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公开(公告)号：EP3192792A4
公开(公告)日：2018-05-30
申请号：EP15840920
申请日：2015-09-11
申请人： SUZHOU VIGONVITA LIFE SCIENCES CO LTD , SHANGHAI INST MATERIA MEDICA CAS , TOPHARMAN SHANGHAI CO LTD
发明人： SHEN JINGSHAN , LIU ZHENG , WANG ZHEN , TIAN GUANGHUI , LI JIANFENG , YANG XIAOJUN
IPC分类号： C07D261/20 , A61K31/33 , A61K31/381 , A61K31/415 , A61K31/42 , A61K31/425 , A61P3/04 , A61P25/08 , C07D209/14 , C07D307/77 , C07D333/46
CPC分类号： C07D495/04 , A61K31/33 , A61K31/381 , A61K31/415 , A61K31/42 , A61K31/425 , C07D209/14 , C07D231/56 , C07D261/20 , C07D275/04 , C07D307/77 , C07D333/20 , C07D333/46
摘要： Disclosed are an aminosulfonyl compound represented by general formula I or a tautomer, enantiomer, racemate or pharmaceutically acceptable salt thereof, a preparation method therefor, a pharmaceutical composition and a use thereof. The compound can be used for treating epilepsy, convulsion, obesity and the like.
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2.发明公开HETEROCYCLIC COMPOUNDS, AND PREPARATION METHOD AND USE THEREOF 审中-公开混合动力学VERBINDUNGEN UND HERSTELLUNGSVERFAHREN UND VERWENDUNG DAVON
公开(公告)号：EP3115361A4
公开(公告)日：2017-04-26
申请号：EP15757771
申请日：2015-03-09
申请人： SHANGHAI INST MATERIA MEDICA CAS , SUZHOU VIGONVITA LIFE SCIENCES CO LTD , TOPHARMAN SHANDONG CO LTD
发明人： JIANG HUALIANG , WANG ZHEN , LI JIANFENG , ZHANG RONGXIA , HE YANG , LIU YONGJIAN , BI MINGHAO , LIU ZHENG , TIAN GUANGHUI , CHEN WEIMING , YANG FEIPU , WU CHUNHUI , WANG YU , JIANG XIANGRUI , YIN JINGJING , WANG GUAN , SHEN JINGSHAN
IPC分类号： C07D409/12 , A61K31/4709 , A61K31/496 , A61K31/517 , A61K31/519 , A61K31/538 , A61K31/5415 , A61K31/55 , A61P25/00 , A61P25/18 , A61P25/22 , A61P25/24 , C07D409/14 , C07D413/12 , C07D417/12 , C07D471/04 , C07D495/04 , C07D519/00
CPC分类号： C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D471/04 , C07D495/04 , C07D519/00
摘要： Provided are heterocyclic compounds represented by formula (I), stereoisomers or pharmaceutically acceptable salts of said compounds, a pharmaceutical composition of said compounds, and an application of said compounds in the preparation of a drug for the prevention and/or treatment of a central nervous system disease.
