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1.发明公开SALT AND POLYMORPH OF PYRAZOLOPYRIMIDINONE COMPOUND AND DRUG COMPOSITION, PREPARATION METHOD AND USE THEREOF 有权盐和多晶型吡唑并嘧啶和活性物质，其制造方法相同，它们的用途
公开(公告)号：EP2746284A4
公开(公告)日：2015-01-14
申请号：EP12823704
申请日：2012-08-14
发明人： LI JIANFENG , TIAN GUANGHUI , WANG ZHEN , SUO JIN , JIANG XIANGRUI , LIU ZHENG , YANG XIAOJUN , XIE ZHU , ZHAO XIANGUO , ZHU WEILIANG , JIANG HUALIANG , SHEN JINGSHAN
IPC分类号： C07D487/04 , A61K31/519 , A61P1/00 , A61P9/00 , A61P9/04 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/02 , A61P11/06 , A61P13/00 , A61P13/08 , A61P13/10 , A61P13/12 , A61P15/00 , A61P15/06 , A61P15/10 , A61P25/00 , A61P27/06 , A61P29/00 , A61P37/08
CPC分类号： C07D487/04 , C07B2200/13
摘要： The present invention relates to new salts of pyrazolopyrimidinone represented by formula (I), and pharmaceutically acceptable polymorph, solvate, hydrate, dehydrate, co-crystallization, anhydrous, or amorphous form thereof, the pharmaceutical compositions, and a pharmaceutical unit dosage form containing the same, wherein x represents organic or inorganic acids, preferable maleic acid, succinic acid, methanesulfonic acid, hydrochloric acid, etc. The invention further relates to co-crystals or complexes of compounds of pyrazolopyrimidinone and pharmaceutical compositions containing the same. The present invention also relates to a process for the preparation, use thereof and pharmaceutical preparation containing the salts or crystalline forms.
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2.发明公开N-{1-[3-(2-ETHOXY-5-(4-ETHYLPIPERAZINYL)BENZENESULFONYL)-4,5-DIHYDRO-5-OXO-1,2,4-TRIAZIN-6-YL]ETHYL}BUTYRAMIDE, THE PREPARATION METHOD AND USE THEREOF 有权N- {1- [3-（2-乙氧基-5-（4-乙基哌嗪基）苯磺酰基）-4,5-二氢-5-氧代-1,2,4-三嗪-6-基]乙基}丁酸，METHOD 生产及其用途
公开(公告)号：EP2228370A4
公开(公告)日：2011-06-08
申请号：EP07855873
申请日：2007-12-28
发明人： TIAN GUANGHUI , LIU ZHENG , ZHENG JIN , SHEN JINGSHAN
IPC分类号： C07D487/04 , C07D253/07 , C07D295/26
CPC分类号： C07D295/26 , C07D253/07 , C07D487/04
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公开(公告)号：EP3192792A4
公开(公告)日：2018-05-30
申请号：EP15840920
申请日：2015-09-11
申请人： SUZHOU VIGONVITA LIFE SCIENCES CO LTD , SHANGHAI INST MATERIA MEDICA CAS , TOPHARMAN SHANGHAI CO LTD
发明人： SHEN JINGSHAN , LIU ZHENG , WANG ZHEN , TIAN GUANGHUI , LI JIANFENG , YANG XIAOJUN
IPC分类号： C07D261/20 , A61K31/33 , A61K31/381 , A61K31/415 , A61K31/42 , A61K31/425 , A61P3/04 , A61P25/08 , C07D209/14 , C07D307/77 , C07D333/46
CPC分类号： C07D495/04 , A61K31/33 , A61K31/381 , A61K31/415 , A61K31/42 , A61K31/425 , C07D209/14 , C07D231/56 , C07D261/20 , C07D275/04 , C07D307/77 , C07D333/20 , C07D333/46
摘要： Disclosed are an aminosulfonyl compound represented by general formula I or a tautomer, enantiomer, racemate or pharmaceutically acceptable salt thereof, a preparation method therefor, a pharmaceutical composition and a use thereof. The compound can be used for treating epilepsy, convulsion, obesity and the like.
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4.发明公开PHENYL PYRIMIDONE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, PREPARATION METHODS AND USES THEREOF 有权PHENYLPYRIMIDONVERBINDUNGEN，药物组合物，方法和应用
公开(公告)号：EP2383262A4
公开(公告)日：2012-10-31
申请号：EP09831388
申请日：2009-12-10
发明人： LIU ZHENG , LI JIANFENG , YANG XIAOJUN , WANG ZHEN , ZHANG JINFENG , ZHU YI , TIAN GUANGHUI , JIN QING , SHEN JINGKANG , ZHU WEILIANG , JIANG HUALIANG , SHEN JINGSHAN
IPC分类号： C07D239/36 , A61K31/505 , A61P15/10
CPC分类号： A61K31/505 , C07D239/36 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12 , C07H15/26
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5.发明公开METHODS FOR PREPARING BREXPIPRAZOLE, KEY INTERMEDIATES THEREOF AND SALTS THEREOF 审中-公开用于生产BREXPIPRAZOL，KEY其中间体及其盐
公开(公告)号：EP3059237A4
公开(公告)日：2016-08-24
申请号：EP14854084
申请日：2014-10-20
申请人： SUZHOU VIGONVITA LIFE SCIENCES CO LTD , TOPHARMAN SHANGHAI CO LTD , SHANGHAI INST MATERIA MEDICA
发明人： LIU ZHENG , WU CHUNHUI , LIU YONGJIAN , ZHANG RONGXIA , HE YANG , TIAN GUANGHUI , SHEN JINGSHAN
IPC分类号： C07D409/12 , C07D333/70
CPC分类号： C07D409/12 , C07D333/54 , C07D333/70
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6.发明公开SUBSTITUTED N-PENTANAMIDE COMPOUNDS, PREPARATION METHODS AND USES THEREOF 审中-公开SUBSTITUIERTE N-PENTANAMID-VERBINDUNGEN，HERSTELLUNGSVERFAHRENDAFÜRUND VERWENDUNGEN DAVON
公开(公告)号：EP2671878A4
公开(公告)日：2014-07-23
申请号：EP12742093
申请日：2012-01-31
发明人： ZHANG QIANG , ZHANG RONGXIA , TIAN GUANGHUI , LI JIANFENG , ZHU FUQIANG , JIANG XIANGRUI , SHEN JINGSHAN
IPC分类号： C07D263/26 , C07C17/16 , C07C22/04 , C07C29/159 , C07C33/20 , C07C51/06 , C07C57/30 , C07C209/08 , C07C209/50 , C07C209/62 , C07C231/02 , C07C231/08 , C07C231/12 , C07C303/28 , C07C309/66 , C07D263/62
CPC分类号： C07C235/34 , C07C17/16 , C07C41/26 , C07C43/225 , C07C43/23 , C07C59/64 , C07C59/68 , C07C213/02 , C07C215/54 , C07C217/62 , C07C309/66 , C07C309/73 , C07C309/75 , C07D263/26 , C07D263/52 , Y02P20/582 , C07C22/04
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公开(公告)号：EP1961753A4
公开(公告)日：2009-11-25
申请号：EP06817839
申请日：2006-11-16
发明人： TIAN GUANGHUI , LAI SHUNAN , WANG ZHEN , ZHU YI , CHEN XINJIAN , JI YURONG , ZHANG JINFENG , JIN WEIXI , LV HEPING , LIU JINPING , WANG WEI , JI RUYUN , SHEN JINGSHAN
IPC分类号： C07D487/04 , A61K31/519 , A61P15/10
CPC分类号： C07D487/04
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