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公开(公告)号：EP2407466A4
公开(公告)日：2012-09-05
申请号：EP10750777
申请日：2010-03-08
IPC分类号： C07D401/12 , A61K31/496 , A61K31/5377 , A61P1/04 , A61P3/04 , A61P7/04 , A61P9/00 , A61P11/00 , A61P11/06 , A61P15/00 , A61P15/06 , A61P15/08 , A61P17/00 , A61P17/04 , A61P17/06 , A61P17/10 , A61P19/02 , A61P21/00 , A61P21/04 , A61P25/00
CPC分类号： C07D401/14 , A61K31/496 , A61K31/5377 , C07D207/34 , C07D213/81 , C07D277/82 , C07D401/12 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/12 , C07D413/12 , C07D413/14
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公开(公告)号：EP2527340A4
公开(公告)日：2013-07-03
申请号：EP11734668
申请日：2011-01-19
IPC分类号： C07D401/14 , A61K31/496 , A61K31/5377 , A61P3/04 , A61P7/04 , A61P9/10 , A61P11/02 , A61P11/06 , A61P15/08 , A61P17/00 , A61P17/04 , A61P17/10 , A61P19/02 , A61P21/00 , A61P25/04
CPC分类号： C07D403/14 , A61K31/496 , A61K31/5377 , C07D211/58 , C07D213/81 , C07D277/82 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D413/12
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公开(公告)号：EP2615084A4
公开(公告)日：2014-04-09
申请号：EP11823544
申请日：2011-09-06
IPC分类号： C07D211/16 , A61K31/445 , A61K31/4545 , A61K31/4709 , A61K31/506 , A61K31/5377 , A61P11/06 , A61P29/00 , A61P37/08 , A61P43/00 , C07D211/58 , C07D401/06 , C07D401/12 , C07D401/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14
CPC分类号： C07D211/16 , C07D211/58 , C07D401/06 , C07D401/12 , C07D401/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14
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4.发明公开
公开(公告)号：EP1911755A4
公开(公告)日：2009-06-17
申请号：EP06780997
申请日：2006-07-12
IPC分类号： C07D401/14 , A61K31/4184 , A61K31/422 , A61K31/428 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/501 , A61K31/5377 , A61P25/28 , A61P29/00 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D413/14 , C07D417/14
CPC分类号： C07D405/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14
摘要： A benzoimidazole compound represented by the general formula (I) or a salt thereof: (I) wherein X1 represents an oxygen atom or a carbonyl group; and R1 represents a furan ring having 1 to 3 substituents or a pyrrole ring which may have 1 to 3 substituents, provided that a compound represented by the general formula (I) wherein the substituent is a phosphoric acid group or a phosphate ester group is excluded. The benzoimidazole compound or salt thereof has an excellent prostaglandin D synthetase inhibitory activity, and is useful as a prophylactic and/or therapeutic agent for a disease associated with prostaglandin D2 or a metabolite thereof, such as an allergic disease or an inflammatory disease or as an inhibitor for the exacerbation of Alzheimer disease or cerebral damage.
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