-
1.发明授权Targeted delivery of drugs, therapeutic nucleic acids and functional nucleic acids to mammalian cells via intact killed bacterial cells 有权的使用完整杀死细菌细胞的药物，治疗性核酸，和功能性核酸在哺乳动物细胞中靶向递送
公开(公告)号：EP2712618B1
公开(公告)日：2016-10-19
申请号：EP13191266.9
申请日：2007-06-20
CPC分类号： A61K47/46 , A61K31/337 , A61K31/704 , A61K31/7088 , A61K31/7105 , A61K31/711 , A61K31/713 , A61K47/6849 , A61K47/6901 , A61K48/00 , A61K48/0008 , A61K2039/505 , C07K16/1203 , C07K16/1235 , C07K16/2863 , C07K2317/31 , Y02A50/481
摘要： A composition comprising intact killed bacterial cells that contain a therapeutic nucleic acid, a drug or a functional nucleic acid is useful for targeted delivery to mammalian cells. The targeted delivery optionally employs bispecific ligands, comprising a first arm that carries specificity for a killed bacterial cell surface structure and a second arm that carries specificity for a mammalian cell surface receptor, to target killed bacterial cells to specific mammalian cells and to cause endocytosis of the killed bacterial cells by the mammalian cells. Alternatively, the delivery method exploits the natural ability of phagocytic mammalian cells to engulf killed bacterial cells without the use of bispecific ligands.
-
公开(公告)号：EP2912060A4
公开(公告)日：2016-06-01
申请号：EP13851374
申请日：2013-10-29
发明人： LAI SAMUEL , WANG YING-YING , KANNAN ARTHI , NUNN KENNETTA , SUBRAMANI DURAI BABU , CONE RICHARD
IPC分类号： C07K16/18 , A61K39/00 , A61K39/395 , A61P15/00 , A61P31/00 , A61P37/00 , C07K16/08 , C07K16/12 , C07K16/14
CPC分类号： C07K16/1235 , A61K2039/505 , C07K16/087 , C07K16/18 , C07K2317/41 , C07K2317/71 , C07K2317/72
摘要： The presently-disclosed subject matter relates to antibodies, compositions, and methods for inhibiting and treating pathogen infection and providing contraception. In particular, the presently-disclosed subject matter relates to inhibiting and treating pathogen infection and providing contraception in a subject using compositions and antibodies capable of trapping pathogens or sperm in mucus, thereby inhibiting transport of pathogens or sperm across mucus secretions. The subject matter further relates to methods for monitoring the effectiveness of vaccines by detecting antibodies capable of trapping pathogens in mucus.
-
3.发明公开VERWENDUNG EINES MITTELS AUS ANTIKÖRPERN UND/ODER INSULIN-LIKE GROWTH FACTOR-ANTAGONISTEN 审中-公开使用抗体和/或胰岛素样生长因子拮抗剂的方法
公开(公告)号：EP2694540A2
公开(公告)日：2014-02-12
申请号：EP12710749.8
申请日：2012-03-28
申请人： MAT Malta Advanced Technologies Limited , Freistaat Bayern vertreten durch die Julius-Maximilians-Universität Würzburg
IPC分类号： C07K16/02 , C07K16/12 , A61K39/395 , A61P25/00
CPC分类号： A61K39/40 , A61K2039/507 , C07K16/1203 , C07K16/1232 , C07K16/1235 , C07K16/1275 , C07K16/1282 , C07K16/14 , C07K2317/11 , C07K2317/23
摘要： The invention relates to the use of an agent selected from the group consisting of antibodies, antibody portions, insulin-like growth factor antagonists, toll-like receptor antagonists, and mixtures thereof for the treatment or the prophylaxis of certain diseases.
