/22067 ,  A61B2017/22084 ,  A61F2/958 ,  A61M2025/1052 ,  A61M2025/1093

摘要： The present invention describes a catheter (10) suitable for introduction into a tubular tissue for dissolving blockages in such tissue. The catheter (10) is particularly useful for removing thrombi within blood vessels. In accordance with the preferred embodiments, a combination of vibrating motion and injection of a lysing agent is utilized to breakup blockages in vessels. The vessels may be veins, arteries, ducts, intestines, or any lumen within the body that may become blocked from the material that flows through it. As a particular example, dissolution of vascular thrombi is facilitated by advancing a catheter (10) through the occluded vessel, the catheter causing a vibrating, stirring action in and around the thrombus usually in combination with the dispensing of a thrombolytic agent such as urokinase into the thrombus. The catheter (10) has an inflatable or expandable member (59) near the distal tip which, when inflated or expanded, prevents the passage of dislodged thrombus around the catheter. The dislodged portions of thrombus are directed through a perfusion channel in the catheter, where they are removed by filtration means housed within the perfusion channel before the blood exits the tip of the catheter. Catheters that allow both low frequency (1-1000Hz) vibratory motion and delivery of such agents to a blockage, and a method for using such catheters, are disclosed.