公开(公告)号：EP1978961B1

公开(公告)日：2016-03-16

申请号：EP06848050.8

申请日：2006-12-21

申请人： Sunovion Pharmaceuticals Inc.

发明人： SHAO, Liming ,  WANG, Fengjiang ,  MALCOLM, Scott, Christopher ,  HEWITT, Michael, Charles ,  BUSH, Larry, R. ,  VARNEY, Mark ,  CAMPBELL, Una ,  ENGEL, Sharon, Rae ,  HARDY, Larry, Wendell ,  KOCH, Patrick ,  MA, Jianguo

IPC分类号： C07D215/12 ,  C07C211/30 ,  C07C211/40 ,  C07C215/44 ,  C07C217/74 ,  A01N43/42 ,  A61K31/47

CPC分类号： C07C211/40 ,  C07C17/16 ,  C07C17/35 ,  C07C45/38 ,  C07C45/52 ,  C07C45/63 ,  C07C45/67 ,  C07C45/68 ,  C07C45/74 ,  C07C211/29 ,  C07C211/30 ,  C07C211/42 ,  C07C215/44 ,  C07C217/74 ,  C07C2601/14 ,  C07C2602/10 ,  C07D215/12 ,  C07C25/22 ,  C07C22/04 ,  C07C47/453 ,  C07C49/67 ,  C07C49/697 ,  C07C49/255 ,  C07C49/755 ,  C07C49/683

公开(公告)号：EP1904066B1

公开(公告)日：2018-05-23

申请号：EP06786496.7

申请日：2006-07-06

申请人： Sunovion Pharmaceuticals Inc.

发明人： CARON, Judy ,  WESSEL, Thomas ,  LALJI, Karim ,  VARNEY, Mark ,  BAKALE, Roger P. ,  SINGH, Surendra P. ,  WILKINSON, H. Scott ,  SU, Xiping ,  HAN, Zhengxu ,  KOENIG, Stephan G.

IPC分类号： A61K31/135 ,  A61K31/4985 ,  C07C211/42 ,  A61P25/24 ,  A61P25/28 ,  A61P25/00

CPC分类号： A61K31/4985 ,  A61K31/135 ,  C07C211/42 ,  C07C2602/10 ,  A61K2300/00

摘要： One aspect of the present invention relates to pharmaceutical compositions containing two or more active agents that when taken together can be used to treat, e.g., menopause, mood disorders, anxiety disorders, or cognitive disorders. The first component of the pharmaceutical composition is a sedative eszopiclone. The second component of the pharmaceutical composition is trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro- N -methyl-1-napthalenamine or trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine. The present invention also relates to a method of treating menopause, perimenopause, mood disorders, anxiety disorders, and cognitive disorders.