-
4.发明公开Delivering functional nucleic acids to mammalian cells via bacterially-derived, intact minicells 有权在通过完整的哺乳动物细胞，细菌微细胞衍生的功能性核酸转移
公开(公告)号：EP2386640A2
公开(公告)日：2011-11-16
申请号：EP11171410.1
申请日：2005-08-25
CPC分类号： A61K9/5068 , A61K31/4745 , A61K31/713 , A61K39/39558 , A61K39/40 , A61K47/46 , A61K47/48776 , A61K47/6901 , A61K47/6923 , A61K48/0008 , C07K16/1235 , C07K16/2863 , C07K16/40 , C07K2317/31 , C12N15/111 , C12N15/113 , C12N15/1135 , C12N15/1137 , C12N15/1138 , C12N2310/11 , C12N2310/111 , C12N2310/14 , C12N2310/141 , C12N2310/531 , C12N2320/32 , Y02A50/473
摘要： Intact bacterially derived minicells containing functional nucleic acids or plasmids encoding functional nucleic acids can reduce, in targeted mammalian cells, drug resistance, apoptosis resistance, and neoplasticity, respectively. Methodology that employs minicells to deliver functional nucleic acids, targeting the transcripts of proteins that contribute to drug resistance or apoptosis resistance, inter alia, can be combined with chemotherapy to increase the effectiveness of the chemotherapy.
摘要翻译： 完整细菌来源的微型细胞含有功能性核酸或质粒编码功能性核酸可以分别减少，在靶向哺乳动物细胞，抗药性，细胞凋亡抗性，和致瘤性。 方法也采用微型细胞递送功能性核酸，靶向蛋白的转录并促进药物抗性或凋亡抗性，特别是可与化学疗法相结合，以增加化疗的效果。
-
5.发明公开DELIVERING FUNCTIONAL NUCLEIC ACIDS TO MAMMALIAN CELLS VIA BACTERIALLY DERIVED, INTACT MINICELLS 审中-公开电源功能的核酸哺乳动物OVER源自细菌原状MINI细胞
公开(公告)号：EP1791959A4
公开(公告)日：2009-03-18
申请号：EP05806875
申请日：2005-08-25
IPC分类号： C12N15/63 , A61K48/00 , C12N15/11 , C12N15/113
CPC分类号： A61K9/5068 , A61K31/4745 , A61K31/713 , A61K39/39558 , A61K39/40 , A61K47/46 , A61K47/48776 , A61K47/6901 , A61K47/6923 , A61K48/0008 , C07K16/1235 , C07K16/2863 , C07K16/40 , C07K2317/31 , C12N15/111 , C12N15/113 , C12N15/1135 , C12N15/1137 , C12N15/1138 , C12N2310/11 , C12N2310/111 , C12N2310/14 , C12N2310/141 , C12N2310/531 , C12N2320/32
摘要： Intact bacterially derived minicells containing functional nucleic acids or plasmids encoding functional nucleic acids can reduce, in targeted mammalian cells, drug resistance, apoptosis resistance, and neoplasticity, respectively. Methodology that employs minicells to deliver functional nucleic acids, targeting the transcripts of proteins that contribute to drug resistance or apoptosis resistance, inter alia, can be combined with chemotherapy to increase the effectiveness of the chemotherapy.
-
公开(公告)号：EP1064551A4
公开(公告)日：2005-01-05
申请号：EP99913925
申请日：1999-03-18
申请人： UNIV COLUMBIA
发明人： TRAKHT ILYA
IPC分类号： G01N33/577 , A61K39/395 , A61K39/42 , A61P31/00 , A61P35/00 , A61P37/06 , C07K16/00 , C07K16/12 , C07K16/28 , C07K16/30 , C12N1/15 , C12N1/21 , C12N5/10 , C12N5/16 , C12N5/26 , C12N15/02 , C12P21/08 , G01N33/569 , G01N33/574 , G01N33/68 , G01N33/53
CPC分类号： C07K16/3069 , C07K16/1235 , C07K16/2863 , C07K16/3015 , C07K2317/21 , C12N5/163 , C12N5/166 , C12N2510/02 , C12N2510/04 , G01N33/56983 , G01N33/57484 , G01N33/6893 , Y10S530/808 , Y10S530/809
-
公开(公告)号：EP0663404B1
公开(公告)日：2002-04-10
申请号：EP95100067.8
申请日：1995-01-04
申请人： MERCK PATENT GmbH
