公开(公告)号：EP1112742A1

公开(公告)日：2001-07-04

申请号：EP99937010.9

申请日：1999-08-10

申请人： Takara Shuzo Co, Ltd.

发明人： KOBAYASHI, Eiji ,  OHNOGI, Hiromu, A-406, Takarashuzoshataku ,  SAGAWA, Hiroaki, 503, Hamoparesu-Kusatsu ,  TOMINAGA, Takanari ,  NISHIYAMA, Eiji ,  KOYAMA, Nobuto ,  IKAI, Katsushige ,  KATO, Ikunoshin

IPC分类号： A61K31/215 ,  A61K31/22

CPC分类号： A61K31/215 ,  A61K31/22 ,  C07C69/013 ,  C07C2601/10 ,  Y02A50/411

摘要： Remedies or preventives for diseases with a need for immunoregulation, diseases with a need for inhibition of inflammation, diseases with a need for regulation of tumor necrosis factor production, diseases with a need for regulation of fungal growth, diseases with a need for regulation of cell adhesion or disease with a deed for induction of heat-shock protein, which contain as the active ingredient at least one compound selected from among cyclopentenone derivatives represented by general formula [I], optically active isomers and salts thereof, wherein R 1 and R 2 are the same or different and each represents hydrogen, an aliphatic group, an aromatic group or an aromatic aliphatic group.

摘要翻译： 需要免疫调节的疾病的治疗或预防措施，需要抑制炎症的疾病，需要调节肿瘤坏死因子产生的疾病，需要调节真菌生长的疾病，需要的疾病 含有诱导热休克蛋白的细胞的细胞粘附或疾病的调节，其含有作为活性成分的至少一种选自通式Ⅳ所示的环戊烯酮衍生物的化合物，其旋光异构体及其盐，其中R 1和R 2为 相同或不同，各自表示氢，脂族基，芳基或芳族脂族基。

公开(公告)号：EP1176153A1

公开(公告)日：2002-01-30

申请号：EP00904062.7

申请日：2000-02-21

申请人： Takara Shuzo Co, Ltd.

发明人： SAKAI, Takeshi, 203, Raionzumanshon-Shinakawamachi ,  KIMURA, Hitomi ,  KOJIMA, Kaoru ,  KATAYAMA, Kaoru, Central Research Laboratories ,  SHIMANAKA, Kazuo ,  IKAI, Katsushige ,  KATO, Ikunoshin

IPC分类号： C08B37/00 ,  C12N9/38

CPC分类号： C08B37/006 ,  C12N9/2402 ,  C12P19/04

摘要： Sulfated fucogalactan or its salt useful as a reagent for sugar chain engineering or an HGF-production inducer; a degraded product or its salt obtained by treating the sulfated fucogalactan with a sulfated fucogalactan digesting enzyme; the sulfated fucogalactan digesting enzyme useful in sugar chain engineering; a process for producing the degraded product by treating sulfated fucogalactan or its salt with the above enzyme; and a process for producing the sulfated fucogalactan digesting enzyme.

摘要翻译： 用作糖链工程试剂或HGF-产生诱导剂的硫酸盐岩藻糖或其盐; 通过用硫酸化的岩藻糖半乳糖苷消化酶处理硫酸盐岩藻糖半乳聚糖获得的降解产物或其盐; 用于糖链工程的硫酸化的岩藻糖消化酶; 通过用上述酶处理硫酸化岩藻聚糖或其盐来制备降解产物的方法; 以及生产硫酸化岩藻聚糖消化酶的方法。

公开(公告)号：EP1086952A1

公开(公告)日：2001-03-28

申请号：EP99923961.9

申请日：1999-06-08

申请人： Takara Shuzo Co, Ltd.

发明人： ENOKI, Tatsuji ,  TOMONO, Jun ,  KOYAMA, Nobuto ,  IKAI, Katsushige ,  SAGAWA, Hiroaki ,  KATO, Ikunoshin

IPC分类号： C07D493/08 ,  C07D309/32 ,  A61K31/35 ,  A61K7/00 ,  A23L1/30 ,  A23L2/00

CPC分类号： A61K31/7004 ,  A23L3/3535 ,  A23L3/3562 ,  A23L33/10 ,  A23V2002/00 ,  A61K31/35 ,  A61K31/351 ,  A61K31/357 ,  A23V2250/60 ,  A23V2250/608 ,  A23V2250/5024 ,  A23V2250/5036

摘要： Therapeutic or preventive agents for diseases requiring apoptosis induction, cancerous diseases, diseases requiring the inhibition of active oxygen production, those requiring the inhibition of nitrogen monoxide production, those requiring the inhibition of prostaglandin synthesis, those requiring the inhibition of synovial cell proliferation, those requiring the induction of heat shock protein production or those requiring the inhibition of α-glycosidase, which contain as the active ingredient compounds selected from among compounds represented by general formula (I), (wherein X and Y are each H or CH 2 OH, provided that when X is CH 2 OH, Y is H, while when X is H, Y is CH 2 OH), those represented by general formula (II), (wherein R is a residue obtained by freeing a compound having an SH group from the SH group) and salts of both; and foods, drinks, cosmetics and so on, containing compounds selected from among compounds of general formula (I), those of general formula (II) and salts of both.

