公开(公告)号：EP1342723A4

公开(公告)日：2005-02-09

申请号：EP01997196

申请日：2001-11-22

Applicant: TORAY INDUSTRIES

Inventor： SAKAMI SATOSHI ,  KAWAI KOJI ,  MAEDA MASAYUKI ,  AOKI TAKUMI ,  UENO SHINYA

IPC: A61K31/485 ,  A61P11/14 ,  A61P25/04 ,  A61P25/28 ,  A61P37/06 ,  A61P43/00 ,  C07D491/22

CPC classification number: C07D491/22 ,  A61K31/485

Abstract: Indole derivatives represented by the general formula (I) or pharmacologically acceptable salts thereof, and pharmaceutical compositions (particularly d opioid receptor agonist) containing the same: (I) wherein R1 is hydrogen, C¿1-5? alkyl, or the like; R?2¿ is hydrogen, hydroxyl, or the like; R3 is hydrogen, hydroxyl, or the like; -Z- is a bridge having 2 to 5 carbon atoms; m is an integer of 0 to 3; n is an integer of 0 to 10; R?4 and R5¿ are each fluoro, hydroxyl, or the like; R9 is hydrogen, C¿1-5? alkyl, or the like; and R?10 and R11¿ may be united to form O- or the like.

公开(公告)号：EP0805157A4

公开(公告)日：1999-01-07

申请号：EP96932007

申请日：1996-09-26

Applicant: TORAY INDUSTRIES

Inventor： NAGASE HIROSHI ,  KAWAI KOJI ,  ENDO TAKASHI ,  UENO SHINYA ,  MAEDA MASAYUKI ,  SAKAMI SATOSHI

IPC: C07D491/22 ,  A61K31/475

CPC classification number: C07D491/22

Abstract: Indole derivatives typified by the compound 1 or pharmacologically acceptable acid-addition salts thereof. When pharmacologically evaluated, the compound show potent antitussive and analgesic effects and thus are usable in the field of medicines as useful antitussives and analgesics.

Abstract translation: 本发明涉及由以下化合物1表示的吲哚衍生物及其药理学上可接受的酸加成盐。 发现本发明化合物作为药理学评价的结果表现出强烈的镇咳和镇痛作用，并且可用于制药领域作为有效的镇咳药和镇痛药。

公开(公告)号：EP1977997A4

公开(公告)日：2013-06-05

申请号：EP06834408

申请日：2006-12-11

Applicant: TORAY INDUSTRIES

Inventor： SATO KENICHI ,  FUJITA KEISUKE ,  MAEDA MASAYUKI ,  YOSHIKAWA MASAHITO ,  HIGUCHI KAZUYOSHI

IPC: C01B31/02 ,  B01J21/10 ,  B01J23/745 ,  B01J35/10 ,  B82Y30/00 ,  B82Y40/00

CPC classification number: B82Y40/00 ,  B01J21/10 ,  B01J23/745 ,  B01J35/1061 ,  B82Y30/00 ,  C01B32/162 ,  Y10S977/842