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    METHOD FOR GENE INTRODUCTION INTO TARGET CELLS BY RETROVIRUS
    1.
    发明公开
    METHOD FOR GENE INTRODUCTION INTO TARGET CELLS BY RETROVIRUS 失效
    ZEELZELLEN MIT HILFE VON RETROVIREN VERFAHREN ZUREINFÜHRUNGVON GENEN

    公开(公告)号：EP0870839A1

    公开(公告)日：1998-10-14

    申请号：EP96937515.3

    申请日：1996-11-07

    申请人： TAKARA SHUZO CO. LTD.

    发明人： ASADA, Kiyozo ,  UEMORI, Takashi ,  UENO, Takashi ,  KOYAMA, Nobuto ,  HASHINO, Kimikazu ,  KATO, Ikunoshiu

    IPC分类号： C12N15/86 ,  C12N15/12 ,  C12N5/10

    CPC分类号： C12N15/86 ,  A61K48/00 ,  C07K14/505 ,  C07K14/78 ,  C07K2319/00 ,  C12N9/1088 ,  C12N2740/13043 ,  C12N2740/13045

    摘要： A method for increasing the efficiency of gene transfer into target cells with a retrovirus is disclosed. In the method, the target cells are infected with the retrovirus in the presence of either a mixture of an effective amount of a functional material having retrovirus binding domain and an effective amount of another functional material having target cell binding domain, or an effective amount of a functional material having these binding domains on the same molecule. The functional materials may be used without immobilization or with immobilized on beads. The method is useful, for example, gene therapy.

    摘要翻译： 公开了一种提高逆转录病毒基因转移到靶细胞中的效率的方法。 在该方法中，目标细胞在有效量的具有逆转录病毒结合结构域的功能材料和有效量的具有靶细胞结合结构域的功能材料的混合物或有效量的 在同一分子上具有这些结合结构域的功能材料。 功能材料可以不固定地使用或固定在珠上。 该方法是有用的，例如基因治疗。

    5-MEMBERED RING COMPOUNDS
    2.
    发明公开
    5-MEMBERED RING COMPOUNDS 有权
    五成分环化合物

    公开(公告)号：EP1106624A1

    公开(公告)日：2001-06-13

    申请号：EP99937011.7

    申请日：1999-08-10

    申请人： Takara Shuzo Co, Ltd.

    发明人： KOBAYASHI, Eiji ,  OHNOGI, Hiromu ,  KOYAMA, Nobuto ,  IKAI, Katsushige ,  SAGAWA, Hiroaki ,  KATO, Ikunoshin

    IPC分类号： C07K5/027 ,  C07K1/02 ,  C07C323/60 ,  C07C319/18 ,  A61K31/195

    CPC分类号： C07K5/0215 ,  A61K38/00

    摘要： 5-Membered ring compounds represented by general formula (I), optically active isomers thereof or salts of the same. These compounds have physiological activities including a carcinostatic effect. In said formula the bond shown by the dotted line in the 5-membered ring represents that this 5-membered ring may be either a cyclopentene ring having a double bond or a saturated cyclopentane ring, and when the 5-membered ring is a cyclopentene ring, X is OR 1 , Y is =O and Z is H, and when it is a cyclopentane ring, X is =O, Y is OR 2 and Z is OR 3 , (wherein R 1 is R 4 or -(CO)-R 5 ; R 2 is H, -R 6 or -(CO)-R 7 ; and R 3 is H, R 8 or (CO)-R 9 (wherein R 4 , R 5 , R 6 , R 7 , R 8 and R 9 are the same or different and each represents an aliphatic, aromatic or aliphatic aromatic group, and R 5 , R 7 and R 9 may be each H), provided that the case where R 2 =R 3 =H is excluded); and W represents a residue obtained by eliminating SH from an SH-containing compound.

    摘要翻译： 由通式（I）表示的5元环化合物，其光学活性异构体或其盐。 这些化合物具有包括制癌作用在内的生理活性。 在所述式中，五元环中由虚线表示的键表示该5元环可以是具有双键的环戊烯环或饱和的环戊烷环，并且当5元环是环戊烯环时 X是OR1，Y是= O且Z是H，并且当它是环戊烷环时，X是= O，Y是OR2并且Z是OR3，（其中R1是R4或 - （CO）-R5; R2是 （CO）-R7;和R3是H，R8或（CO）-R9（其中R4，R5，R6，R7，R8和R9相同或不同并且各自代表脂族，芳族或 脂族芳族基团，并且R5，R7和R9可以各自为H），条件是排除R2 = R3 = H的情况）。 W表示从含SH化合物中除去SH得到的残基。

    THERAPEUTIC AGENTS
    3.
    发明公开
    THERAPEUTIC AGENTS 有权
    抗细胞凋亡Wirkstoffe

    公开(公告)号：EP1086952A1

    公开(公告)日：2001-03-28

    申请号：EP99923961.9

    申请日：1999-06-08

    申请人： Takara Shuzo Co, Ltd.

