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公开(公告)号：EP1111065A2
公开(公告)日：2001-06-27
申请号：EP00204658.9
申请日：1993-11-25
CPC分类号： C07H3/04 , C07H3/06 , C07H7/033 , C07H15/04 , C07H15/22 , C07H15/24 , C07H15/256 , C08B30/18 , C08B31/18 , C08B37/0012 , C08B37/0021 , C12P19/02 , C12P19/04 , C12P19/12 , C12P19/56 , Y10S435/822
摘要： A process for producing a saccharide carboxylic acid or a salt thereof is characterised in that a microorganism belonging to the genus Pseudogluconobacter and capable of oxidizing a hydroxymethyl group and/or hemiacetal hydroxyl-associated carbon atom to a carboxyl group, or an artefact derived from the microorganism, is permitted to act on a hydroxymethyl and/or hemiacetal hydroxyl-containing saccharide or saccharide derivative to produce and accumulate the corresponding carboxylic acid, and the carboxylic acid so accumulated is harvested; novel saccharide carboxylic acids produced by the above production method, and by the process, from a broad range of saccharides, saccharic acids having carboxyl groups derived from hydroxymethyl and/or hemiacetal OH groups can be produced with high selectivity and in good yield; the resultant saccharide acids are resistant to enzymatic degradation and have improved water solubility, among other characteristics.
摘要翻译： 糖羧酸或其盐的制造方法的特征在于，属于假葡糖杆菌属的能够将羟甲基和/或半缩醛羟基相关碳原子氧化成羧基的微生物或衍生自 微生物被允许作用于羟甲基和/或半缩醛羟基的糖或糖衍生物以产生并累积相应的羧酸，并收集如此积累的羧酸; 通过上述制备方法制备的新型糖类羧酸，并且通过该方法可以从高范围的糖类获得具有羟基甲基和/或半缩醛OH基团的具有羧基的糖酸，并且以高的选择性和良好的收率生产; 所产生的糖酸对酶降解具有抗性，并具有改善的水溶性等特性。
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公开(公告)号：EP0599646A2
公开(公告)日：1994-06-01
申请号：EP93309412.0
申请日：1993-11-25
IPC分类号： C12P19/02 , C12P19/56 , C12P19/04 , C12P19/12 , C07H15/24 , C08B37/16 , C08B31/18 , C08B37/02 , C12P19/00
CPC分类号： C07H3/04 , C07H3/06 , C07H7/033 , C07H15/04 , C07H15/22 , C07H15/24 , C07H15/256 , C08B30/18 , C08B31/18 , C08B37/0012 , C08B37/0021 , C12P19/02 , C12P19/04 , C12P19/12 , C12P19/56 , Y10S435/822
摘要： A process for producing a saccharide carboxylic acid or a salt thereof is characterised in that a microorganism belonging to the genus Pseudogluconobacter and capable of oxidizing a hydroxymethyl group and/or hemiacetal hydroxyl-associated carbon atom to a carboxyl group, or an artefact derived from the microorganism, is permitted to act on a hydroxymethyl and/or hemiacetal hydroxyl-containing saccharide or saccharide derivative to produce and accumulate the corresponding carboxylic acid, and the carboxylic acid so accumulated is harvested; novel saccharide carboxylic acids produced by the above production method, and by the process, from a broad range of saccharides, saccharic acids having carboxyl groups derived from hydroxymethyl and/or hemiacetal OH groups can be produced with high selectivity and in good yield; the resultant saccharide acids are resistant to enzymatic degradation and have improved water solubility, among other characteristics.
摘要翻译： 糖羧酸或其盐的制造方法的特征在于，属于假葡糖杆菌属的能够将羟甲基和/或半缩醛羟基相关碳原子氧化成羧基的微生物或衍生自 微生物被允许作用于羟甲基和/或半缩醛羟基的糖或糖衍生物以产生并累积相应的羧酸，并收集如此积累的羧酸; 通过上述制备方法制备的新型糖类羧酸，并且通过该方法可以从高范围的糖类获得具有羟基甲基和/或半缩醛OH基团的具有羧基的糖酸，并且以高的选择性和良好的收率生产; 所产生的糖酸对酶降解具有抗性，并具有改善的水溶性等特性。
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3.发明公开1-Azaxanthone-3-carboxylic acids, their preparation and pharmaceutical compositions containing them 失效1-Azaxanthon -3-羧酸，它们的制备和含有它们的药物组合物。
公开(公告)号：EP0026675A1
公开(公告)日：1981-04-08
申请号：EP80303461.0
申请日：1980-10-01
IPC分类号： C07D491/04 , A61K31/44
CPC分类号： C07D491/04 , C07F9/6561
摘要： Novel 1-azaxanthone-3-carboxylic acid derivatives, which are shown by the following formula (I)
wherein R is hydrogen, alkyl, alkoxy or halogen; R, and R 2 are the same or different and each is hydrogen, alkyl or alkenyl; and m is 1 or 2; and their physiologically acceptable salts, are usable as effective medicines for preventing and/ or treating allergic diseases. The compound of the formula (I) can be produced by reacting a compound of the formula:
wherein R and m have the same meaning as defined above; R 3 is carboxyl or group which is convertible into carboxyl through hydrolysis; X is alkyl phosphate radical or halogen, with a compound of the formula:
wherein R, and R 2 have the same meaning as defined above, or its salt, and conducting hydrolysis, if necessary.-
公开(公告)号：EP1111065A3
公开(公告)日：2002-01-02
申请号：EP00204658.9
申请日：1993-11-25
IPC分类号： C12P19/02 , C12P19/56 , C12P19/04 , C12P19/12 , C07H15/24 , C08B37/16 , C08B31/18 , C08B37/02 , C12P19/00
CPC分类号： C07H3/04 , C07H3/06 , C07H7/033 , C07H15/04 , C07H15/22 , C07H15/24 , C07H15/256 , C08B30/18 , C08B31/18 , C08B37/0012 , C08B37/0021 , C12P19/02 , C12P19/04 , C12P19/12 , C12P19/56 , Y10S435/822
摘要： A process for producing a saccharide carboxylic acid or a salt thereof is characterised in that a microorganism belonging to the genusPseudogluconobacter and capable of oxidizing a hydroxymethyl group and/or hemiacetal hydroxyl-associated carbon atom to a carboxyl group, or an artefact derived from the microorganism, is permitted to act on a hydroxymethyl and/or hemiacetal hydroxyl-containing saccharide or saccharide derivative to produce and accumulate the corresponding carboxylic acid, and the carboxylic acid so accumulated is harvested; novel saccharide carboxylic acids produced by the above production method, and by the process, from a broad range of saccharides, saccharic acids having carboxyl groups derived from hydroxymethyl and/or hemiacetal OH groups can be produced with high selectivity and in good yield; the resultant saccharide acids are resistant to enzymatic degradation and have improved water solubility, among other characteristics.
