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公开(公告)号：EP1986633A2
公开(公告)日：2008-11-05
申请号：EP07705368.4
申请日：2007-02-09
发明人： WYNNE, Graham Michael , WREN, Stephen Paul , JOHNSON, Peter David , PRICE, Paul Damien , DE MOOR, Olivier , NUGENT, Gary , STORER, Richard , PYE, Richard Joseph , DORGAN, Colin Richard
IPC分类号： A61K31/343 , A61K31/404 , A61K31/4184 , A61K31/4192 , A61K31/4196 , A61K31/423 , A61K31/4245 , A61K31/426 , A61K31/4355 , A61K31/4365 , A61K31/437 , A61K31/4439 , A61K31/4525 , A61K31/454 , A61K31/4709
CPC分类号： C07F9/4003 , A61K31/343 , A61K31/404 , A61K31/4184 , A61K31/4192 , A61K31/4196 , A61K31/423 , A61K31/4245 , A61K31/426 , A61K31/4355 , A61K31/4365 , A61K31/437 , A61K31/4439 , A61K31/4525 , A61K31/454 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/517 , A61K31/5377
摘要： There are disclosed compound of Formula (1): A1, A2, A3 and A4 which may be the same or different, represent N or CR1, X is a divalent group selected from O, S(O)n, C=W, NR4, NC(=O)R5 and CR6R7, W is O, S, NR20, Y is N or CR8, one of R4, R5, R6, R8, R9 and NR20 represents - L -R3, in which L is a single bond or a linker group, additionally, R1, R3 - R9, which may be the same or different, independently represent hydrogen or a substituent and R20 represents hydrogen, hydroxyl, alkyl optionally substituted by aryl, alkoxy optionally substituted by aryl, aryl, CN, optionally substituted alkoxy, optionally substituted aryloxy, optionally substitute alkanoyl, optionally substituted aroyl, NO2, NR30R31, in which R30 and R31, which may be the same or different, represent hydrogen, optionally substituted alkyl or optionally substituted aryl; additionally, one of R30 and R31 may represent optionally substituted alkanoyl or optionally substituted aroyl, n represents an integer from 0 to 2, in addition, when an adjacent pair of A1 - A4 each represent CR1, then the adjacent carbon atoms, together with their substituents may form a ring B, when X is CR6R7, R6 and R7, together with the carbon atom to which they are attached may form a ring C, or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for the therapeutic and/or prophylactic treatment of Duchenne muscular dystrophy, Becker muscular dystrophy or cachexia.
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2.发明公开
公开(公告)号：EP2323652A2
公开(公告)日：2011-05-25
申请号：EP09784866.7
申请日：2009-08-04
发明人： WILSON, Francis, Xavier , NASH, Robert, James , HORNE, Graeme , STORER, Richard , TINSLEY, Jonathon, Mark , ROACH, Alan, Geoffrey , DE MOOR, Olivier , MIDDLETON, Penny, Jane , SCHROER, Frank , VAN WELL, Renate , WREN, Stephen, Paul , PASSOS ELEUTERIO, Maria, Ines , DORGAN, Colin, Richard , KAWAMURA, Akane , WYNNE, Graham, Michael
IPC分类号： A61K31/40 , A61K31/445 , A61K31/70 , A61K31/7016 , A61K31/702 , A61P3/00
CPC分类号： A61K31/40 , A61K31/445 , A61K31/70 , A61K31/7016 , A61K31/702
摘要： Described are various compounds, in particular iminosugars, and methods for the treatment of proteostatic diseases, in particular lysosomal storage disorders. The compound may be a pharmacoperone of an enzyme selected from: (a) Acid alpha- glucosidase; (b) Acid beta-glucosidase; (c) glucocerebrosidase; (d) alpha-Galactosidase A; (e) Acid beta-galactosidase; (T) beta-Hexosaminidase A; (g) beta-Hexosaminidase B; (h) Acid sphingomyelinase; (i) Galactocerebrosidase; (j) Acid ceramidase; (k) Arylsulfatase A; (I) alpha-L-lduronidase; (m) lduronate-2-sulfatase; (n) Heparan N-sulfatase; (o) alpha-N- Acetylglucosaminidase; (p) Acetyl-CoA: alpha-glucosaminide N-acetyltransferase; (q) N- Acetylglucosamine-6-sulfate sulfatase; (r) N-Acetylgalactosamine-6-sulfate sulfatase; (s) Acid beta-galactosidase; (t) Arylsulfatase B; (u) beta-Glucuronidase; (v) Acid alpha- mannosidase; (w) Acid beta-mannosidase; (x) Acid alpha-L-fucosidase; (y) Sialidase; and (z) alpha-N-acetylgalactosaminidase.