发明人： Schubert, Dr. Peter , Neumann, Dr. Siegfried , Burger, Dr. Christa , Linxweiler, Dr. Winfried , Bubert, Dr. Andreas , Goebel, Prof. Dr. Werner , Mollenkopf, Hans-Joachim
IPC分类号： C07K14/255 , C07K16/12 , A61K38/10 , A61K39/112
CPC分类号： C07K14/255 , A61K39/00 , C07K16/1235 , Y02A50/476
-
8.发明授权SEQUENCES NUCLEIQUES ISSUES DU GENOME DE $i(SALMONELLA) TYPHI, ET LEURS UTILISATIONS NOTAMMENT POUR LE DIAGNOSTIC $i(IN VITRO) DE LA PRESENCE DE BACTERIES DU GENRE $i(SALMONELLA) DANS LES PRODUITS ALIMENTAIRES 失效SALMONELLA GENOMENÜKLEINSÄURE，使用，尤其是在体外诊断PRESENCE食物中的沙门氏菌属细菌的作者
公开(公告)号：EP0538353B1
公开(公告)日：1996-06-12
申请号：EP91913033.6
申请日：1991-07-11
IPC分类号： C12N15/31 , C07K14/255 , C12Q1/68 , G01N33/569
CPC分类号： C12Q1/689 , C07K14/255 , C07K16/1235 , Y02A50/59
摘要： Nucleic sequences from the genome of Salmonella Typhi include all or part of the genetic information required for the in vitro infection of cultured HeLa cells by Salmonella bacteria. Polypeptides encoded by these nucleic sequences are also described, as is the use of said polypeptides and nucleic sequences for implementing methods of in vitro Salmonella detection in biological samples which are thought to contain it.
-
公开(公告)号：EP0193576A1
公开(公告)日：1986-09-10
申请号：EP85904473.0
申请日：1985-09-09
CPC分类号： C07K16/1235 , A61K38/00
摘要： Des anticorps monoclonaux pour le genre Salmonella, les anticorps marqués, compositions et kits les contenant, et leur utilisation pour le diagnostic d'antigènes et le traitement.
-
10.发明公开Vaccine and serum for endotoxin associated disease and method of preparing same as well as methods of immunisation and treatment of such disease and to a detoxified endotoxin and bacterial mutant 失效疫苗和血清内毒素相关的疾病和它们的制造和用于免疫和治疗这些疾病的，并且细菌内毒素突变体enttoxifierte方法的方法。
公开(公告)号：EP0158282A2
公开(公告)日：1985-10-16
申请号：EP85104085.7
申请日：1985-04-03
IPC分类号： A61K39/112 , A61K39/40 , A61K39/02
CPC分类号： C12R1/42 , A61K38/00 , A61K39/0275 , A61K39/39 , A61K2039/521 , A61K2039/55572 , A61K2039/55583 , A61K2039/55594 , C07K16/1228 , C07K16/1232 , C07K16/1235 , Y02A50/482
摘要： A combination vaccine, with methods of preparation and treatment, for protection against Gram negative bacterial diseases. The vaccine includes a killed suspension of a bacterial mutant from the taxonomic family Enterobacteriaceae, a B-lymphocyte proliferating immune modulator, and a protein and lipid binding adjuvant. A hyperimmune serum for treating diseased animals is prepared by vaccinating a donor animal with the combination vaccine and then preparing clot serum containing antigen specific antibodies. The mutant is ATCC No. 53000 and is produced by ionizing radiation of Salmonella enteritidis. The immune modulator is a detoxified extract of lipopolysaccharide and is useful with many antigens to enhance primary immune response.
摘要翻译： 的组合疫苗，其中制备和处理的方法，对革兰氏阴性细菌性疾病的保护。 该疫苗包括从分类学肠杆菌科，B-淋巴细胞增殖免疫调节剂的细菌突变体的杀死悬浮液，以及蛋白质和脂质结合佐剂。 对于治疗患病动物甲超免疫血清通过接种的供体动物与所述组合疫苗，然后制备凝块含有血清的抗原特异性抗体制备。 所述突变体是ATCC号 53000，并且由电离肠炎沙门氏菌的辐射产生。 免疫调节剂是脂多糖的解毒提取物和与许多抗原以增强初级免疫应答是有用的。
-
-
-
-
-
-
-
-
-
搜索结果
58 条记录 (耗时 0.022 秒)
