公开(公告)号：EP0836092A2

公开(公告)日：1998-04-15

申请号：EP97307786.0

申请日：1997-10-01

Applicant: TEXAS INSTRUMENTS INC.

Inventor： Melendez, Jose L. ,  Carr, Richard A. ,  Bartholomew, Dwight U.

IPC: G01N21/55

CPC classification number: G01N21/43

Abstract: Disclosed is an integrated miniaturized biochemical sensor (50) which can be used to make critical angle measurements resulting from the differences in refractive index between the sensor's housing (55) and a given sample (40) . In one embodiment, the sensor includes a device platform (111) over which an encapsulating and light transmissive housing (115) is formed to enclose the various sensor components including a light source (105), and a photodetector (107),a signal processing unit (95) and a temperature sensor (95). In another embodiment the housing (115) has a reflective mirrored surface (119) which focuses the light (117) from the light source (105) onto a sensing surface (121) which is in interact with the sample (40) of interest. Light incident from the sensing surface (121) is directed at the photodetector (107,159) which may be an array or single cell. A temperature sensor (95) may also be included and coupled to the platform(111).

Abstract translation: 公开了一种集成的小型化生物传感器（50），其可用于进行由传感器壳体（55）和给定样品（40）之间的折射率差异导致的临界角度测量。 在一个实施例中，传感器包括设备平台（111），其上形成有封装和透光外壳（115），以封闭包括光源（105）和光电检测器（107）的各种传感器部件，信号处理 单元（95）和温度传感器（95）。 在另一个实施例中，外壳（115）具有将来自光源（105）的光（117）聚焦到与感兴趣的样品（40）相互作用的感测表面（121）上的反射镜面（119）。 从感测表面（121）入射的光被引导到可以是阵列或单个单元的光电检测器（107,159）。 还可以包括温度传感器（95）并耦合到平台（111）。

公开(公告)号：EP0834734A3

公开(公告)日：1998-09-16

申请号：EP97307787.8

申请日：1997-10-01

Applicant: TEXAS INSTRUMENTS INC.

Inventor： Melendez, Jose L. ,  Carr, Richard A. ,  Arbuthnot, Diane L.

IPC: G01N21/64

CPC classification number: G01N21/645 ,  G01N21/6428 ,  G01N2201/022

Abstract: An integrated biochemical sensor (200) for detecting the presence of one or more specific samples (240) having a device platform (355) with a light absorbing upper surface and input/output pins (375) is disclosed. An encapsulating housing (357) provides an optical transmissive enclosure which covers the platform (355) and has a layer of fluorescence chemistry on its outer surface (360). The fluorophore is chosen for its molecular properties in the presence of the sample analyte (240), The detector (370), light sources (365, 367, 407, 409) are all coupled to the platform (355) and encapsulated within the housing (357). A filter (375) element is used to block out unwanted light and increase the detector's (370) ability to resolve wanted emission light.

公开(公告)号：EP0834735A2

公开(公告)日：1998-04-08

申请号：EP97307744.9

申请日：1997-10-01

Applicant: TEXAS INSTRUMENTS INC.

Inventor： Carr, Richard A. ,  Melendez, Jose L. ,  Laney, Kirk S.

IPC: G01N21/77

CPC classification number: G01N21/7703 ,  G01N2201/0221 ,  Y10T29/49 ,  Y10T29/49131 ,  Y10T29/49769 ,  Y10T29/53039 ,  Y10T29/53087

Abstract: A miniaturized integrated sensor (50) useful for indicating the presence of a sample analyte is disclosed. The sensor (50) has a platform (52) with an upper surface (53) and a detector (62), light source (60), waveguide (58), and reflective fixtures (60,62) embedded in the platform (52). The light source (60) is preferably a light emitting diode and sits in a cup-shaped dimple (68) that directs light from the light source (60) toward one of the reflective fixtures (64) to uniformly distribute light across the waveguide (58). The waveguide (58) is coupled to an upper surface (53) of the sensor platform (52) and is coated with a thin film of indicator chemistry (70) which interacts with the sample analyte to produce optic signal changes that are measurable by the detector (62). A lead frame (51) in the platform (52) has pins (54, 55, 56) which provide the interface to the outside world. In one embodiment, sensor package (100) has a unique shape that requires a predetermined insertion and removal into an instrument harness or other similar application.

