-
公开(公告)号：EP0291605B1
公开(公告)日：1993-03-31
申请号：EP87309644.0
申请日：1987-10-30
IPC分类号： A61K43/00
CPC分类号： A61K51/0489 , A61K2121/00
-
2.发明授权Macrocyclic bifunctional chelants, complexes thereof and their antibody conjugates 失效大环双功能螯合剂，它们的复合物和它们的共轭的抗体。
公开(公告)号：EP0353450B1
公开(公告)日：1995-03-29
申请号：EP89111497.7
申请日：1989-06-23
发明人： Cheng, Roberta C. , Fordyce, William A. , Goeckeler, William F. , Kruper, William F., Jr. , Baughman, Sharon , Garlich, Joseph R. , Kiefer, Garry , McMillan, Kenneth , Simon, Jaime J. , Wilson, David A. , Frank, Richard Keith
IPC分类号： C07D257/02 , A61K31/395 , A61K51/00 , A61K47/00 , A61K49/00
CPC分类号： C07D257/02 , A61K51/0482 , A61K51/1045 , A61K51/109 , A61K2121/00 , A61K2123/00
-
3.发明公开Macrocyclic bifunctional chelants, complexes thereof and their antibody conjugates 失效巨型圆形切割机Chelatbildner，Komplexe davon und ihre konjugiertenAntikörper。
公开(公告)号：EP0353450A1
公开(公告)日：1990-02-07
申请号：EP89111497.7
申请日：1989-06-23
发明人： Cheng, Roberta C. , Fordyce, William A. , Goeckeler, William F. , Kruper, William F., Jr. , Baughman, Sharon , Garlich, Joseph R. , Kiefer, Garry , McMillan, Kenneth , Simon, Jaime J. , Wilson, David A. , Frank, Richard Keith
IPC分类号： C07D257/02 , A61K31/395 , A61K51/00 , A61K47/00 , A61K49/00
CPC分类号： C07D257/02 , A61K51/0482 , A61K51/1045 , A61K51/109 , A61K2121/00 , A61K2123/00
摘要： A group of functionalized polyaminocarboxylate chelants that form complexes with rare earth-type metal ions are disclosed. The complexes can be covalently attached to an antibody or antibody fragment and used for therapeutic and/or diagnostic purposes.
摘要翻译： 公开了与稀土类金属离子形成络合物的一组官能化聚氨基羧酸螯合剂。 复合物可以共价连接到抗体或抗体片段上并用于治疗和/或诊断目的。
-
4.发明授权
公开(公告)号：EP0164843B1
公开(公告)日：1991-06-19
申请号：EP85302634.2
申请日：1985-04-15
发明人： Simon, Jaime , Volkert, Wynn A. , Wilson, David A. , Troutner, David E. , Goeckeler, William F.
IPC分类号： A61K43/00
CPC分类号： A61K51/0478 , A61K51/0489 , A61K2121/00 , C07F9/3817
-
5.发明公开
公开(公告)号：EP0164843A3
公开(公告)日：1987-09-23
申请号：EP85302634
申请日：1985-04-15
发明人： Simon, Jaime , Volkert, Wynn A. , Wilson, David A. , Troutner, David E. , Goeckeler, William F.
IPC分类号： A61K43/00
CPC分类号： A61K51/0478 , A61K51/0489 , A61K2121/00 , C07F9/3817
摘要： Particle-emitting radionuclides, eg. Samarium-153, have been complexed with phosphonic acid derivatives of organic amine or substituted organic amine compounds wherein the nitrogen and phosphorus are interconnected by an alkylene group. These complexes have been found useful in the treatment of calcific tumors in animals.
-
公开(公告)号：EP0291605A3
公开(公告)日：1989-07-26
申请号：EP87309644.0
申请日：1987-10-30
IPC分类号： A61K43/00
CPC分类号： A61K51/0489 , A61K2121/00
摘要： Bone marrow is suppressed by administering at least one bone marrow suppressing radionuclide composition having at least one of Samarium-153, Gadolinium-159, or Holmium-166 and at least one of ethylenediaminetetramethylenephosphonic acid, diethylenetriaminepentamethylenephosphonic acid, hydroxyethylethylenediaminetrimethylenephosphonic acid, nitrilotrimethylenephosphonic acid or tris(2-aminoethyl)aminehexamethylenephosphonic acid, or a physiologically-acceptable salt thereof.