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公开(公告)号：EP3095783A1
公开(公告)日：2016-11-23
申请号：EP16155561.0
申请日：2009-12-01
发明人： WILSON, Francis Xavier , JOHNSON, Peter David , VICKERS, Richard , STORER, Richard , WYNNE, Graham Michael , ROACH, Alan Geoffrey , DE MOOR, Olivier , DORGAN, Colin Richard , DAVIS, Paul James
IPC分类号： C07D235/18 , C07D401/14 , A61K31/4184 , A61P31/04
CPC分类号： A61K31/444 , A61K31/4439 , C07D235/18 , C07D401/14 , Y02A50/473
摘要： Disclosed are pharmaceutical compositions comprising the compound 2,2'-di(pyridin-4-yl)-1H,1'H-5,5'-bibenzo[d]imidazole, or a pharmaceutically acceptable N-oxide, salt, hydrate or solvate thereof, and a pharmaceutically acceptable excipient. The compositions find application in methods of treating infection with Clostridium difficile and in methods of treating Clostridium difficile -associated disease (CDAD).
摘要翻译： 公开了包含化合物2,2'-二（吡啶-4-基）-1H，1'H-5,5'-联苯并[d]咪唑或其药学上可接受的N-氧化物，盐，水合物或 其溶剂化物和药学上可接受的赋形剂。 该组合物可用于治疗艰难梭菌感染的方法以及治疗艰难梭菌相关疾病（CDAD）的方法中。
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公开(公告)号：EP2373631A2
公开(公告)日：2011-10-12
申请号：EP09795514.0
申请日：2009-12-01
发明人： WILSON, Francis, Xavier , JOHNSON, Peter, David , VICKERS, Richard , STORER, Richard , WYNNE, Graham, Michael , ROACH, Alan, Geoffrey , DE MOOR, Olivier , DORGAN, Colin, Richard , DAVIS, Paul, James
IPC分类号： C07D235/18 , C07D401/14 , A61K31/4184 , A61P31/04
CPC分类号： A61K31/444 , A61K31/4439 , C07D235/18 , C07D401/14 , Y02A50/473
摘要： Disclosed are pharmaceutical compositions comprising the compound 2,2'-di(pyridin-4-yl)-1H,1'H-5,5'-bibenzo[d]imidazole, or a pharmaceutically acceptable N-oxide, salt, hydrate or solvate thereof, and a pharmaceutically acceptable excipient. The compositions find application in methods of treating infection with Clostridium difficile and in methods of treating Clostridium difficile -associated disease (CDAD).
摘要翻译： 公开了包含化合物2,2'-二（吡啶-4-基）-1H，1'H-5,5'-联苯并[d]咪唑或其药学上可接受的N-氧化物，盐，水合物或 其溶剂化物和药学上可接受的赋形剂。 该组合物可应用于治疗艰难梭菌感染的方法和治疗难辨梭状芽孢杆菌相关疾病（CDAD）的方法。
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5.发明授权
公开(公告)号：EP2170396B1
公开(公告)日：2016-12-21
申请号：EP08788620.6
申请日：2008-08-01
发明人： WYNNE, Graham Michael , WREN, Stephen Paul , JOHNSON, Peter David , PRICE, Paul Damien , DE MOOR, Olivier , NUGENT, Gary , STORER, Richard , PYE, Richard Joseph , DORGAN, Colin Richard , TINSLEY, Jonathon Mark
IPC分类号： A61K31/423 , A61K31/573
CPC分类号： A61K31/573 , A61K31/423 , A61K45/06 , C07D263/58 , A61K2300/00
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公开(公告)号：EP1986633B1
公开(公告)日：2014-07-30
申请号：EP07705368.4
申请日：2007-02-09
发明人： WYNNE, Graham Michael , WREN, Stephen Paul , JOHNSON, Peter David , PRICE, Paul Damien , DE MOOR, Olivier , NUGENT, Gary , STORER, Richard , PYE, Richard Joseph , DORGAN, Colin Richard
IPC分类号： A61K31/343 , A61K31/404 , A61K31/4184 , A61K31/4192 , A61K31/4196 , A61K31/423 , A61K31/4245 , A61K31/426 , A61K31/4355 , A61K31/4365 , A61K31/437 , A61K31/4439 , A61K31/4525 , A61K31/454 , A61K31/4709 , A61P21/00
CPC分类号： C07F9/4003 , A61K31/343 , A61K31/404 , A61K31/4184 , A61K31/4192 , A61K31/4196 , A61K31/423 , A61K31/4245 , A61K31/426 , A61K31/4355 , A61K31/4365 , A61K31/437 , A61K31/4439 , A61K31/4525 , A61K31/454 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/517 , A61K31/5377