Abstract translation: 公开了一种用于指示样品分析物的存在的小型化集成传感器（50）。 传感器（50）具有平台（52），其具有嵌入平台（52）中的上表面（53）和检测器（62），光源（60），波导（58）和反射夹具（60,62） ）。 光源（60）优选地是发光二极管，并且位于杯形凹坑（68）中，杯形凹坑（68）将来自光源（60）的光引导到反射夹具（64）中的一个以均匀地分布光束穿过波导 58）。 波导（58）耦合到传感器平台（52）的上表面（53），并且涂覆有与样品分析物相互作用的指示剂化学物质（70）的薄膜，以产生光信号变化，其可被 检测器（62）。 平台（52）中的引线架（51）具有向外界提供接口的销（54,55,56）。 在一个实施例中，传感器封装（100）具有独特的形状，其需要预定的插入和移除到仪器线束或其它类似的应用中。

公开(公告)号：EP0834734A2

公开(公告)日：1998-04-08

申请号：EP97307787.8

申请日：1997-10-01

Applicant: TEXAS INSTRUMENTS INC.

Inventor： Melendez, Jose L. ,  Carr, Richard A. ,  Arbuthnot, Diane L.

IPC: G01N21/64

CPC classification number: G01N21/645 ,  G01N21/6428 ,  G01N2201/022

Abstract: An integrated biochemical sensor (200) for detecting the presence of one or more specific samples (240) having a device platform (355) with a light absorbing upper surface and input/output pins (375) is disclosed. An encapsulating housing (357) provides an optical transmissive enclosure which covers the platform (355) and has a layer of fluorescence chemistry on its outer surface (360). The fluorophore is chosen for its molecular properties in the presence of the sample analyte (240), The detector (370), light sources (365, 367, 407, 409) are all coupled to the platform (355) and encapsulated within the housing (357). A filter (375) element is used to block out unwanted light and increase the detector's (370) ability to resolve wanted emission light.

Abstract translation: 公开了一种用于检测具有光吸收上表面和输入/输出销（375）的装置平台（355）的一个或多个特定样品（240）的存在的集成生物化学传感器（200）。 封装壳体（357）提供覆盖平台（355）并且在其外表面（360）上具有一层荧光化学物质的透光外壳。 在样品分析物（240）的存在下，选择荧光团用于其分子性质。检测器（370），光源（365,367,407,409）都耦合到平台（355）并且封装在壳体 （357）。 滤波器（375）元件用于阻止不需要的光，并增加检测器（370）解决所需发射光的能力。

公开(公告)号：EP0834735A3

公开(公告)日：1999-08-11

申请号：EP97307744.9

申请日：1997-10-01

Applicant: TEXAS INSTRUMENTS INC.

Inventor： Carr, Richard A. ,  Melendez, Jose L. ,  Laney, Kirk S.

IPC: G01N21/77

CPC classification number: G01N21/7703 ,  G01N2201/0221 ,  Y10T29/49 ,  Y10T29/49131 ,  Y10T29/49769 ,  Y10T29/53039 ,  Y10T29/53087

Abstract: A miniaturized integrated sensor (50) useful for indicating the presence of a sample analyte is disclosed. The sensor (50) has a platform (52) with an upper surface (53) and a detector (62), light source (60), waveguide (58), and reflective fixtures (60,62) embedded in the platform (52). The light source (60) is preferably a light emitting diode and sits in a cup-shaped dimple (68) that directs light from the light source (60) toward one of the reflective fixtures (64) to uniformly distribute light across the waveguide (58). The waveguide (58) is coupled to an upper surface (53) of the sensor platform (52) and is coated with a thin film of indicator chemistry (70) which interacts with the sample analyte to produce optic signal changes that are measurable by the detector (62). A lead frame (51) in the platform (52) has pins (54, 55, 56) which provide the interface to the outside world. In one embodiment, sensor package (100) has a unique shape that requires a predetermined insertion and removal into an instrument harness or other similar application.

公开(公告)号：EP0846946A3

公开(公告)日：1998-09-16

申请号：EP97308914.7

申请日：1997-11-06

Applicant: TEXAS INSTRUMENTS INC.

Inventor： Bartholomew, Dwight U. ,  Carr, Richard A. ,  Melendez, Jose L.

