公开(公告)号：EP1882039A2

公开(公告)日：2008-01-30

申请号：EP06770687.9

申请日：2006-05-19

申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

发明人： CHAKRABARTY, Ananda ,  GUPTA, Tapas, Das ,  YAMADA, Tohru ,  CHAUDHARI, Anita ,  FIALHO, Arsenio ,  HONG, Chang, Soo

IPC分类号： C12P21/04

CPC分类号： C07K14/80 ,  A61K38/00 ,  C07K14/195 ,  Y02A50/386 ,  Y02A50/411 ,  Y02A50/466

摘要： The present invention relates to cupredoxin and cytochrome and their use, separately or together, to inhibit the spread of parasitemia in mammalian red blood cells and other tissues infected by the malaria parasite, and in particular the parasitemia of human red blood cells by P. falciparum. The invention provides isolated peptides that are variants, derivatives or structural equivalents of cupredoxins or cytochrome c, and compositions comprising cupredoxins and/or cytochrome c, or variants, derivatives or structural equivalents thereof, that are useful for treating or preventing malaria infection in mammals. Further, the invention provides methods to treat mammalian patients to prevent or inhibit the growth of malarial infection in mammals. The invention also provides methods to prevent the growth of malaria infection in insect vectors.