公开(公告)号：EP1904081A2

公开(公告)日：2008-04-02

申请号：EP06787787.8

申请日：2006-07-19

申请人： The Board of Trustees of the University of Illinois - University of Illinois

发明人： MEHTA, Rajeshwari ,  TAYLOR, Brad ,  YAMADA, Tohru ,  BEATTIE, Craig ,  GUPTA, Tapas Das ,  CHAKRABARTY, Ananda

IPC分类号： A61K38/00 ,  A61K39/00 ,  A61K39/02 ,  A61K39/10 ,  A61K39/38 ,  A61K39/095 ,  A61K39/108 ,  A61K49/00 ,  C07K1/00 ,  C07H21/02 ,  C07H21/04

CPC分类号： C07K14/195 ,  A61K38/00 ,  G01N2333/415 ,  G01N2800/32

摘要： The present invention relates to compositions comprising cupredoxins, and their use to inhibit angiogenesis in mammalian cells, tissues, and animals, and particularly the angiogenesis that accompanies tumor development and particularly in humans. Specifically, the present invention relates to compositions comprising the cupredoxin(s), and or peptides that are variants, derivatives or structural equivalents of cupredoxins, which retain the ability to inhibit angiogenesis in mammalian cells, tissues or animals. These compositions may be peptides or pharmaceutical compositions, among others. The compositions of the invention may be used to treat any pathological condition that has as a symptom or cause, inappropriate angiogenesis, and particularly inappropriate angiogenesis related to tumor development.

公开(公告)号：EP1883650A2

公开(公告)日：2008-02-06

申请号：EP06770729.9

申请日：2006-05-19

申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

发明人： CHAKRABARTY, Ananda ,  GUPTA, Tapas Das ,  YAMADA, Tohru ,  CHAUDHARI, Anita ,  FIALHO, Arsenio ,  HONG, Chang Soo

IPC分类号： C07K14/195 ,  C07K14/82

CPC分类号： C07K14/80 ,  A61K38/00 ,  C07K14/195 ,  C07K14/21 ,  C12N9/0006 ,  Y02A50/386 ,  Y02A50/466

摘要： The present invention relates to cupredoxin, specifically Pseudomonas aeruginosa azurin, and/or Pseudomonas aeruginosa cytochrome c551 and their use in inhibiting of viral infection, and in particular infection of mammalian cells by the Human Immunodeficiency Virus (HIV). The invention also relates to variants and derivatives of cupredoxin and cytochrome c that retain the ability to inhibit viral infection, and in particular infection by the Human Immunodeficiency Virus (HIV). The invention also relates to research methods for studying viral and bacterial infection in mammalian cells.