IPC: G01N21/55

CPC classification number: G01N21/553

Abstract: A sensor control and data analysis system (100) for detecting and analyzing various (bio) chemical properties of a given sample substance (107) using an integrated SPR sensor (50) or other miniaturized sensor configuration. In one embodiment, raw sensor data from the sensing device (105) is transferred to a remote processing system (111), such as a desktop computer, having a display (125), keyboard or other user control and data entry device (123), internal storage area (125), internal microprocessor (117) and a communications means (129). The processing system (111) runs a software application program (115) that receives the raw sample data and perform qualitative and quantitative analysis to render meaningful information about the sample substance. The application program (115) includes a plurality of information screen areas in the form of a graphical user interface (200) having at least an analysis region (206), a plot region (208), a sensor settings region (210) and a sensor status region (214) among others.

公开(公告)号：EP0836092A3

公开(公告)日：1998-09-16

申请号：EP97307786.0

申请日：1997-10-01

Applicant: TEXAS INSTRUMENTS INC.

Inventor： Melendez, Jose L. ,  Carr, Richard A. ,  Bartholomew, Dwight U.

IPC: G01N21/55

CPC classification number: G01N21/43

Abstract: Disclosed is an integrated miniaturized biochemical sensor (50) which can be used to make critical angle measurements resulting from the differences in refractive index between the sensor's housing (55) and a given sample (40) . In one embodiment, the sensor includes a device platform (111) over which an encapsulating and light transmissive housing (115) is formed to enclose the various sensor components including a light source (105), and a photodetector (107),a signal processing unit (95) and a temperature sensor (95). In another embodiment the housing (115) has a reflective mirrored surface (119) which focuses the light (117) from the light source (105) onto a sensing surface (121) which is in interact with the sample (40) of interest. Light incident from the sensing surface (121) is directed at the photodetector (107,159) which may be an array or single cell. A temperature sensor (95) may also be included and coupled to the platform(111).

Abstract translation: 公开了一种集成的小型化生物化学传感器（50），其可用于由传感器壳体（55）和给定样品（40）之间的折射率差异进行临界角度测量。 在一个实施例中，传感器包括设备平台（111），在该设备平台上方形成封装和透光外壳（115）以封闭包括光源（105）和光电检测器（107）的各种传感器组件，信号处理 单元（95）和温度传感器（95）。 在另一个实施例中，外壳（115）具有反射镜面（119），其将来自光源（105）的光（117）聚焦到与感兴趣的样本（40）相互作用的感测表面（121）上。 从感测表面（121）入射的光指向光电探测器（107,159），其可以是阵列或单个单元。 温度传感器（95）也可以被包括并耦合到平台（111）。

公开(公告)号：EP0846946A2

公开(公告)日：1998-06-10

申请号：EP97308914.7

申请日：1997-11-06

Applicant: TEXAS INSTRUMENTS INC.

Inventor： Bartholomew, Dwight U. ,  Carr, Richard A. ,  Melendez, Jose L.

IPC: G01N21/55

CPC classification number: G01N21/553

Abstract: A sensor control and data analysis system (100) for detecting and analyzing various (bio) chemical properties of a given sample substance (107) using an integrated SPR sensor (50) or other miniaturized sensor configuration. In one embodiment, raw sensor data from the sensing device (105) is transferred to a remote processing system (111), such as a desktop computer, having a display (125), keyboard or other user control and data entry device (123), internal storage area (125), internal microprocessor (117) and a communications means (129). The processing system (111) runs a software application program (115) that receives the raw sample data and perform qualitative and quantitative analysis to render meaningful information about the sample substance. The application program (115) includes a plurality of information screen areas in the form of a graphical user interface (200) having at least an analysis region (206), a plot region (208), a sensor settings region (210) and a sensor status region (214) among others.

Abstract translation: 一种传感器控制和数据分析系统（100），用于使用集成的SPR传感器（50）或其它小型化传感器配置来检测和分析给定样品物质（107）的各种（生物）化学性质。 在一个实施例中，来自感测设备（105）的原始传感器数据被传送到具有显示器（125），键盘或其他用户控制和数据输入设备（123）的远程处理系统（111），例如台式计算机， ，内部存储区域（125），内部微处理器（117）和通信装置（129）。 处理系统（111）运行软件应用程序（115），其接收原始采样数据并执行定性和定量分析以呈现关于样本物质的有意义的信息。 应用程序（115）包括具有至少分析区域（206），绘图区域（208），传感器设置区域（210）和图形用户界面（200）的图形用户界面（200）形式的多个信息屏幕区域 传感器状态区域（214）等。