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1.发明公开EFFECT OF TREATMENT WITH 4,5-DIHYDROXY- 2-CYCLOPENTEN-1-ONE (DHCP) ON GENE EXPRESSION AND QUORUM-SENSING IN BACTERIA 有权治疗与4,5-二羟基-2-环戊烯-1-酮（DHCP）对基因表达和仲裁测量中的细菌的影响
公开(公告)号：EP1482793A4
公开(公告)日：2005-07-27
申请号：EP03713993
申请日：2003-03-07
申请人： TAKARA BIO INC
IPC分类号： C12N15/09 , C12N1/00 , C12N1/20 , C12P21/02 , C12Q1/02 , C12Q1/68 , A01N37/18 , C07H21/02 , C07K1/00
CPC分类号： C12P21/00 , C12Q1/6837 , C12Q1/689 , C12Q2600/158
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2.发明公开COLD SHOCK INDUCIBLE EXPRESSION AND PRODUCTION OF HETEROLOGOUS POLYPEPTIDES 审中-公开KÄLTESCHOCKINDUZIERBARE表达和生产异源多肽
公开(公告)号：EP1478733A4
公开(公告)日：2005-08-10
申请号：EP03743693
申请日：2003-02-25
申请人： TAKARA BIO INC
发明人： INOUYE MASAYORI , PHADTARE SANGITA , XIA BING , QING GUOLIANG , KE HAIPING
IPC分类号： C12N15/09 , C07H21/04 , C07K14/47 , C12N1/15 , C12N1/21 , C12N15/63 , C12N15/67 , C12N15/70 , C12P21/02 , C12P21/06 , C12Q1/00 , C12N5/10 , G01V3/14
CPC分类号： C12N15/67 , C07K2299/00 , C12N15/70 , Y10T436/24
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3.发明公开GENE CONFERRING RESISTANCE TO THE ANTIBACTERIAL 4,5-DIHYDROXY-2-CYCLOPENTEN-1-ONE (DHCP), THE PROTEIN ENCODED BY SAME, AND APPLICATIONS THEREOF 有权GEN，于抗细菌性的4,5-二羟基-2-环戊烯-1-酮（DHCP）促进，THE SO CODED蛋白及其用途
公开(公告)号：EP1313458A4
公开(公告)日：2004-10-13
申请号：EP01964501
申请日：2001-08-29
申请人： TAKARA BIO INC
CPC分类号： C07K14/245
摘要： The invention relates to a gene isolated from E. coli, dep, which confers resistance to the antibacterial activity of 4,5-dihydroxy-2-cyclopenten-1-one (DHCP). The invention further relates to the putative protein encoded by dep, which is a hydrophobic, transmembrane efflux protein specific for DHCP. The invention further relates to plasmids containing the dep gene, and to bacterial cells expressing dep. Furthermore, the invention provides applications for use in conferring resistance to antibacterial activity in organisms. The dep gene can be used to identify compounds which inhibit the efflux activity responsible for the resistance to DHCP or to compounds which are functionally equivalent to DHCP.
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