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公开(公告)号：EP2373631B1
公开(公告)日：2015-02-25
申请号：EP09795514.0
申请日：2009-12-01
发明人： WILSON, Francis, Xavier , JOHNSON, Peter, David , VICKERS, Richard , STORER, Richard , WYNNE, Graham, Michael , ROACH, Alan, Geoffrey , DE MOOR, Olivier , DORGAN, Colin, Richard , DAVIS, Paul, James
IPC分类号： C07D235/18 , C07D401/14 , A61K31/4184 , A61P31/04
CPC分类号： A61K31/444 , A61K31/4439 , C07D235/18 , C07D401/14 , Y02A50/473
摘要： Disclosed are pharmaceutical compositions comprising the compound 2,2'-di(pyridin-4-yl)-1H,1'H-5,5'-bibenzo[d]imidazole, or a pharmaceutically acceptable N-oxide, salt, hydrate or solvate thereof, and a pharmaceutically acceptable excipient. The compositions find application in methods of treating infection with Clostridium difficile and in methods of treating Clostridium difficile -associated disease (CDAD).
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公开(公告)号：EP2323651A2
公开(公告)日：2011-05-25
申请号：EP09784865.9
申请日：2009-08-04
发明人： WILSON, Francis, Xavier , NASH, Robert, James , HORNE, Graeme , STORER, Richard , TINSLEY, Jonathan, Mark , ROACH, Alan, Geoffrey , MIDDLETON, Penny, Jane , DE MOOR, Olivier , VAN WELL, Renate , PASSOS ELEUTERIO, Maria, Ines , SCHROER, Frank , WREN, Stephen, Paul , DORGAN, Colin, Richard , WYNNE, Graham, Michael , KAWAMURA, Akane
IPC分类号： A61K31/40 , A61K31/445 , A61K31/70 , A61K31/7016 , A61K31/702 , A61P31/12
CPC分类号： C07H19/16 , A61K31/40 , A61K31/445 , A61K31/70 , A61K31/7016 , A61K31/702
摘要： Described are various compounds and methods for the treatment of flaviviral infections. In particular, alkaloids and imino sugars in arabinose and/or lyxose stereochemical configuration with antiflaviviral activity are described.
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公开(公告)号：EP2173346A2
公开(公告)日：2010-04-14
申请号：EP08762457.3
申请日：2008-06-24
IPC分类号： A61K31/4706 , C07D405/12 , C07D471/04
CPC分类号： C07D239/95 , C07D401/04 , C07D403/04 , C07D405/12 , C07D409/12 , C07D471/04
摘要： Compounds of a compound of compound of general formula (I) wherein X1, X2, A, R1 R2, R3 and R4 are as defined herein; are useful as anti-mycobacterial agents, especially agents for the treatment of tuberculosis.
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公开(公告)号：EP2170325A2
公开(公告)日：2010-04-07
申请号：EP08788621.4
申请日：2008-08-01
发明人： WYNNE, Graham Michael , WREN, Stephen Paul , JOHNSON, Peter David , PRICE, Paul Damien , DE MOOR, Olivier , NUGENT, Gary , STORER, Richard , PYE, Richard Joseph , DORGAN, Colin Richard
IPC分类号： A61K31/4192 , A61K31/416 , A61K45/00 , A61P21/00
CPC分类号： A61K45/06 , A61K31/416 , A61K31/4192 , A61K2300/00
摘要： Combinations comprising (or consisting essentially of) one or more compounds of the formula (I) or (II) with one or more ancillary compounds, to processes for preparing the combinations, and to various therapeutic uses of the combinations. Also provided are pharmaceutical compositions containing the combinations as well as a method of treatment of Duchenne muscular dystrophy, Becker muscular dystrophy or cachexia using the combinations.
摘要翻译： 包含一种或多种式（I）或（II）化合物与一种或多种辅助化合物（或基本上由其组成）的组合，用于制备组合的方法以及组合的各种治疗用途。 还提供了含有所述组合的药物组合物以及使用所述组合治疗杜氏肌营养不良，贝克肌营养不良或恶病质的方法。
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