OXIDIZED -1,4-OLIGOGLUCURONIC ACID, AND PREPARATION METHOD THEREFOR AND USES THEREOF
    3.
    发明公开
    OXIDIZED -1,4-OLIGOGLUCURONIC ACID, AND PREPARATION METHOD THEREFOR AND USES THEREOF 审中-公开
    氧化-1,4-低聚古洛糖酸及其制备方法及其用途

    公开(公告)号:EP3299395A1

    公开(公告)日:2018-03-28

    申请号:EP16799270.0

    申请日:2016-05-20

    Abstract: The present invention relates to the technical field of medical compounds, and relates to an oxidized α-1,4-oligoglucuronic acid, and a preparation method therefor and uses thereof. In the present invention, by using abundant starch, especially soluble starch, in the natural world as the raw material, all 6-site hydroxyl groups of the starch α-1,4-polyglucose are oxidized into carboxyl groups to form glucuronic acid under the action of a sodium bromide (NaBr)-2,2,6,6-tetramethyl piperidine oxide (TEMPO)-sodium hypochlorite (NaClO) oxidation system, and the oxidized oligoglucuronic acid having an open ring at an end is prepared by controlling reaction conditions. The compound has obvious anti-cerebral ischemia activity, and can be developed into a potential anti-cerebral ischemia drug.

    Abstract translation: 本发明涉及医药化合物技术领域,涉及一种氧化型α-1,4-低聚葡糖醛酸及其制备方法和用途。 在本发明中,通过在自然界中使用大量的淀粉,特别是可溶性淀粉作为原料,淀粉α-1,4-聚葡萄糖中的所有6位羟基都被氧化成羧基,形成葡萄糖醛酸 溴化钠(NaBr)-2,2,6,6-四甲基哌啶氧化物(TEMPO) - 次氯酸钠(NaClO)氧化体系和最终具有开环的氧化低聚葡糖醛酸的作用通过控制反应条件 。 该化合物具有明显的抗脑缺血活性,可开发成潜在的抗脑缺血药物。

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