公开(公告)号：EP1454982A4

公开(公告)日：2005-12-28

申请号：EP02786101

申请日：2002-12-13

申请人： TAKEDA PHARMACEUTICAL

发明人： HINUMA SHUJI ,  KOBAYASHI MAKOTO ,  ARAI TOSHIMITSU ,  FUKUSUMI SHOJI ,  FUJII RYO ,  KOMATSU HIDETOSHI ,  MATSUMURA FUMIKA ,  KAWAMATA YUJI ,  OGI KAZUHIRO

IPC分类号： A61K38/17 ,  A61P35/00 ,  C07K14/47 ,  C07K14/705 ,  C12Q1/68 ,  G01N33/566 ,  G01N33/68 ,  C12N15/00 ,  A61P43/00 ,  C07K16/18 ,  C12P21/02 ,  G01N33/15 ,  G01N33/50

CPC分类号： A61K38/1709 ,  C07K14/4726 ,  C07K14/705 ,  C12Q1/6886 ,  C12Q2600/136 ,  G01N33/566 ,  G01N33/689 ,  G01N2333/705 ,  G01N2333/726

摘要： It is intended to provide a method of analyzing gene expression, a novel use of a receptor protein, etc. More specifically speaking, a method of analyzing gene expression characterized by comprising qualitatively analyzing the individual expression doses of a plural number of genes and thus identifying a gene showing characteristic promotion or inhibition in its expression in specific cells or tissue; a quantification kit to be used in this method; and so on. Moreover, a method of screening a compound or its salt capable of changing the binding properties of a receptor protein, which is a novel G protein-coupled receptor protein having an amino acid sequence being identical or substantially identical with the amino acid sequence represented by SEQ ID NO:9, or its salt to ligands characterized by using the above protein or its salt and a protein (for example, a lectin) showing an affinity for a sugar chain which is one of the ligands is provided.

公开(公告)号：EP1941909A4

公开(公告)日：2012-05-23

申请号：EP06822164

申请日：2006-10-24

申请人： TAKEDA PHARMACEUTICAL

发明人： ARAI TOSHIMITSU ,  TANIYAMA YOSHIO ,  KOKUBO TOSHIO

IPC分类号： A61K45/00 ,  A61K31/7105 ,  A61K38/00 ,  A61K39/395 ,  A61P13/08 ,  A61P13/10 ,  A61P35/00 ,  A61P35/02 ,  A61P35/04 ,  A61P43/00 ,  C07K16/22 ,  C07K16/28

CPC分类号： A61K39/39558 ,  A61K31/7105 ,  C07K16/22 ,  C07K16/2863 ,  C07K2317/73

公开(公告)号：EP1923072A4

公开(公告)日：2010-03-03

申请号：EP06782749

申请日：2006-08-09

申请人： TAKEDA PHARMACEUTICAL

发明人： KONDO SHINICHI ,  SUNAHARA EIJI ,  ARAI TOSHIMITSU ,  UTSUMI HIROKO

IPC分类号： A61K39/395 ,  A61K31/7088 ,  A61K45/00 ,  A61K48/00 ,  A61P35/00 ,  C07K16/30

CPC分类号： C07K16/30 ,  A61K31/7088 ,  A61K2039/505 ,  C07K16/28 ,  C07K16/3015 ,  C07K16/3023 ,  C07K16/3046 ,  C12N15/1135 ,  C12N2310/11

公开(公告)号：EP1457556A4

公开(公告)日：2005-01-19

申请号：EP02790932

申请日：2002-12-27

申请人： TAKEDA PHARMACEUTICAL

发明人： KOBAYASHI MAKOTO ,  ARAI TOSHIMITSU ,  MATSUMURA FUMIKA

IPC分类号： A61P43/00 ,  C12Q1/68 ,  G01N33/53 ,  C12N15/09 ,  A61K39/395 ,  A61K45/00 ,  A61K48/00 ,  G01N33/566

CPC分类号： G01N33/5308 ,  C12Q1/6813 ,  C12Q1/6851 ,  C12Q2545/101 ,  C12Q2561/101

摘要： It is intended to provide a method of quantifying a nucleic acid and a kit for quantifying a nucleic acid. More specifically, it is intended to provide a standard comprising a synthetic polynucleotide obtained by chemical synthesis which is to be used for forming a calibration curve employed for quantifying a specific target nucleic acid in a sample, a quantification method and a quantification kit using the same, a method of diagnosing a specific disease, etc. The standard is a synthetic polynucleotide obtained by chemical synthesis. Compared with the existing standards comprising biosynthesized polynucleotides, it has an advantage that a target sequence can be precisely obtained by a convenient method. Moreover, the above-described standard suffers from little biological contamination. Therefore, it is highly safe to the environment and factors disturbing highly precise quantification can be lessened therein.