    发明人： ENOKI, Tatsuji ,  TOMONO, Jun ,  KOYAMA, Nobuto ,  IKAI, Katsushige ,  SAGAWA, Hiroaki ,  KATO, Ikunoshin

    IPC分类号： C07D493/08 ,  C07D309/32 ,  A61K31/35 ,  A61K7/00 ,  A23L1/30 ,  A23L2/00

    CPC分类号： A61K31/7004 ,  A23L3/3535 ,  A23L3/3562 ,  A23L33/10 ,  A23V2002/00 ,  A61K31/35 ,  A61K31/351 ,  A61K31/357 ,  A23V2250/60 ,  A23V2250/608 ,  A23V2250/5024 ,  A23V2250/5036

    摘要： Therapeutic or preventive agents for diseases requiring apoptosis induction, cancerous diseases, diseases requiring the inhibition of active oxygen production, those requiring the inhibition of nitrogen monoxide production, those requiring the inhibition of prostaglandin synthesis, those requiring the inhibition of synovial cell proliferation, those requiring the induction of heat shock protein production or those requiring the inhibition of α-glycosidase, which contain as the active ingredient compounds selected from among compounds represented by general formula (I), (wherein X and Y are each H or CH 2 OH, provided that when X is CH 2 OH, Y is H, while when X is H, Y is CH 2 OH), those represented by general formula (II), (wherein R is a residue obtained by freeing a compound having an SH group from the SH group) and salts of both; and foods, drinks, cosmetics and so on, containing compounds selected from among compounds of general formula (I), those of general formula (II) and salts of both.

    摘要翻译： 需要凋亡诱导的疾病的治疗或预防剂，癌性疾病，需要抑制活性氧产生的疾病，需要抑制一氧化氮产生的那些，需要抑制前列腺素合成的那些，需要抑制滑膜细胞增殖的那些 ，需要诱导热休克蛋白产生的那些或需要抑制α-糖苷酶的那些，其含有选自通式（I）表示的化合物中的活性成分的化合物（其中X和Y各自为H或CH 2 OH， 条件是当X是CH 2 OH时，Y是H，当X是H时，Y是CH 2 OH），由通式（II）表示的那些，其中R是从SH基团中释放具有SH基团的化合物获得的残基 ）和两者的盐; 和食品，饮料，化妆品等，含有选自通式（I）的化合物，通式（II）的化合物和二者的盐的化合物。

    REMEDIES OR PREVENTIVES CONTAINING CYCLOPENTENONE COMPOUNDS AS THE ACTIVE INGREDIENT
    5.
    发明公开
    REMEDIES OR PREVENTIVES CONTAINING CYCLOPENTENONE COMPOUNDS AS THE ACTIVE INGREDIENT 有权
    HEILMITTEL UND VORBEUGENDE MITTEL DIE CYCLOPENTENONVERBINDUNGEN ALS WIRKSAMEN STOFF ENTHALTEN

    公开(公告)号：EP1112742A1

    公开(公告)日：2001-07-04

    申请号：EP99937010.9

    申请日：1999-08-10

    申请人： Takara Shuzo Co, Ltd.

    发明人： KOBAYASHI, Eiji ,  OHNOGI, Hiromu, A-406, Takarashuzoshataku ,  SAGAWA, Hiroaki, 503, Hamoparesu-Kusatsu ,  TOMINAGA, Takanari ,  NISHIYAMA, Eiji ,  KOYAMA, Nobuto ,  IKAI, Katsushige ,  KATO, Ikunoshin

    IPC分类号： A61K31/215 ,  A61K31/22

    CPC分类号： A61K31/215 ,  A61K31/22 ,  C07C69/013 ,  C07C2601/10 ,  Y02A50/411

    摘要： Remedies or preventives for diseases with a need for immunoregulation, diseases with a need for inhibition of inflammation, diseases with a need for regulation of tumor necrosis factor production, diseases with a need for regulation of fungal growth, diseases with a need for regulation of cell adhesion or disease with a deed for induction of heat-shock protein, which contain as the active ingredient at least one compound selected from among cyclopentenone derivatives represented by general formula [I], optically active isomers and salts thereof, wherein R 1 and R 2 are the same or different and each represents hydrogen, an aliphatic group, an aromatic group or an aromatic aliphatic group.

    摘要翻译： 需要免疫调节的疾病的治疗或预防措施，需要抑制炎症的疾病，需要调节肿瘤坏死因子产生的疾病，需要调节真菌生长的疾病，需要的疾病 含有诱导热休克蛋白的细胞的细胞粘附或疾病的调节，其含有作为活性成分的至少一种选自通式Ⅳ所示的环戊烯酮衍生物的化合物，其旋光异构体及其盐，其中R 1和R 2为 相同或不同，各自表示氢，脂族基，芳基或芳族脂族基。