摘要翻译： 需要凋亡诱导的疾病的治疗或预防剂，癌性疾病，需要抑制活性氧产生的疾病，需要抑制一氧化氮产生的那些，需要抑制前列腺素合成的那些，需要抑制滑膜细胞增殖的那些 ，需要诱导热休克蛋白产生的那些或需要抑制α-糖苷酶的那些，其含有选自通式（I）表示的化合物中的活性成分的化合物（其中X和Y各自为H或CH 2 OH， 条件是当X是CH 2 OH时，Y是H，当X是H时，Y是CH 2 OH），由通式（II）表示的那些，其中R是从SH基团中释放具有SH基团的化合物获得的残基 ）和两者的盐; 和食品，饮料，化妆品等，含有选自通式（I）的化合物，通式（II）的化合物和二者的盐的化合物。

公开(公告)号：EP1106624A1

公开(公告)日：2001-06-13

申请号：EP99937011.7

申请日：1999-08-10

申请人： Takara Shuzo Co, Ltd.

发明人： KOBAYASHI, Eiji ,  OHNOGI, Hiromu ,  KOYAMA, Nobuto ,  IKAI, Katsushige ,  SAGAWA, Hiroaki ,  KATO, Ikunoshin

IPC分类号： C07K5/027 ,  C07K1/02 ,  C07C323/60 ,  C07C319/18 ,  A61K31/195

CPC分类号： C07K5/0215 ,  A61K38/00

摘要： 5-Membered ring compounds represented by general formula (I), optically active isomers thereof or salts of the same. These compounds have physiological activities including a carcinostatic effect. In said formula the bond shown by the dotted line in the 5-membered ring represents that this 5-membered ring may be either a cyclopentene ring having a double bond or a saturated cyclopentane ring, and when the 5-membered ring is a cyclopentene ring, X is OR 1 , Y is =O and Z is H, and when it is a cyclopentane ring, X is =O, Y is OR 2 and Z is OR 3 , (wherein R 1 is R 4 or -(CO)-R 5 ; R 2 is H, -R 6 or -(CO)-R 7 ; and R 3 is H, R 8 or (CO)-R 9 (wherein R 4 , R 5 , R 6 , R 7 , R 8 and R 9 are the same or different and each represents an aliphatic, aromatic or aliphatic aromatic group, and R 5 , R 7 and R 9 may be each H), provided that the case where R 2 =R 3 =H is excluded); and W represents a residue obtained by eliminating SH from an SH-containing compound.

摘要翻译： 由通式（I）表示的5元环化合物，其光学活性异构体或其盐。 这些化合物具有包括制癌作用在内的生理活性。 在所述式中，五元环中由虚线表示的键表示该5元环可以是具有双键的环戊烯环或饱和的环戊烷环，并且当5元环是环戊烯环时 X是OR1，Y是= O且Z是H，并且当它是环戊烷环时，X是= O，Y是OR2并且Z是OR3，（其中R1是R4或 - （CO）-R5; R2是 （CO）-R7;和R3是H，R8或（CO）-R9（其中R4，R5，R6，R7，R8和R9相同或不同并且各自代表脂族，芳族或 脂族芳族基团，并且R5，R7和R9可以各自为H），条件是排除R2 = R3 = H的情况）。 W表示从含SH化合物中除去SH得到的残基。

公开(公告)号：EP1038879A1

公开(公告)日：2000-09-27

申请号：EP98953005.0

申请日：1998-11-11

申请人： Takara Shuzo Co, Ltd.

发明人： ENOKI, Tatsuji A-204, T.O Kopo Ishiyama ,  SAGAWA, Hiroaki 503, Hamoparesu Kusatsu ,  TOMINAGA, Takanari ,  NISHIYAMA, Eiji ,  KOYAMA, Nobuto ,  SAKAI, Takeshi 230, Raionzumanshon Shinagawamachi ,  YU, Fu-Gong ,  IKAI, Katsushige ,  KATO, Ikunoshin

IPC分类号： C07H3/10 ,  C07H11/00 ,  C08B37/00 ,  C08B37/12 ,  A61K31/70 ,  A61K31/725 ,  A01N1/00 ,  A01N3/00 ,  A23L1/30 ,  A23L3/3562 ,  A23L3/3544 ,  C09K15/06

CPC分类号： A01N43/04 ,  A23L3/3472 ,  A23L3/3544 ,  A23L3/3562 ,  A23L33/105 ,  A61K31/341 ,  A61K31/7048

摘要： Medicinal compositions for treating, ameliorating or preventing diseases with sensitivity to 3,6-anhydrogalactopyranose represented by formula (1):
foods, drinks, cosmetics, etc. containing as the active ingredient at least one member selected from the group consisting of the above-mentioned compound, its aldehyde, its hydrate and 2-O-methylated derivatives thereof and soluble sugar compounds containing the above compound. This compound also shows, for example, an apoptosis-inducing activity, a carcinostatic activity and inhibitory activities on the production of active oxygen, lipid peroxide radicals and NO, which makes it useful also as the active ingredient of antioxidants and preservatives.

摘要翻译： 由下式表示用于治疗，预防或改善与疾病的敏感性至3,6- anhydrogalactopyranose药用组合物（1）：食品，饮料，化妆品等。含有作为活性成分的至少一种选自下列一组中选择的 上述化合物，其醛，其水合物及它们的2-O-甲基化衍生物以及含有上述化合物的可溶性糖化合物。 因此，该化合物显示出，例如，对细胞凋亡诱导活性，制癌活性和对生产活性氧，过氧化脂质自由基的抑制活性和NO，这使得它非常有用，从而抗氧化剂和防腐剂的活性成分。