摘要翻译： 提供由式（I）表示的杂环化合物，所述化合物的立体异构体或药学上可接受的盐，所述化合物的药物组合物，以及所述化合物在制备用于预防和/或治疗中枢神经系统 系统疾病。
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3.发明公开METHODS FOR PREPARING BREXPIPRAZOLE, KEY INTERMEDIATES THEREOF AND SALTS THEREOF 审中-公开用于生产BREXPIPRAZOL，KEY其中间体及其盐
公开(公告)号：EP3059237A4
公开(公告)日：2016-08-24
申请号：EP14854084
申请日：2014-10-20
申请人： SUZHOU VIGONVITA LIFE SCIENCES CO LTD , TOPHARMAN SHANGHAI CO LTD , SHANGHAI INST MATERIA MEDICA
发明人： LIU ZHENG , WU CHUNHUI , LIU YONGJIAN , ZHANG RONGXIA , HE YANG , TIAN GUANGHUI , SHEN JINGSHAN
IPC分类号： C07D409/12 , C07D333/70
CPC分类号： C07D409/12 , C07D333/54 , C07D333/70
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4.发明公开SALT AND POLYMORPH OF PYRAZOLOPYRIMIDINONE COMPOUND AND DRUG COMPOSITION, PREPARATION METHOD AND USE THEREOF 有权盐和多晶型吡唑并嘧啶和活性物质，其制造方法相同，它们的用途
公开(公告)号：EP2746284A4
公开(公告)日：2015-01-14
申请号：EP12823704
申请日：2012-08-14
发明人： LI JIANFENG , TIAN GUANGHUI , WANG ZHEN , SUO JIN , JIANG XIANGRUI , LIU ZHENG , YANG XIAOJUN , XIE ZHU , ZHAO XIANGUO , ZHU WEILIANG , JIANG HUALIANG , SHEN JINGSHAN
IPC分类号： C07D487/04 , A61K31/519 , A61P1/00 , A61P9/00 , A61P9/04 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/02 , A61P11/06 , A61P13/00 , A61P13/08 , A61P13/10 , A61P13/12 , A61P15/00 , A61P15/06 , A61P15/10 , A61P25/00 , A61P27/06 , A61P29/00 , A61P37/08
CPC分类号： C07D487/04 , C07B2200/13
摘要： The present invention relates to new salts of pyrazolopyrimidinone represented by formula (I), and pharmaceutically acceptable polymorph, solvate, hydrate, dehydrate, co-crystallization, anhydrous, or amorphous form thereof, the pharmaceutical compositions, and a pharmaceutical unit dosage form containing the same, wherein x represents organic or inorganic acids, preferable maleic acid, succinic acid, methanesulfonic acid, hydrochloric acid, etc. The invention further relates to co-crystals or complexes of compounds of pyrazolopyrimidinone and pharmaceutical compositions containing the same. The present invention also relates to a process for the preparation, use thereof and pharmaceutical preparation containing the salts or crystalline forms.
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5.发明公开PHENYL PYRIMIDONE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, PREPARATION METHODS AND USES THEREOF 有权PHENYLPYRIMIDONVERBINDUNGEN，药物组合物，方法和应用
公开(公告)号：EP2383262A4
公开(公告)日：2012-10-31
申请号：EP09831388
申请日：2009-12-10
发明人： LIU ZHENG , LI JIANFENG , YANG XIAOJUN , WANG ZHEN , ZHANG JINFENG , ZHU YI , TIAN GUANGHUI , JIN QING , SHEN JINGKANG , ZHU WEILIANG , JIANG HUALIANG , SHEN JINGSHAN
IPC分类号： C07D239/36 , A61K31/505 , A61P15/10
CPC分类号： A61K31/505 , C07D239/36 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12 , C07H15/26
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6.发明公开N-{1-[3-(2-ETHOXY-5-(4-ETHYLPIPERAZINYL)BENZENESULFONYL)-4,5-DIHYDRO-5-OXO-1,2,4-TRIAZIN-6-YL]ETHYL}BUTYRAMIDE, THE PREPARATION METHOD AND USE THEREOF 有权N- {1- [3-（2-乙氧基-5-（4-乙基哌嗪基）苯磺酰基）-4,5-二氢-5-氧代-1,2,4-三嗪-6-基]乙基}丁酸，METHOD 生产及其用途
公开(公告)号：EP2228370A4
公开(公告)日：2011-06-08
申请号：EP07855873
申请日：2007-12-28
发明人： TIAN GUANGHUI , LIU ZHENG , ZHENG JIN , SHEN JINGSHAN
IPC分类号： C07D487/04 , C07D253/07 , C07D295/26
CPC分类号： C07D295/26 , C07D253/07 , C07D487/04
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7.发明公开
公开(公告)号：EP1904493A4
公开(公告)日：2009-08-12
申请号：EP06753117
申请日：2006-07-07
发明人： LI JIANFENG , LIU AIXIANG , CHEN XINJIAN , JIN GUOZHANG , YAN TIEMA , ZHANG RONGXIA , ZHU YI , PAN YANJUN , SHEN JINGSHAN , SHEN JINGKANG
IPC分类号： C07D455/03 , A61K31/4375 , A61P25/00 , A61P25/06 , A61P25/16 , A61P25/18
CPC分类号： C07D455/03
摘要： The present invention relates to tetraliydroprotoberberines of the formula (I) and the physiologically acceptable salts thereof. The invention also relates to the use of the compounds of the formula (I) or pharmaceutically acceptable salts thereof for preparing a pharmaceutical composition for the treatment of a medical disorder susceptible to treatment with dopamine receptor ligand, such as schizophrenia.
