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公开(公告)号：EP1124977A1
公开(公告)日：2001-08-22
申请号：EP00958742.9
申请日：2000-08-25
发明人： VAN RAAIJ, Mark, Johan , CUSACK, Stephen , LEGRAND, Valérie , LEISSNER, Philippe , MEHTALI, Majid
IPC分类号： C12N15/861 , C12N5/10 , C12N15/34 , C07K14/075 , A61K48/00
CPC分类号： C07K14/005 , C12N15/86 , C12N2710/10322 , C12N2710/10343 , C12N2710/10345 , C12N2810/10 , C12N2810/40 , C12N2810/851 , C12N2810/854 , C12N2810/859
摘要： The invention concerns a modified adenoviral fibre comprising at least one mutation at the level of one or several residues included in the region of said fibre extending from layer A to layer B and including the loop AB.
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公开(公告)号：EP1242449A1
公开(公告)日：2002-09-25
申请号：EP00985308.6
申请日：2000-11-23
申请人： TRANSGENE S.A.
IPC分类号： C07K14/075 , C12N15/861
CPC分类号： C12N7/00 , A61K48/00 , C07K14/005 , C12N15/86 , C12N2710/10322 , C12N2710/10343 , C12N2710/10345 , C12N2710/10352 , C12N2810/40 , C12N2810/6018 , C12N2810/851 , C12N2810/854 , C12N2810/859
摘要： The invention concerns an adenovirus fibre modified by mutation of one or several residues of the region included between residues 491 and 505 of SEQ ID NO: 1, the viral particles or pseudo-particles comprising such a fibre and their uses.
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公开(公告)号：EP0991763A1
公开(公告)日：2000-04-12
申请号：EP98917294.5
申请日：1998-04-02
CPC分类号： C12N7/00 , A61K38/00 , C07K14/005 , C07K2319/00 , C12N15/86 , C12N2710/10322 , C12N2710/10343 , C12N2710/10345 , C12N2810/851 , C12N2830/00 , C12N2830/42 , C12N2830/60
摘要： The invention relates to an adenovirus fiber modified by the mutation of one or more residues. The residues are directed towards the natural cell receptor in the three-dimensional structure of said adenovirus. The invention further relates to a DNA fragment, and expression vector, and a cell line expressing said fiber, and also concerns an adenovirus, the process for producing this type of adenovirus, and a infectable host cell, as well as their therapeutic application and a corresponding pharmaceutical composition.
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公开(公告)号：EP0991763B1
公开(公告)日：2005-09-28
申请号：EP98917294.5
申请日：1998-04-02
CPC分类号： C12N7/00 , A61K38/00 , C07K14/005 , C07K2319/00 , C12N15/86 , C12N2710/10322 , C12N2710/10343 , C12N2710/10345 , C12N2810/851 , C12N2830/00 , C12N2830/42 , C12N2830/60
摘要： The invention relates to an adenovirus fiber modified by the mutation of one or more residues. The residues are directed towards the natural cell receptor in the three-dimensional structure of said adenovirus. The invention further relates to a DNA fragment, and expression vector, and a cell line expressing said fiber, and also concerns an adenovirus, the process for producing this type of adenovirus, and a infectable host cell, as well as their therapeutic application and a corresponding pharmaceutical composition.
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公开(公告)号：EP1523563A2
公开(公告)日：2005-04-20
申请号：EP03764075.2
申请日：2003-07-10
申请人： TRANSGENE S.A.
IPC分类号： C12N15/86 , C07K14/075 , C12N7/04 , A61K48/00
CPC分类号： C12N15/86 , A61K38/00 , A61K48/00 , C07K14/005 , C12N7/00 , C12N2710/10322 , C12N2710/10343 , C12N2710/10345 , C12N2710/10362 , C12N2810/40
摘要： The present invention concerns a modified adenoviral fiber containing at least one mutation affecting one or more amino acid residue(s) of said adenoviral fiber interacting with at least one glycosaminoglycan and/or sialic acid-containing cellular receptor, as well as a trimer of such a modified adenoviral fiber. The present invention also relates to a DNA fragment, an expression vector encoding said modified adenoviral fiber. The present invention also concerns an adenoviral particle lacking a wild-type fiber and comprising the trimer of modified adenoviral fibers as well as a process for producing such an adenoviral particle. Theto present invention also provides a composition comprising such an adenoviral particle and the therapeutic use thereof.
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