摘要翻译： 生产糖羧酸或其盐的方法的特征在于，属于假葡糖杆菌属并能够将羟甲基和/或半缩醛羟基相关的碳原子氧化成羧基的微生物或源自该微生物的赝物 允许作用于含有羟甲基和/或半缩醛羟基的糖或糖衍生物以产生和积聚相应的羧酸，并且收集如此积累的羧酸; 通过上述制造方法制造的新型糖类羧酸可以以高选择率且高收率地制造来自广范围的糖类的具有来自羟甲基和/或半缩醛OH基的羧基的糖酸类， 所得糖酸对酶降解具有抗性，并具有改善的水溶性等特征。
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5.发明授权1-Azaxanthone-3-carboxylic acids, their preparation and pharmaceutical compositions containing them 失效1-AZAXANTHONE-3-CARBOXYLIC ACID，它们的制备和药物组合物
公开(公告)号：EP0026675B1
公开(公告)日：1984-03-14
申请号：EP80303461.0
申请日：1980-10-01
IPC分类号： C07D491/04 , A61K31/44
CPC分类号： C07D491/04 , C07F9/6561
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公开(公告)号：EP0599646B1
公开(公告)日：2002-09-18
申请号：EP93309412.0
申请日：1993-11-25
IPC分类号： C12P19/02 , C12P19/56 , C12P19/04 , C12P19/12 , C07H15/24 , C08B37/16 , C08B31/18 , C08B37/02 , C12P19/00
CPC分类号： C07H3/04 , C07H3/06 , C07H7/033 , C07H15/04 , C07H15/22 , C07H15/24 , C07H15/256 , C08B30/18 , C08B31/18 , C08B37/0012 , C08B37/0021 , C12P19/02 , C12P19/04 , C12P19/12 , C12P19/56 , Y10S435/822
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公开(公告)号：EP0599646A3
公开(公告)日：1995-04-19
申请号：EP93309412.0
申请日：1993-11-25
IPC分类号： C12P19/02 , C12P19/56 , C12P19/04 , C12P19/12 , C07H15/24 , C08B37/16 , C08B31/18 , C08B37/02 , C12P19/00
CPC分类号： C07H3/04 , C07H3/06 , C07H7/033 , C07H15/04 , C07H15/22 , C07H15/24 , C07H15/256 , C08B30/18 , C08B31/18 , C08B37/0012 , C08B37/0021 , C12P19/02 , C12P19/04 , C12P19/12 , C12P19/56 , Y10S435/822
摘要： A process for producing a saccharide carboxylic acid or a salt thereof is characterised in that a microorganism belonging to the genus Pseudogluconobacter and capable of oxidizing a hydroxymethyl group and/or hemiacetal hydroxyl-associated carbon atom to a carboxyl group, or an artefact derived from the microorganism, is permitted to act on a hydroxymethyl and/or hemiacetal hydroxyl-containing saccharide or saccharide derivative to produce and accumulate the corresponding carboxylic acid, and the carboxylic acid so accumulated is harvested; novel saccharide carboxylic acids produced by the above production method, and by the process, from a broad range of saccharides, saccharic acids having carboxyl groups derived from hydroxymethyl and/or hemiacetal OH groups can be produced with high selectivity and in good yield; the resultant saccharide acids are resistant to enzymatic degradation and have improved water solubility, among other characteristics.
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8.发明公开
公开(公告)号：EP0634174A1
公开(公告)日：1995-01-18
申请号：EP94305093.0
申请日：1994-07-12
CPC分类号： A61K31/715
摘要： An antianemic composition for veterinary use which comprises a complex of a dextran carboxylic acid obtained by a microbial process and an iron salt, and a veterinary acceptable carrier is disclosed. The composition can contain a high concentration of iron and have a low viscosity and particularly useful for preventing or treating anemia of piglets caused by iron deficiency.
摘要翻译： 公开了包含通过微生物过程获得的葡聚糖羧酸与铁盐的络合物和兽医学可接受的载体的用于兽医用途的抗老剂组合物。 该组合物可含有高浓度的铁并且具有低粘度，特别可用于预防或治疗由缺铁导致的仔猪的贫血。
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