公开(公告)号：EP1454982A4

公开(公告)日：2005-12-28

申请号：EP02786101

申请日：2002-12-13

申请人： TAKEDA PHARMACEUTICAL

发明人： HINUMA SHUJI ,  KOBAYASHI MAKOTO ,  ARAI TOSHIMITSU ,  FUKUSUMI SHOJI ,  FUJII RYO ,  KOMATSU HIDETOSHI ,  MATSUMURA FUMIKA ,  KAWAMATA YUJI ,  OGI KAZUHIRO

IPC分类号： A61K38/17 ,  A61P35/00 ,  C07K14/47 ,  C07K14/705 ,  C12Q1/68 ,  G01N33/566 ,  G01N33/68 ,  C12N15/00 ,  A61P43/00 ,  C07K16/18 ,  C12P21/02 ,  G01N33/15 ,  G01N33/50

CPC分类号： A61K38/1709 ,  C07K14/4726 ,  C07K14/705 ,  C12Q1/6886 ,  C12Q2600/136 ,  G01N33/566 ,  G01N33/689 ,  G01N2333/705 ,  G01N2333/726

摘要： It is intended to provide a method of analyzing gene expression, a novel use of a receptor protein, etc. More specifically speaking, a method of analyzing gene expression characterized by comprising qualitatively analyzing the individual expression doses of a plural number of genes and thus identifying a gene showing characteristic promotion or inhibition in its expression in specific cells or tissue; a quantification kit to be used in this method; and so on. Moreover, a method of screening a compound or its salt capable of changing the binding properties of a receptor protein, which is a novel G protein-coupled receptor protein having an amino acid sequence being identical or substantially identical with the amino acid sequence represented by SEQ ID NO:9, or its salt to ligands characterized by using the above protein or its salt and a protein (for example, a lectin) showing an affinity for a sugar chain which is one of the ligands is provided.

公开(公告)号：EP1477806A4

公开(公告)日：2006-09-06

申请号：EP03706989

申请日：2003-02-21

申请人： TAKEDA PHARMACEUTICAL

发明人： HINUMA SHUJI ,  FUJII RYO ,  OGI KAZUHIRO ,  KOMATSU HIDETOSHI ,  KAWAMATA YUJI ,  HOSOYA MASAKI

IPC分类号： C07K14/705 ,  C07K14/72 ,  G01N33/566 ,  G01N33/58 ,  G01N33/74 ,  G01N33/92 ,  G01N33/50 ,  C07K16/28 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12P21/02 ,  C12Q1/68 ,  G01N33/15

CPC分类号： G01N33/582 ,  G01N33/566 ,  G01N2333/726

摘要： It is intended to provide a method of determining a ligand to an orphan receptor. More specifically speaking, it is intended to provide a method of a ligand to a receptor protein, to which no ligand has been determined, characterized by using a fused protein of the receptor protein with a fluorescent protein.

公开(公告)号：EP1860185A4

公开(公告)日：2009-08-12

申请号：EP06729848

申请日：2006-03-17

申请人： TAKEDA PHARMACEUTICAL

发明人： KOMATSU HIDETOSHI ,  ITOH YASUAKI ,  MORI MASAAKI ,  MARUYAMA MINORU

IPC分类号： C12N15/09 ,  A61K45/00 ,  A61P25/16 ,  A61P25/28 ,  C07K14/705 ,  C12Q1/02 ,  G01N33/15 ,  G01N33/50

CPC分类号： G01N33/68 ,  G01N33/5008 ,  G01N33/5011 ,  G01N33/5041 ,  G01N2500/00 ,  G01N2800/2814

摘要： Disclosed are a compound capable of promoting or inhibiting the activity of a protein having the same or substantially the same amino acid sequence as that depicted in SEQ ID NO:1 or a salt of the compound; a compound capable of promoting or inhibiting the expression of the gene for the protein or a salt of the compound; an antisense polynucleotide comprising a nucleotide sequence complementary or substantially complementary to a nucleotide sequence of a polynucleotide encoding the protein or a partial peptide thereof or comprising a part of the nucleotide sequence; an antibody directed against the protein; and the like. The compound or salt thereof, antisense nucleotide, antibody or the like can be used as a prophylactic/therapeutic agent for a mental disease, a prolactin-related disease or the like.

摘要翻译： 公开了能够促进或抑制具有与SEQ ID NO：1所示相同或基本相同的氨基酸序列的蛋白质或该化合物的盐的活性的化合物; 能够促进或抑制蛋白质或该化合物的盐的基因表达的化合物; 包含与编码所述蛋白质或其部分肽的多核苷酸的核苷酸序列互补或基本互补的核苷酸序列或包含所述核苷酸序列的一部分的反义多核苷酸; 针对蛋白质的抗体; 等等。 化合物或其盐，反义核苷酸，抗体等可以用作精神疾病，催乳素相关疾病等的预防/治疗剂。