公开(公告)号：EP1883650A2

公开(公告)日：2008-02-06

申请号：EP06770729.9

申请日：2006-05-19

申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

发明人： CHAKRABARTY, Ananda ,  GUPTA, Tapas Das ,  YAMADA, Tohru ,  CHAUDHARI, Anita ,  FIALHO, Arsenio ,  HONG, Chang Soo

IPC分类号： C07K14/195 ,  C07K14/82

CPC分类号： C07K14/80 ,  A61K38/00 ,  C07K14/195 ,  C07K14/21 ,  C12N9/0006 ,  Y02A50/386 ,  Y02A50/466

摘要： The present invention relates to cupredoxin, specifically Pseudomonas aeruginosa azurin, and/or Pseudomonas aeruginosa cytochrome c551 and their use in inhibiting of viral infection, and in particular infection of mammalian cells by the Human Immunodeficiency Virus (HIV). The invention also relates to variants and derivatives of cupredoxin and cytochrome c that retain the ability to inhibit viral infection, and in particular infection by the Human Immunodeficiency Virus (HIV). The invention also relates to research methods for studying viral and bacterial infection in mammalian cells.

公开(公告)号：EP2117573A2

公开(公告)日：2009-11-18

申请号：EP08727595.4

申请日：2008-01-11

申请人： The Board Of Trustees Of The University Of Illinois

发明人： CHAUDHARI, Anita ,  CHAKRABARTY, Ananda ,  DAS GUPTA, Tapas ,  FIALHO, Arsenio ,  YAMADA, Tohru ,  ZHU, Yonghua

IPC分类号： A61K38/00

CPC分类号： C07K14/21 ,  A61K38/00

摘要： The present invention relates to compositions and methods of use of cupredoxins, and variants, derivatives and structural equivalents of cupredoxins that interfere with the ephrin signaling system in mammalian cells. Specifically, the invention relates to compositions and methods that use cupredoxins, such as azurin, rusticyanin and plastocyanin, and variants, derivatives and structural equivalents thereof, to treat cancer in mammals. The invention specifically includes mutants with altered Eph binding constants and selectivities.

公开(公告)号：EP1888106A2

公开(公告)日：2008-02-20

申请号：EP06813192.9

申请日：2006-05-19

申请人： The Board of Trustees of the University of Illinois - University of Illinois

发明人： CHAKRABARTY, Ananda ,  DAS GUPTA, Tapas ,  YAMADA, Tohru ,  CHAUDHARI, Anita ,  FIALHO, Arsenio ,  ZHU, Yonghua

IPC分类号： A61K39/00 ,  A61K39/02 ,  A61K39/10 ,  A61K39/38 ,  A61K39/095 ,  A61K39/108 ,  A61K49/00 ,  C07K1/00 ,  C07H21/02 ,  C07H21/04

CPC分类号： C07K14/21 ,  A61K38/00 ,  C07K14/195

摘要： The present invention relates to compositions and methods of use of cupredoxins, and variants, derivatives and structural equivalents of cupredoxins that interfere with the ephrin signaling system in mammalian cells. Specifically, the invention relates to compositions and methods that use cupredoxins, such as azurin, rusticyanin and plastocyanin, and variants, derivatives and structural equivalents thereof, to treat cancer in mammals.

公开(公告)号：EP1882039A2

公开(公告)日：2008-01-30

申请号：EP06770687.9

申请日：2006-05-19

申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

发明人： CHAKRABARTY, Ananda ,  GUPTA, Tapas, Das ,  YAMADA, Tohru ,  CHAUDHARI, Anita ,  FIALHO, Arsenio ,  HONG, Chang, Soo

IPC分类号： C12P21/04

CPC分类号： C07K14/80 ,  A61K38/00 ,  C07K14/195 ,  Y02A50/386 ,  Y02A50/411 ,  Y02A50/466

摘要： The present invention relates to cupredoxin and cytochrome and their use, separately or together, to inhibit the spread of parasitemia in mammalian red blood cells and other tissues infected by the malaria parasite, and in particular the parasitemia of human red blood cells by P. falciparum. The invention provides isolated peptides that are variants, derivatives or structural equivalents of cupredoxins or cytochrome c, and compositions comprising cupredoxins and/or cytochrome c, or variants, derivatives or structural equivalents thereof, that are useful for treating or preventing malaria infection in mammals. Further, the invention provides methods to treat mammalian patients to prevent or inhibit the growth of malarial infection in mammals. The invention also provides methods to prevent the growth of malaria infection in insect vectors.