-
公开(公告)号：EP0291605A2
公开(公告)日：1988-11-23
申请号：EP87309644.0
申请日：1987-10-30
IPC分类号： A61K43/00
CPC分类号： A61K51/0489 , A61K2121/00
摘要： Bone marrow is suppressed by administering at least one bone marrow suppressing radionuclide composition having at least one of Samarium-153, Gadolinium-159, or Holmium-166 and at least one of ethylenediaminetetramethylenephosphonic acid, diethylenetriaminepentamethylenephosphonic acid, hydroxyethylethylenediaminetrimethylenephosphonic acid, nitrilotrimethylenephosphonic acid or tris(2-aminoethyl)aminehexamethylenephosphonic acid, or a physiologically-acceptable salt thereof.
摘要翻译： 通过施用至少一种骨髓抑制放射性核素组合物抑制骨髓，所述组合物具有至少一种钐-153，钆-159或钬-166以及至少一种乙二胺四亚甲基膦酸，二亚乙基三胺五亚甲基膦酸，羟乙基乙二胺三亚甲基膦酸，次氮基三亚甲基膦酸或三 2-氨基乙基）胺六亚甲基膦酸或其生理上可接受的盐。
-
8.发明公开Aminocarboxylic acid complexes for the treatment of calcific tumors 失效Aminocarbonsaurekomplexe zur Behandlung von Knochentumoren。
公开(公告)号：EP0176288A1
公开(公告)日：1986-04-02
申请号：EP85306500.1
申请日：1985-09-12
发明人： Simon, Jaime , Wilson, David A. , Volkert, Wynn A. , Troutner, David E. , Goeckeler, William F.
IPC分类号： C07C229/76 , C07C227/00 , C07B59/00 , A61K43/00
CPC分类号： A61K51/0478 , A61K2121/00
摘要： Particle-emitting radionuclides, e.g. Samarium-153, are complexed with aminocarboxylic acid derivatives having at least one of the amine hydrogens replaced by a carboxyalkyl radical to provide complexes having log of stability constant (Log K) from 13 to 20. Physiologically acceptable salts of these complexes are also contemplated. The complexes are useful in the treatment of calcific tumors.
摘要翻译： 颗粒发射放射性核素，例如 钐 - 153与具有至少一个胺氢被羧基烷基取代的氨基羧酸衍生物络合，以提供具有稳定常数（Log K）的对数为13至20的配合物。也考虑了这些络合物的生理学上可接受的盐。 该复合物可用于治疗钙化肿瘤。
-
公开(公告)号：EP0176288B1
公开(公告)日：1990-05-09
申请号：EP85306500.1
申请日：1985-09-12
发明人： Simon, Jaime , Wilson, David A. , Volkert, Wynn A. , Troutner, David E. , Goeckeler, William F.
IPC分类号： C07C229/76 , C07C227/00 , C07B59/00 , A61K43/00
CPC分类号： A61K51/0478 , A61K2121/00
-
10.发明公开Organic amine phosphonic acid complexes for the treatment of calcific tumors 失效有机氨基膦酸酯化合物可以使用Behandlung von Kalktumoren。
公开(公告)号：EP0225409A1
公开(公告)日：1987-06-16
申请号：EP85308772.4
申请日：1985-12-02
发明人： Simon, Jaime , Volkert, Wynn A. , Wilson, David A. , Troutner, David E. , Goeckeler, William F.
CPC分类号： A61K51/0489 , A61K51/0478 , A61K2121/00 , C07F9/3817
摘要： Particle-emitting radionuclides (Y-90 and In-115) have been complexed with phosphonic acid derivatives of organic amine or substituted organic amine compounds wherein the nitrogen and phosphorus are interconnected by an alkylene group. These complexes have been found useful in the treatment of calcific tumors in animals.
摘要翻译： 发射粒子的放射性核素（Y-90和In-115）已经与有机胺或其中氮和磷通过亚烷基相互连接的取代的有机胺化合物的膦酸衍生物络合。 已经发现这些复合物可用于治疗动物中的钙化肿瘤。
-
-
-
-
-
-
-
-
-
搜索结果
11 条记录 (耗时 0.016 秒)
