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公开(公告)号：EP2851095A4
公开(公告)日：2015-06-17
申请号：EP13791531
申请日：2013-05-13
发明人： KAGEYAMA YUKAKO , FUJINAGA KENTARO , YAMAGUCHI AYUKO , AKIYAMA YUSUKE , OONO AKITOSHI , HONDA SUSUMU , SATAKE MAKOTO , KANEKO HIROAKI , IMAMURA TAKAYUKI , KAWAMURA RYOICHI , HIRASHIMA MASAKI
CPC分类号： A61L26/0066 , A61K38/363 , A61K38/4833 , A61L24/0015 , A61L24/0036 , A61L24/0042 , A61L24/043 , A61L26/0052 , A61L26/0085 , A61L26/009 , A61L2300/25 , A61L2300/252 , A61L2300/418 , A61L2400/04 , C08L89/00
摘要： A formed sheet product of a polymer composition comprising at least one protein selected from the group consisting of fibrinogen and thrombin and at least one polymer selected from the group consisting of an aliphatic polyester and a water-soluble polymer, and a laminated formed sheet product comprising a first polymer composition layer composed of fibrinogen and a water-soluble polymer and a second polymer composition layer composed of thrombin and an aliphatic polyester are provided. These formed products are applied onto a wound site and function as a hemostatic material.
摘要翻译： 包含至少一种选自纤维蛋白原和凝血酶的蛋白质的聚合物组合物和至少一种选自脂族聚酯和水溶性聚合物的聚合物的聚合物组合物的片状产品，以及包含 提供由纤维蛋白原和水溶性聚合物组成的第一聚合物组合物层和由凝血酶和脂族聚酯组成的第二聚合物组合物层。 这些形成的产品被施加到伤口部位并用作止血材料。
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公开(公告)号：EP2851083A4
公开(公告)日：2015-05-06
申请号：EP13790434
申请日：2013-05-13
发明人： KAGEYAMA YUKAKO , FUJINAGA KENTARO , YAMAGUCHI AYUKO , AKIYAMA YUSUKE , KATOU SOUICHIROU , KIMURA YUKIKO , HONDA SUSUMU , SATAKE MAKOTO , KANEKO HIROAKI , ISHIWARI AYUMI , HIRASHIMA MASAKI
CPC分类号： A61K47/38 , A61K9/7007 , A61K38/1709 , A61K38/465 , A61K38/47 , A61K38/4833 , A61L15/225 , A61L17/10 , A61L27/26 , A61L27/505 , A61L28/0026 , A61L29/049 , A61L31/041 , A61L31/143 , C12Y302/01021 , C08L1/00 , C08L89/00
摘要： A protein composition which comprises a mixture of glycine, phenylalanine and histidine and/or a cellulose ether derivative as an additive and has resistance to radiation sterilization.
摘要翻译： 一种蛋白质组合物，其包含甘氨酸，苯丙氨酸和组氨酸和/或纤维素醚衍生物作为添加剂的混合物，并且具有耐辐射灭菌功能。
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公开(公告)号：EP2851085A4
公开(公告)日：2015-04-15
申请号：EP13791568
申请日：2013-05-13
发明人： KAGEYAMA YUKAKO , FUJINAGA KENTARO , YAMAGUCHI AYUKO , HONDA SUSUMU , SATAKE MAKOTO , KANEKO HIROAKI , ISHIWARI AYUMI
CPC分类号： A61K9/70 , A61K9/0024 , A61K38/363 , A61K38/465 , A61K38/47 , A61K38/4833 , A61K47/34 , C12Y301/01003 , C12Y302/01021 , C12Y304/21005
摘要： A sterile composition which comprises a protein and an aliphatic polyester containing the protein and is sterilized with radiation. In this sterile composition, the structure and function (activity) of the protein are retained.
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公开(公告)号：EP2594269A4
公开(公告)日：2013-12-04
申请号：EP11795774
申请日：2011-06-15
申请人： TEIJIN PHARMA LTD
发明人： FUJINAGA KENTARO , MARUO SUSUMU , NAKAMURA HIDEAKI , SUNAGAWA KENJI , MOCHIZUKI TSUTOMU , KAGEYAMA MICHIHARU
IPC分类号： A61K31/426 , A61K9/24 , A61K9/26 , A61K9/28 , A61K47/38
CPC分类号： A61K9/2866 , A61K9/2018 , A61K9/2054 , A61K9/209 , A61K31/426
摘要： Disclosed is a controlled release nucleated tablet which is composed of an inner nucleus and an outer layer that covers the inner nucleus and is capable of maintaining the level of 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5- thiazolecarboxylic acid in the blood to a certain value or higher for a long period of time. The controlled release nucleated tablet is characterized in that the inner nucleus contains 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5- thiazolecarboxylic acid and the outer layer contains 2-(3-cyano- 4-isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylic acid and a gel-forming water-soluble polymer that is in an amount of 16 (w/w)% or more relative to the weight of the outer layer.
摘要翻译： 公开了一种控制释放有核的片剂，其由内核和覆盖内核的外层组成，并且能够维持2-（3-氰基-4-异丁氧基苯基）-4-甲基-5-噻唑甲酸 血液中的酸长时间达到一定值或更高。 控释片核片的特征在于内核含有2-（3-氰基-4-异丁氧基苯基）-4-甲基-5-噻唑甲酸，外层含有2-（3-氰基-4-异丁氧基苯基） - 4-甲基-5-噻唑羧酸和相对于外层重量为16（w / w）％以上的凝胶形成性水溶性聚合物。
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公开(公告)号：EP1179344A4
公开(公告)日：2004-05-06
申请号：EP00900919
申请日：2000-01-25
申请人： TEIJIN LTD
发明人： SAKON KIYOYUKI , IGARASHI YOSHIAKI , NARASAKI MASAHIKO , FUJINAGA KENTARO , YAMAMOTO YOJI , MITSUHASHI HIROAKI , TSURUTA KAZUOKI , TANABE HIROFUMI
IPC分类号： A61K9/22 , A61K9/32 , A61K9/36 , A61K9/58 , A61K9/62 , C07D211/26 , A61K31/445 , A61K31/155 , A61K31/192 , A61K31/216 , A61K47/30 , A61K47/38 , A61P1/00 , A61P43/00 , C07D211/62
CPC分类号： C07D211/26
摘要： Medicinal compositions which contain at least one member selected from among compounds represented by general formula (I), salts of these compounds, solvates of these compounds and solvates of these salts, and can reduce contact of such a compound with components of bile or pancreatic juice.
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