-
公开(公告)号：EP0991763B1
公开(公告)日：2005-09-28
申请号：EP98917294.5
申请日：1998-04-02
CPC分类号： C12N7/00 , A61K38/00 , C07K14/005 , C07K2319/00 , C12N15/86 , C12N2710/10322 , C12N2710/10343 , C12N2710/10345 , C12N2810/851 , C12N2830/00 , C12N2830/42 , C12N2830/60
摘要： The invention relates to an adenovirus fiber modified by the mutation of one or more residues. The residues are directed towards the natural cell receptor in the three-dimensional structure of said adenovirus. The invention further relates to a DNA fragment, and expression vector, and a cell line expressing said fiber, and also concerns an adenovirus, the process for producing this type of adenovirus, and a infectable host cell, as well as their therapeutic application and a corresponding pharmaceutical composition.
-
2.发明授权
公开(公告)号：EP1015618B1
公开(公告)日：2003-07-02
申请号：EP98920613.1
申请日：1998-04-10
发明人： BOUVIER, Michel , LOISEL, Thomas , MARULLO, Stefano , BOULANGER, Pierre , STROSBERG, Arthur, Donny
CPC分类号： C12N15/86 , C07K14/723 , C12N2710/14143
摘要： The invention concerns the production of membrane receptors in an insect baculovirus/cell system; said receptors are obtained from extracellular baculoviruses produced by the infected cells.
-
3.发明公开
公开(公告)号：EP0900280A2
公开(公告)日：1999-03-10
申请号：EP98905474.0
申请日：1998-01-30
CPC分类号： C12N15/86 , A61K38/00 , A61K48/00 , C07K14/70539 , C07K14/78 , C07K2319/00 , C12N2710/10343 , C12N2710/10345 , C12N2810/40 , C12N2810/80 , C12N2810/859 , C12N2830/00 , C12N2830/60
摘要： The invention concerns the use of a polypeptide comprising at least 6 continuous amino acids of the sequence as shown in the sequence identifiers 1 to 5 as cell receptor and/or co-receptor of adenoviruses. It also concerns the use of a cell capable of expressing such a polypeptide and that of a ligand capable of influencing the binding of an adenovirus to a host cell and/or its insertion in said cell. Finally, the invention further concerns a method for selecting or identifying a cell receptor of a virus or part of a viral protein determining the binding of the virus to its cell receptor and the use of a bi-functional ligand for targeting an adenovirus towards a host cell bearing on its surface a surface protein other than the natural cell receptor of said adenovirus.
-
4.发明公开COMPOSE ADJUVANT DE L'IMMUNITE COMPORTANT UNE SEQUENCE ADENOVIRALE EF 审中-公开新的免疫BOOSTER CONNECTION这个全面组合物及其使用方法BOOSTER连接的
公开(公告)号：EP1644489A2
公开(公告)日：2006-04-12
申请号：EP04767869.3
申请日：2004-07-02
申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
发明人： BRIAND, Jean-Paul , BOULANGER, Pierre , BOULANGER, Saw See , FRENKEL, Valérie , GUILLET, Jean-Gérard , BLONDEL, Armelle , LENGAGNE, Renée
IPC分类号： C12N5/06
CPC分类号： C07K14/005 , A61K39/39 , A61K2039/55516 , C12N5/0639 , C12N2501/998 , C12N2710/10322
摘要： The invention relates to a peptide immune booster, comprising: a polypeptide (i) with an amino acid sequence having a length of 30 amino acids contained in the head domain of the fibre protein of the capsid of an adenovirus, said amino acid sequence comprising the sequence of amino acids forming a double ß sheet called EF, contained in said head domain, or a peptide analogue (ii) of said polypeptide (i), the amino acid sequence of which has, by comparison with the sequence of polypeptide (i), at least one substitution or at least one deletion of an amino acid, said analogue peptide conserving the double ß sheet called EF .
-
公开(公告)号：EP0991763A1
公开(公告)日：2000-04-12
申请号：EP98917294.5
申请日：1998-04-02
CPC分类号： C12N7/00 , A61K38/00 , C07K14/005 , C07K2319/00 , C12N15/86 , C12N2710/10322 , C12N2710/10343 , C12N2710/10345 , C12N2810/851 , C12N2830/00 , C12N2830/42 , C12N2830/60
摘要： The invention relates to an adenovirus fiber modified by the mutation of one or more residues. The residues are directed towards the natural cell receptor in the three-dimensional structure of said adenovirus. The invention further relates to a DNA fragment, and expression vector, and a cell line expressing said fiber, and also concerns an adenovirus, the process for producing this type of adenovirus, and a infectable host cell, as well as their therapeutic application and a corresponding pharmaceutical composition.
-
-
-
-
搜索结果
5 条记录 (耗时 0.017 秒)