摘要翻译： 本发明涉及式（I）的四氢噻喃小檗碱及其生理上可接受的盐。 本发明还涉及式（I）化合物或其药学上可接受的盐在制备用于治疗易受多巴胺受体配体如精神分裂症治疗的医学病症的药物组合物中的用途。
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8.发明公开SUBSTITUTED N-PENTANAMIDE COMPOUNDS, PREPARATION METHODS AND USES THEREOF 审中-公开SUBSTITUIERTE N-PENTANAMID-VERBINDUNGEN，HERSTELLUNGSVERFAHRENDAFÜRUND VERWENDUNGEN DAVON
公开(公告)号：EP2671878A4
公开(公告)日：2014-07-23
申请号：EP12742093
申请日：2012-01-31
发明人： ZHANG QIANG , ZHANG RONGXIA , TIAN GUANGHUI , LI JIANFENG , ZHU FUQIANG , JIANG XIANGRUI , SHEN JINGSHAN
IPC分类号： C07D263/26 , C07C17/16 , C07C22/04 , C07C29/159 , C07C33/20 , C07C51/06 , C07C57/30 , C07C209/08 , C07C209/50 , C07C209/62 , C07C231/02 , C07C231/08 , C07C231/12 , C07C303/28 , C07C309/66 , C07D263/62
CPC分类号： C07C235/34 , C07C17/16 , C07C41/26 , C07C43/225 , C07C43/23 , C07C59/64 , C07C59/68 , C07C213/02 , C07C215/54 , C07C217/62 , C07C309/66 , C07C309/73 , C07C309/75 , C07D263/26 , C07D263/52 , Y02P20/582 , C07C22/04
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9.发明公开PREPARATION METHODS OF 4-ACETYL-2,3,4,5-TETRAHYDRO- BENZO[1,4]DIAZEPINE AND THEIR INTERMEDIATES 有权用于生产4-乙酰基-2,3,4,5-四氢 - 苯并[1,4]及其中间体
公开(公告)号：EP2163538A4
公开(公告)日：2010-11-24
申请号：EP08748526
申请日：2008-05-22
发明人： ZHU FUQIANG , LI HAIHONG , WANG WENZHONG , ZHANG HUI , SHEN JINGSHAN
IPC分类号： C07C205/06 , C07D243/14
CPC分类号： C07C211/29 , C07C209/52 , C07C233/13 , C07C251/24 , C07D243/14
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公开(公告)号：EP1961753A4
公开(公告)日：2009-11-25
申请号：EP06817839
申请日：2006-11-16
发明人： TIAN GUANGHUI , LAI SHUNAN , WANG ZHEN , ZHU YI , CHEN XINJIAN , JI YURONG , ZHANG JINFENG , JIN WEIXI , LV HEPING , LIU JINPING , WANG WEI , JI RUYUN , SHEN JINGSHAN
IPC分类号： C07D487/04 , A61K31/519 , A61P15/10
CPC分类号： C07D487/04
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